19 research outputs found
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID
Total Synthesis of Clavosolide A via Asymmetric AlcoholâMediated Carbonyl Allylation: Beyond Protecting Groups or Chiral Auxiliaries in Polyketide Construction
Total Synthesis of Clavosolide A via Asymmetric AlcoholâMediated Carbonyl Allylation: Beyond Protecting Groups or Chiral Auxiliaries in Polyketide Construction
Photorefractive gratings in the organic crystal 2-cyclooctylamino-5-nitropyridine doped with 7,7,8,8-tetracyanoquinodimethane
Spectral holeburning properties ofR? color centers in LiF: dependence on doping and irradiation processes
Analysis of the recording efficiency of dynamic gratings in bacteriorhodopsin with the help of differential absorption spectra
The PalladiumâCatalyzed Carboxytelomerization of Butadiene with Agrobased Alcohols and Polyols
International audienceThe palladium catalyzed carboxytelomerization reaction of alcohols with butadiene allows for efficient and atom-economical access to unsaturated alkyl nona-3,8-dienoate esters. The study focused on the nature of the catalyst (phosphine and acid) with ethanol. Commercially available triarylphosphines and carboxylic acids associated with a simple palladium precursor appear to be the best combination for inâ
situ generation of the catalyst. The reaction conditions were further optimized and the carboxytelomerization reaction was efficiently applied to the full transformation of several industrially relevant agro-based monoalcohols and polyols