Recognizing Degraded Handwritten Characters

In this paper, Slavonic manuscripts from the 11th century written in Glagolitic script are investigated. State-of-the-art optical character recognition methods produce poor results for degraded handwritten document images. This is largely due to a lack of suitable results from basic pre-processing steps such as binarization and image segmentation. Therefore, a new, binarization-free approach will be presented that is independent of pre-processing deficiencies. It additionally incorporates local information in order to recognize also fragmented or faded characters. The proposed algorithm consists of two steps: character classification and character localization. Firstly scale invariant feature transform features are extracted and classified using support vector machines. On this basis interest points are clustered according to their spatial information. Then, characters are localized and eventually recognized by a weighted voting scheme of pre-classified local descriptors. Preliminary results show that the proposed system can handle highly degraded manuscript images with background noise, e.g. stains, tears, and faded characters

Readability Enhancement and Palimpsest Decipherment of Historical Manuscripts

This paper presents image acquisition and readability enhancement techniques for historical manuscripts developed in the interdisciplinary project “The Enigma of the Sinaitic Glagolitic Tradition” (Sinai II Project).1 We are mainly dealing with parchment documents originating from the 10th to the 12th centuries from St. Cather- ine’s Monastery on Mount Sinai. Their contents are being analyzed, fully or partly transcribed and edited in the course of the project. For comparison also other mss. are taken into consideration. The main challenge derives from the fact that some of the manuscripts are in a bad condition due to various damages, e.g. mold, washed out or faded text, etc. or contain palimpsest (=overwritten) parts. Therefore, the manuscripts investigated are imaged with a portable multispectral imaging system. This non-invasive conservation technique has proven extremely useful for the exami- nation and reconstruction of vanished text areas and erased or washed o palimpsest texts. Compared to regular white light, the illumination with speci c wavelengths highlights particular details of the documents, i.e. the writing and writing material, ruling, and underwritten text. In order to further enhance the contrast of the de- graded writings, several Blind Source Separation techniques are applied onto the multispectral images, including Principal Component Analysis (PCA), Independent Component Analysis (ICA) and others. Furthermore, this paper reports on other latest developments in the Sinai II Project, i.e. Document Image Dewarping, Automatic Layout Analysis, the recent result of another project related to our work: the image processing tool Paleo Toolbar, and the launch of the series Glagolitica Sinaitica

PET-BIDS, an extension to the brain imaging data structure for positron emission tomography

The Brain Imaging Data Structure (BIDS) is a standard for organizing and describing neuroimaging datasets, serving not only to facilitate the process of data sharing and aggregation, but also to simplify the application and development of new methods and software for working with neuroimaging data. Here, we present an extension of BIDS to include positron emission tomography (PET) data, also known as PET-BIDS, and share several open-access datasets curated following PET-BIDS along with tools for conversion, validation and analysis of PET-BIDS datasets

PET-BIDS, an extension to the brain imaging data structure for positron emission tomography

The Brain Imaging Data Structure (BIDS) is a standard for organizing and describing neuroimaging datasets. It serves not only to facilitate the process of data sharing and aggregation, but also to simplify the application and development of new methods and software for working with neuroimaging data. Here, we present an extension of BIDS to include positron emission tomography (PET) data (PET-BIDS). We describe the PET-BIDS standard in detail and share several open-access datasets curated following PET-BIDS. Additionally, we highlight several tools which are already available for converting, validating and analyzing PET-BIDS datasets.Competing Interest StatementThe authors have declared no competing interest

The past, present, and future of the Brain Imaging Data Structure (BIDS)

The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown over time. We outline the principles behind the project, the mechanisms by which it has been extended, and some of the challenges being addressed as it evolves. We also discuss the lessons learned through the project, with the aim of enabling researchers in other domains to learn from the success of BIDS

Project: Sinaitic Glagolitic Sacramentary (Euchologium) Fragments

Project summary: Sinaitic Glagolitic Sacramentary (Euchologium) Fragment

Image Acquisition & Processing Routines for Damaged Manuscripts

This paper presents an overview of data acquisition and processing procedures of an interdisciplinary project of philologists and image processing experts aiming at the decipherment and reconstruction of damaged manuscripts. The digital raw image data was acquired via multi-spectral imaging. As a preparatory step we developed a method of foreground-background separation (binarisation) especially designed for multi-spectral images of degraded documents. On the basis of the binarised images further applications were developed: an automatic character decomposition and primitive extraction dissects the scriptural elements into analysable pieces that are necessary for palaeographic and graphemic analyses, writing tool recognition, text restoration, and optical character recognition. The results of the relevant procedures can be stored and interrogated in a database application. Furthermore, a semi-automatic page layout analysis provides codicological information on latent page contents (script, ruling, decorations)

Development of a Telemedical Network Supporting an Automated Flow Cytometric Analysis for the Clinical Follow-up of Leukaemia

In patients with acute lymphoblastic leukaemia (ALL), treatment response is increasingly evaluated with minimal residual disease (MRD) analyses. Flow Cytometry (FCM) is a fast and sensitive method to detect MRD. However, the interpretation of these multi-parametric data requires intensive operator training and experience. This paper presents a pipeline-software, as a ready-to-use FCM-based MRD-assessment tool for the daily clinical practice for patients with ALL. The new tool increases accuracy in assessment of FCM-MRD in samples which are difficult to analyse by conventional operator-based gating since computer-aided analysis potentially has a superior resolution due to utilization of the whole multi-parametric FCM-data space at once instead of step-wise, two-dimensional plot-based visualization. The system developed as a telemedical network reduces the work-load and lab-costs, staff-time needed for training, continuous quality control, operator-based data interpretation. It allows dissemination of automated FCM-MRD analysis to medical centres which have no established expertise for the benefit of an even larger community of diseased children worldwide. We established a telemedical network system for analysis and clinical follow-up and treatment monitoring of Leukaemia. The system is scalable and adapted to link several centres and laboratories worldwide