An American Ambulance Driver in France during the Great War The Lasting Memory and Relationship between Harry N. Deyo, the Men of Section 591, and French Civilians

This thesis presents the experiences of Harry N. Deyo, a graduate of the University of Michigan, who volunteered to serve in the United States Army Ambulance Service in France during the Great War. The friendship between Deyo and the drivers of Section 591 lasted throughout his lifetime. These friendships were important to his life; they were a way to share common bonds and to remember the war in the context of camaraderie and affection between themselves and the French civilians who cared for them. The role of rural French civilians and the relationships formed with the American ambulance drivers is also explored. Studies of collective memory and remembrance evidence the bond shared among these distinctive groups of people. This thesis argues that the relationships between the men of Section 591 and the French civilians they encountered were unique experiences and had lasting effects long after the end of the war

An American Ambulance Driver in France during the Great War: The Lasting Memory and Relationship between Harry N. Deyo, the Men of Section 591, and French Civilians

This thesis presents the experiences of Harry N. Deyo, a graduate of the University of Michigan, who volunteered to serve in the United States Army Ambulance Service in France during the Great War. The friendship between Deyo and the drivers of Section 591 lasted throughout his lifetime. These friendships were important to his life; they were a way to share common bonds and to remember the war in the context of camaraderie and affection between themselves and the French civilians who cared for them. The role of rural French civilians and the relationships formed with the American ambulance drivers is also explored. Studies of collective memory and remembrance evidence the bond shared among these distinctive groups of people. This thesis argues that the relationships between the men of Section 591 and the French civilians they encountered were unique experiences and had lasting effects long after the end of the war

Development of a stochastic computational fluid dynamics approach for offshore wind farms

In this paper, a method for stochastic analysis of an offshore wind farm using computational fluid dynamics (CFD) is proposed. An existing offshore wind farm is modelled using a steady-state CFD solver at several deterministic input ranges and an approximation model is trained on the CFD results. The approximation model is then used in a Monte-Carlo analysis to build joint probability distributions for values of interest within the wind farm. The results are compared with real measurements obtained from the existing wind farm to quantify the accuracy of the predictions. It is shown that this method works well for the relatively simple problem considered in this study and has potential to be used in more complex situations where an existing analytical method is either insufficient or unable to make a good prediction

Health Utility Analysis of Tepotinib in Patients with Non-small Cell Lung Cancer Harboring MET Exon 14 Skipping

OBJECTIVES: The VISION trial showed durable activity of tepotinib in MET exon 14 (METex14) skipping non-small cell lung cancer (NSCLC). We analyzed health state utilities using patient-reported outcomes from VISION. METHODS: EQ-5D-5L and European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 responses were collected at baseline, every 6-12 weeks during treatment, and at end-of-treatment and safety follow-up. EQ-5D-5L and EORTC Quality of Life Utility Measure-Core 10 Dimensions (QLU-C10D) utilities were derived using US, Canada, UK and Taiwan value sets, where available. Utilities were analyzed with linear mixed models including covariates for progression or time-to-death (TTD). RESULTS: Utilities were derived for 273/291 patients (EQ-5D-5L, 1545 observations; QLU-C10D, 1546 observations). Mean (± standard deviation) US EQ-5D-5L utilities increased after tepotinib initiation, from 0.687 ± 0.287 at baseline to 0.754 ± 0.250 before independently assessed progression, and decreased post-progression (0.704 ± 0.288). US QLU-C10D utilities showed similar trends (0.705 ± 0.215, 0.753 ± 0.195, and 0.708 ± 0.209, respectively). Progression-based models demonstrated a statistically significant impact of progression on utilities and predicted higher utilities pre- versus post-progression. TTD-based models showed statistically significant associations of TTD with utilities and predicted declining utilities as TTD decreased. Prior treatment (yes/no) did not significantly predict utilities in progression- or TTD-based models. Utilities for Canada, UK and Taiwan showed comparable trends. CONCLUSIONS: In this first analysis of health state utilities in patients with METex14 skipping NSCLC, who received tepotinib, utilities were significantly associated with progression and TTD, but not prior treatment

Low formalin concentrations induce fine-tuned responses that are sex and age-dependent: A developmental study

The formalin test is increasingly applied as a model of inflammatory pain using high formalin concentrations (5–15%). However, little is known about the effects of low formalin concentrations on related behavioural responses. To examine this, rat pups were subjected to various concentrations of formalin at four developmental stages: 7, 13, 22, and 82 days of age. At postnatal day (PND) 7, sex differences in flinching but not licking responses were observed with 0.5% formalin evoking higher flinching in males than in females. A dose response was evident in that 0.5% formalin also produced higher licking responses compared to 0.3% or 0.4% formalin. At PND 13, a concentration of 0.8% formalin evoked a biphasic response. At PND 22, a concentration of 1.1% evoked higher flinching and licking responses during the late phase (10–30 min) in both males and females. During the early phase (0–5 min), 1.1% evoked higher licking responses compared to 0.9% or 1% formalin. 1.1% formalin produced a biphasic response that was not evident with 0.9 or 1%. At PND 82, rats displayed a biphasic pattern in response to three formalin concentrations (1.25%, 1.75% and 2.25%) with the presence of an interphase for both 1.75% and 2.25% but not for 1.25%. These data suggest that low formalin concentrations induce fine-tuned responses that are not apparent with the high formalin concentration commonly used in the formalin test. These data also show that the developing nociceptive system is very sensitive to subtle changes in formalin concentrations.Ihssane Zouikr, Melissa A. Tadros, Vicki L. Clifton, Kenneth W. Beagley, Deborah M. Hodgso

Evaluation of the Bonapace Method: a specific educational intervention to reduce pain during childbirth

Julie Bonapace,1 Nils Chaillet,2 Isabelle Gaumond,3,4 &Eacute;milie Paul-Savoie,5 Serge Marchand3,41D&eacute;partement des Sciences de l&#39;&Eacute;ducation, Universit&eacute; du Qu&eacute;bec en Abitibi-T&eacute;miscamingue, Rouyn-Noranda, Qu&eacute;bec, 2Centre de Recherche de l&#39;H&ocirc;pital Sainte-Justine, Universit&eacute; de Montr&eacute;al, Montr&eacute;al, Qu&eacute;bec, 3D&eacute;partement de chirurgie, Facult&eacute; de M&eacute;decine et des Sciences de la Sant&eacute;, Universit&eacute; de Sherbrooke, Sherbrooke, Qu&eacute;bec, 4D&eacute;partement des Sciences de la Sant&eacute;, Universit&eacute; du Qu&eacute;bec en Abitibi-T&eacute;miscamingue, Rouyn-Noranda, Qu&eacute;bec, 5&Eacute;cole des sciences infirmi&egrave;res, Facult&eacute; de m&eacute;decine et des sciences de la sant&eacute;, Universit&eacute; de Sherbrooke, Sherbrooke, Qu&eacute;bec, CanadaObjective: As pain during childbirth is very intense, several educational programs exist to help women prepare for the event. This study evaluates the efficacy of a specific pain management program, the Bonapace Method (BM), to reduce the perception of pain during childbirth. The BM involves the father, or a significant partner, in the use of several pain control techniques based on three neurophysiological pain modulation models: (1) controlling the central nervous system through breathing, relaxation, and cognitive structuring; (2) using non-painful stimuli as described in the Gate Control Theory; and (3) recruiting descending inhibition by hyperstimulation of acupressure trigger points.Methods: A multicenter case control study in Quebec on pain perception during labor and delivery compared traditional childbirth training programs (TCTPs) and the BM. Visual analog scales were used to measure pain perception during labor. In all, 25 women (TCTP: n = 12; BM: n = 13) successfully reported their perceptions of pain intensity and unpleasantness every 15 minutes.Results: A positive correlation between the progression of labor and pain was found (pain intensity: P < 0.01; pain unpleasantness: P < 0.01). When compared to TCTP, the BM showed an overall significant lower pain perception for both intensity (45%; P < 0.01) and unpleasantness (46%; P < 0.01).Conclusion: These significant differences in pain perception between TCTP and the BM suggest that the emphasis on pain modulation models and techniques during labor combined with the active participation of a partner in BM are important variables to be added to the traditional childbirth training programs for childbirth pain management.Keywords: labor pain, yoga, perinatal care, DNIC, gate control theory, cognitive structuring, massage, fathe