10 research outputs found
Visual compatibility of defibrotide with selected drugs during simulated Y-site administration
International audienc
Visual compatibility of defibrotide with selected drugs during simulated Y-site administration
Pertinence of Off-label Prescriptions of Innovating and Expensive Drugs in a University Hospital
International audienceObjectives. Pertinence of off-label prescriptions of innovative and expensive drugs needs a strict scientific appraisal to prevent adverse reaction risks and financial drift. Methods. Pertinence of such prescriptions has been analyzed in a University Hospital by bibliometric methods. Scientific publications issued from this clinical activity have been also evaluated. Results. Oncology differed from other clinical specialties by a better pertinence in justifying off-label prescriptions (good evidence level in 46% vs. 21%, scientific publications issued from A/B ranked journals: 51% versus 41%). Quality of scientific production from oncologists was also better (publication impact factor [IF] mean: 4.571 versus 2.245). Conclusions. The better pertinence of off-label prescriptions by oncologists in comparison to others clinicians' ones was mainly due to a shorter field of indications but also to a more efficient organisation such as systematic prescription by seniors, dedicated computerized provider order entry, multidisciplinary team meetings and collaborative culture
Keeping sterile water for injection cold enough for reconstitution of azacitidine in isolators
Keeping sterile 0.9% sodium chloride, 5% dextrose, and lactated Ringer’s solutions for injection cold enough for dilution of decitabine in isolators
Stability of a highly concentrated solution of epirubicin for conventional transcatheter arterial chemoembolization
International audienc