A Star in the Brainstem Reveals the First Step of Cortical Magnification

A fundamental question in the neurosciences is how central nervous system (CNS) space is allocated to different sensory inputs. Yet it is difficult to measure innervation density and corresponding representational areas in the CNS of most species. These measurements can be made in star-nosed moles (Condylura cristata) because the cortical representation of nasal rays is visible in flattened sections and afferents from each ray can be counted. Here we used electrophysiological recordings combined with sections of the brainstem to identify a large, visible star representation in the principal sensory nucleus (PrV). PrV was greatly expanded and bulged out of the brainstem rostrally to partially invade the trigeminal nerve. The star representation was a distinct PrV subnucleus containing 11 modules, each representing one of the nasal rays. The 11 PrV ray representations were reconstructed to obtain volumes and the largest module corresponded to ray 11, the mole's tactile fovea. These measures were compared to fiber counts and primary cortical areas from a previous investigation. PrV ray volumes were closely correlated with the number of afferents from each ray, but afferents from the behaviorally most important, 11th ray were preferentially over-represented. This over-representation at the brainstem level was much less than at the cortical level. Our results indicate that PrV provides the first step in magnifying CNS representations of important afferents, but additional magnification occurs at higher levels. The early development of the 11th, foveal appendage could provide a mechanism for the most important afferents to capture the most CNS space

La résilience des personnes âgées à la suite de leur exposition à un sinistre

Ce texte présente les résultats d’une étude longitudinale, menée auprès d’aînés exposés aux inondations de Juillet 1996 au Saguenay-Lac-Saint-Jean (Québec), visant à documenter leur processus de résilience. En dépit de la présence d’effets négatifs à long terme sur la santé psychologique des sinistrés (124 aînés exposés versus 107 non exposés), ainsi que des différences significatives entre sinistrés et non-sinistrés huit ans après les inondations, des retombées positives en ce qui a trait à certaines valeurs ou attitudes personnelles ont pu être observées (confiance ou optimisme envers l’avenir, sentiment de sécurité accru, croissance personnelle, spiritualité, remise en question de valeurs personnelles, ouverture à accepter de l’aide des autres

Characteristics of dust event in East Asia : Focus on the Gobi Desert, and Mongolia regions

[ABSTRACT] This study investigated the effect of snow and vegetation covers on dust emission by the correlation analysis of strong wind frequency and dust emission frequency, where the strong wind is defined with a constant threshold 6.5 m/sec. This correlation should be high (low) where the variance of land surface environment is low (large). In addition to this idea, referring to the parameterizations of threshold wind speed by NDVI and snow cover fraction, we built four hypotheses as shown in section 3.1. However, our obtained results disagreed with these in many points, and this indicates problems in the current parameterizations. We will discuss the reasons of these disagreements and some methods will be proposed to clarify these problems

A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia–like syndrome in BXH-2 mice

BXH-2 mice develop a fatal myeloid leukemia by a two-step mutagenic process. First, a BXH-2–specific recessive mutation causes a myeloproliferative syndrome. Second, retroviral insertions alter oncogenes or tumor suppressors, resulting in clonal expansion of leukemic cells. We have identified a recessive locus on chromosome 8 (Myls) that is responsible for myeloproliferation in BXH-2. This Myls interval has been narrowed down to 2 Mb and found to contain several positional candidates, including the interferon consensus sequence–binding protein 1 gene (Icsbp, also known as interferon regulatory factor 8 [IRF8]). We show that BXH-2 mice carry a mutation (915 C to T) resulting in an arginine-to-cysteine substitution at position 294 within the predicted IRF association domain of the protein. Although expression of Icsbp1 mRNA transcripts is normal in BXH-2 splenocytes, these cells are unable to produce interleukin 12 and interferon-γ in response to activating stimuli, confirming that R294C behaves as a loss-of-function mutation. Myeloproliferation in BXH-2 mice is concomitant to increased susceptibility to Mycobacterium bovis (BCG) despite the presence of resistance alleles at the Nramp1 locus. These results suggest a two-step model for chronic myeloid leukemia in BXH-2, in which inactivation of Icsbp1 predisposes to myeloproliferation and immunodeficiency. This event is required for retroviral replication, and subsequent insertional mutagenesis that causes leukemia in BXH-2 mice