Topography-mediated Control of Cellular Response: Migration, Intracellular Crowding, and Gene-delivery

Overall, the work presented in this thesis is to explore topography-mediated alterations of cell behaviors and investigate cell-material interface-induced subcellular behaviors like cell morphology alteration, cell migration in wound healing, intracellular macromolecular crowding, and topography-modulated gene delivery of stem cells. The work demonstrates that the topography plays an important role in modulating cell behaviors, which provides useful information to better understanding material-cells interfaces and many new insights may be elucidated for tissue engineering and regenerative medicine approaches

Recovering stellar population parameters via different population models and stellar libraries

Three basic ingredients are required to generate a simple stellar population (SSP) library, i.e., an initial mass function (IMF), a stellar evolution model/isochrones, and an empirical/theoretical stellar spectral library. However, there are still some uncertainties to the determination and understanding of these ingredients. We perform the spectral fitting to test the relative parameter offsets between these uncertainties using two different stellar population models, two different empirical stellar libraries, two different isochrones, and the Salpeter and Chabrier IMFs. Based on these setups, we select five SSP libraries generated with the Galaxev/STELIB and Vazdekis/MILES models, and apply them to the pPXF full-spectrum fitting of both MaNGA and mock spectra. We find that: 1) Compared to the Galaxev/STELIB model, spectral fitting qualities with the Vazdekis/MILES model have significant improvements for those metal-rich (especially over-solar) spectra, which cause better reduced $\chi^2$ distributions and more precisely fitted absorption lines. This might due to the lack of metal rich stars in the empirical STELIB library, or code improvement of the Vazdekis model. 2) When applying the Vazdekis/MILES model for spectral fitting, the IMF variation will lead to not only a systematic offset in $M_*/L_r$, but also offsets in age and metallicity, and these offsets increase with increasing stellar population ages. However, the IMF-variation caused metallicity offsets disappear in the case of Galaxev/STELIB based libraries. 3) The Padova2000 model provides a better match to the MaNGA galaxy spectra at [M/H]$_L<-1.0$, while the BaSTI model match the local galaxy spectra better at [M/H]$_L>-1.0$. Current tests suggest that spectral fitting with the Vazdekis/MILES+BaSTI combination would be a better choice for local galaxies.Comment: 19 pages, 17 figures, accepted for publication in MNRA

Convolutional Neural Networks over Tree Structures for Programming Language Processing

Programming language processing (similar to natural language processing) is a hot research topic in the field of software engineering; it has also aroused growing interest in the artificial intelligence community. However, different from a natural language sentence, a program contains rich, explicit, and complicated structural information. Hence, traditional NLP models may be inappropriate for programs. In this paper, we propose a novel tree-based convolutional neural network (TBCNN) for programming language processing, in which a convolution kernel is designed over programs' abstract syntax trees to capture structural information. TBCNN is a generic architecture for programming language processing; our experiments show its effectiveness in two different program analysis tasks: classifying programs according to functionality, and detecting code snippets of certain patterns. TBCNN outperforms baseline methods, including several neural models for NLP.Comment: Accepted at AAAI-1