128 research outputs found
Effect of quantum entanglement on Aharonov-Bohm oscillations, spin-polarized transport and current magnification effect
We present a simple model of transmission across a metallic mesoscopic ring.
In one of its arm an electron interacts with a single magnetic impurity via an
exchange coupling. We show that entanglement between electron and spin impurity
states leads to reduction of Aharonov-Bohm oscillations in the transmission
coefficient. The spin-conductance is asymmetric in the flux reversal as opposed
to the two probe electrical conductance which is symmetric. In the same model
in contradiction to the naive expectation of a current magnification effect, we
observe enhancement as well as the suppression of this effect depending on the
system parameters. The limitations of this model to the general notion of
dephasing or decoherence in quantum systems are pointed out.Comment: Talk presented at the International Discussion Meeting on Mesoscopic
and Disordered systems, December, 2000, at IISc Bangalore 17 pages, 8figure
Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds
As the development of new classes of antibiotics slows, bacterial resistance to existing antibiotics is becoming an increasing problem. A potential solution is to develop treatment strategies with an alternative mode of action. We consider one such strategy: anti-adhesion therapy. Whereas antibiotics act directly upon bacteria, either killing them or inhibiting their growth, anti-adhesion therapy impedes the binding of bacteria to host cells. This prevents bacteria from deploying their arsenal of virulence mechanisms, while simultaneously rendering them more susceptible to natural and artificial clearance. In this paper, we consider a particular form of anti-adhesion therapy, involving biomimetic multivalent adhesion molecule 7 coupled polystyrene microbeads, which competitively inhibit the binding of bacteria to host cells. We develop a mathematical model, formulated as a system of ordinary differential equations, to describe inhibitor treatment of a Pseudomonas aeruginosa burn wound infection in the rat. Benchmarking our model against in vivo data from an ongoing experimental programme, we use the model to explain bacteria population dynamics and to predict the efficacy of a range of treatment strategies, with the aim of improving treatment outcome. The model consists of two physical compartments: the host cells and the exudate. It is found that, when effective in reducing the bacterial burden, inhibitor treatment operates both by preventing bacteria from binding to the host cells and by reducing the flux of daughter cells from the host cells into the exudate. Our model predicts that inhibitor treatment cannot eliminate the bacterial burden when used in isolation; however, when combined with regular or continuous debridement of the exudate, elimination is theoretically possible. Lastly, we present ways to improve therapeutic efficacy, as predicted by our mathematical model
Natural gaits of the non-pathological flat foot and high-arched foot
There has been a controversy as to whether or not the non-pathological flat
foot and high-arched foot have an effect on human walking activities. The 3D
foot scanning system was employed to obtain static footprints from subjects
adopting a half-weight-bearing stance. Based upon their footprints, the
subjects were divided into two groups: the flat-footed and the high-arched. The
plantar pressure measurement system was used to measure and record the
subjects' successive natural gaits. Two indices were proposed: distribution of
vertical ground reaction force (VGRF) of plantar and the rate of the footprint
areas. Using these two indices to compare the natural gaits of the two subject
groups, we found that (1) in stance phase, there is a significant difference
(p<0.01) in the distributions of VGRF of plantar; (2) in a stride cycle, there
is also a significant difference (p<0.01) in the rates of the footprint areas.
Our analysis suggests that when walking, the VGRF of the plantar brings greater
muscle tension to the flat-footed while a smaller rate of the footprint areas
brings greater stability to the high-arched.Comment: 8 pages, 4 figure
A Microscope Automated Fluidic System to Study Bacterial Processes in Real Time
Most time lapse microscopy experiments studying bacterial processes ie growth, progression through the cell cycle and motility have been performed on thin nutrient agar pads. An important limitation of this approach is that dynamic perturbations of the experimental conditions cannot be easily performed. In eukaryotic cell biology, fluidic approaches have been largely used to study the impact of rapid environmental perturbations on live cells and in real time. However, all these approaches are not easily applicable to bacterial cells because the substrata are in all cases specific and also because microfluidics nanotechnology requires a complex lithography for the study of micrometer sized bacterial cells. In fact, in many cases agar is the experimental solid substratum on which bacteria can move or even grow. For these reasons, we designed a novel hybrid micro fluidic device that combines a thin agar pad and a custom flow chamber. By studying several examples, we show that this system allows real time analysis of a broad array of biological processes such as growth, development and motility. Thus, the flow chamber system will be an essential tool to study any process that take place on an agar surface at the single cell level
Interactive impact of ethnic distance and cultural familiarity on the perceived effects of free trade agreements
Past research on free trade agreements (FTAs) mostly uses an economic perspective to assess their impact on the level of trade and investments between nations. As a result, there is a distinct paucity of research on the perceptions of employees and managers in organizations affected by FTAs, towards the likely outcomes of those FTAs. We address this gap by using the context of recently signed China-Australia free trade agreement (ChAFTA) to develop a multidimensional scale for the perceived advantages and disadvantages of FTAs. Drawing on social identity theory and the similarly-attraction paradigm we also show direct and interactive effects of perceived ethnic distance (between home and partner country) and cultural familiarity (with the FTA partner country) on these perceived outcomes of FTAs. Our findings highlight the need to look beyond the economic perspective and consider a much broader range of perceived outcomes of FTAs
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