Who is in the transition gap? Transition from CAMHS to AMHS in the Republic of Ireland

Objective: The ITRACK study explored the process and predictors of transition between Child and Adolescent Mental Health Services (CAMHS) and Adult Mental Health Services (AMHS) in the Republic of Ireland. Method: Following ethical approval, clinicians in each of Ireland's four Health Service Executive (HSE) areas were contacted, informed about the study and invited to participate. Clinicians identified all cases who had reached the transition boundary (i.e. upper age limit for that CAMHS team ) between January and December 2010. Data were collected on clinical and socio-demographic details and factors that informed the decision to refer or not refer to AMHS and case notes were scrutinised to ascertain the extent of information exchanged between services during transition

Chiral Fluid Dynamics and Collapse of Vacuum Bubbles

We study the expansion dynamics of a quark-antiquark plasma droplet from an initial state with restored chiral symmetry. The calculations are made within the linear $\sigma$ model scaled with an additional scalar field representing the gluon condensate. We solve numerically the classical equations of motion for the meson fields coupled to the fluid-dynamical equations for the plasma. Strong space-time oscillations of the meson fields are observed in the course of the chiral transition. A new phenomenon, the formation and collapse of vacuum bubbles, is also predicted. The particle production due to the bremsstrahlung of the meson fields is estimated.Comment: 12 pages Revtex,5 figures, Figures modified, minor changes in text. To be published in Phys. Rev. Let

On multiplicity correlations in the STAR data

The STAR data on the multiplicity correlations between narrow psudorapidity bins in the pp and AuAu collisions are discussed. The PYTHIA 8.145 generator is used for the pp data, and a naive superposition model is presented for the AuAu data. It is shown that the PYTHIA generator with default parameter values describes the pp data reasonably well, whereas the superposition model fails to reproduce the centrality dependence seen in the data. Some possible reasons for this failure and a comparison with other models are presented.Comment: 8 pages, 3 figure

Phase structure of lattice QCD at finite temperature for 2+1 flavors of Kogut-Susskind quarks

We report on a study of the finite-temperature chiral transition on an $N_t=4$ lattice for 2+1 flavors of Kogut-Susskind quarks. We find the point of physical quark masses to lie in the region of crossover, in agreement with results of previous studies. Results of a detailed examination of the $m_{u,d}=m_s$ case indicate vanishing of the screening mass of $\sigma$ meson at the end point of the first-order transition.Comment: LATTICE98(hightemp), 3 pages, 4 figure

Is Anomalous Production of Omega and anti-Omega Evidence for Disoriented Chiral Condensates?

No conventional picture of nucleus-nucleus collisions has yet been able to explain the abundance of Omega and anti-Omega hyperons in central collisions between Pb nuclei at 158 A GeV at the CERN SPS. We argue that this is evidence that they are produced as topological defects arising from the formation of disoriented chiral condensates (DCC) with an average domain size of about 2 fm.Comment: version 2 containing formulas, accepted by PR

Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification

BACKGROUND: Translating genomic technologies into healthcare applications for the malaria parasite Plasmodium falciparum has been limited by the technical and logistical difficulties of obtaining high quality clinical samples from the field. Sampling by dried blood spot (DBS) finger-pricks can be performed safely and efficiently with minimal resource and storage requirements compared with venous blood (VB). Here, the use of selective whole genome amplification (sWGA) to sequence the P. falciparum genome from clinical DBS samples was evaluated, and the results compared with current methods that use leucodepleted VB. METHODS: Parasite DNA with high (>95%) human DNA contamination was selectively amplified by Phi29 polymerase using short oligonucleotide probes of 8-12 mers as primers. These primers were selected on the basis of their differential frequency of binding the desired (P. falciparum DNA) and contaminating (human) genomes. RESULTS: Using sWGA method, clinical samples from 156 malaria patients, including 120 paired samples for head-to-head comparison of DBS and leucodepleted VB were sequenced. Greater than 18-fold enrichment of P. falciparum DNA was achieved from DBS extracts. The parasitaemia threshold to achieve >5× coverage for 50% of the genome was 0.03% (40 parasites per 200 white blood cells). Over 99% SNP concordance between VB and DBS samples was achieved after excluding missing calls. CONCLUSION: The sWGA methods described here provide a reliable and scalable way of generating P. falciparum genome sequence data from DBS samples. The current data indicate that it will be possible to get good quality sequence on most if not all drug resistance loci from the majority of symptomatic malaria patients. This technique overcomes a major limiting factor in P. falciparum genome sequencing from field samples, and paves the way for large-scale epidemiological applications

The Use of HCG‐Based Combination Therapy for Recovery of Spermatogenesis after Testosterone Use

Introduction and AimAbout 3 million men take testosterone in the United States with many reproductive‐age men unaware of the negative impact of testosterone supplementation on fertility. Addressing this population, we provide an early report on the use of human chorionic gonadotropin (HCG)‐based combination therapy in the treatment of a series of men with likely testosterone‐related azoospermia or severe oligospermia. MethodsWe retrospectively reviewed charts from two tertiary care infertility clinics to identify men presenting with azoospermia or severe oligospermia (<1 million sperm/mL) while taking exogenous testosterone. All were noted to have been placed on combination therapy, which included 3,000 units HCG subcutaneously every other day supplemented with clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle‐stimulating hormone (or combination) according to physician preference.Main Outcome MeasureClinical outcomes, including hormone values, semen analyses, and clinical pregnancies, were tracked. ResultsForty‐nine men were included in this case series. Return of spermatogenesis for azoospermic men or improved counts for men with severe oligospermia was documented in 47 men (95.9%), with one additional man (2.1%) having a documented pregnancy without follow‐up semen analysis. The average time to return of spermatogenesis was 4.6 months with a mean first density of 22.6 million/mL. There was no significant difference in recovery by type of testosterone administered or supplemental therapy. No men stopped HCG or supplemental medications because of adverse events. ConclusionsWe here provide an early report of the feasibility of using combination therapy with HCG and supplemental medications in treating men with testosterone‐related infertility. Future discussion and studies are needed to further characterize this therapeutic approach and document the presumed improved tolerability and speed of recovery compared with unaided withdrawal of exogenous testosterone. Wenker EP, Dupree JM, Langille GM, Kovac J, Ramasamy R, Lamb D, Mills JN, and Lipshultz LI. The use of HCG‐based combination therapy for recovery of spermatogenesis after testosterone use. J Sex Med 2015;12:1334–1337.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111925/1/jsm12890.pd

Possible Evidence of Disoriented Chiral Condensates from the Anomaly in Omega and AntiOmega Abundances at the SPS

No conventional picture of nucleus-nucleus collisions has yet been able to explain the abundance of Omega and AntiOmega in central collisions between Pb nuclei at 158 A GeV at the CERN SPS. We argue that such a deviation from predictions of statistical thermal models and numerical simulations is evidence that they are produced as topological defects in the form of skyrmions arising from the formation of disoriented chiral condensates. The estimated domain size falls in the right range to be consistent with the so far non-observation of DCC from the distribution of neutral pions.Comment: paper presented at the ICPAQGP-2001, Jaipur, Indi

Enhanced Event-by-Event Fluctuations in Pion Multiplicity as a Signal of Disoriented Chiral Condensates at RHIC

The factorial moments of the pion multiplicity distributions are calculated with HIJING and UrQMD and found to be independent of the pT range included, in contrast to recent simulations with the linear sigma model which leads to large enhancements for pions with transverse kinetic energies below 200 MeV. This supports the use of the ratio of the factorial moments of low and high pT pions as a signal of ``new'' physics at low momentum scales, such as the formation of disoriented chiral condensates.Comment: 4 pages total, incl 4 eps figures ([email protected]

Quantum Logic for Trapped Atoms via Molecular Hyperfine Interactions

We study the deterministic entanglement of a pair of neutral atoms trapped in an optical lattice by coupling to excited-state molecular hyperfine potentials. Information can be encoded in the ground-state hyperfine levels and processed by bringing atoms together pair-wise to perform quantum logical operations through induced electric dipole-dipole interactions. The possibility of executing both diagonal and exchange type entangling gates is demonstrated for two three-level atoms and a figure of merit is derived for the fidelity of entanglement. The fidelity for executing a CPHASE gate is calculated for two 87Rb atoms, including hyperfine structure and finite atomic localization. The main source of decoherence is spontaneous emission, which can be minimized for interaction times fast compared to the scattering rate and for sufficiently separated atomic wavepackets. Additionally, coherent couplings to states outside the logical basis can be constrained by the state dependent trapping potential.Comment: Submitted to Physical Review