Thermodynamics of the Massive Gross-Neveu Model

We study the thermodynamics of massive Gross-Neveu models with explicitly broken discrete or continuous chiral symmetries for finite temperature and fermion densities. The large $N$ limit is discussed bearing attention to the no-go theorems for symmetry breaking in two dimensions which apply to the massless cases. The main purpose of the study is to serve as analytical orientation for the more complex problem of chiral transition in $4-$dimensional QCD with quarks. For any non-vanishing fermion mass we find, at finite densities, lines of first order phase transitions. For small mass values traces of would-be second order transitions and a tricritical point are recognizable. We study the thermodynamics of these models, and in the model with broken continuous chiral symmetry we examine the properties of the pion like state.Comment: 34 pages (+18 figures, available upon request to [email protected]), LATEX file, uses art12a.sty, macro included, UGVA-DPT 1994/06-85

On the ground state of gapless two flavor color superconductors

This paper is devoted to the study of some aspects of the instability of two flavor color superconductive quark matter. We find that, beside color condensates, the Goldstone boson related to the breaking of $U(1)_A$ suffers of a velocity instability. We relate this wrong sign problem, which implies the existence of a Goldstone current in the ground state or of gluonic condensation, to the negative squared Meissner mass of the $8^{th}$ gluon in the g2SC phase. Moreover we investigate the Meissner masses of the gluons and the squared velocity of the Goldstone in the multiple plane wave LOFF states, arguing that in such phases both the chromo-magnetic instability and the velocity instability are most probably removed. We also do not expect Higgs instability in such multiple plane wave LOFF. The true vacuum of gapless two flavor superconductors is thus expected to be a multiple plane wave LOFF state.Comment: 16 pages, RevTe3X4 styl

Superfluid and Pseudo-Goldstone Modes in Three Flavor Crystalline Color Superconductivity

We study the bosonic excitations in the favorite cubic three flavor crystalline LOFF phases of QCD. We calculate in the Ginzburg-Landau approximation the masses of the eight pseudo Nambu-Goldstone Bosons (NGB) present in the low energy theory. We also compute the decay constants of the massless NGB Goldstones associated to superfluidity as well as those of the eight pseudo NGB. Differently from the corresponding situation in the Color-Flavor-Locking phase, we find that meson condensation phases are not expected in the present scenario.Comment: 10 pages, RevTeX4 class. Section IIIA enlarged, to appear on Phys. Rev.

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype

Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL or 15 \u3bcg/0.1 mL) or PBS (0.1 mL) before (group 1 and 2) or after (group 3 and 4) the development of proteinuria ( 65100 mg/dl). Two additional mice groups were provided by including 20 MRL/lpr mice which were prophylactically injected with SERPINB3 (10 mice, group 5) or PBS (10 mice, group 6). Time of occurrence and levels of anti-dsDNA and anti-C1q antibodies, proteinuria and serum creatinine, overall- and proteinuria-free survival were assessed in mice followed up to natural death. Histological analysis was performed in kidneys of both lupus models. The Th17:Treg cell ratio was assessed by flow-cytometry in splenocytes of treated and untreated MRL/lpr mice. Statistical analysis was performed using non parametric tests and Kaplan-Meier curves, when indicated. Results: Autoantibody levels and proteinuria were significantly decreased and time of occurrence significantly delayed in SERPINB3-treated mice vs. controls. In agreement with these findings, proteinuria-free and overall survival were significantly improved in SERPINB3-treated groups vs. controls. Histological analysis demonstrated a lower prevalence of severe tubular lesions in kidneys of group 5 vs. group 6. SERPINB3-treated mice showed an overall trend toward a reduced prevalence of severe lesions in both strains. Th17:Treg ratio was significantly decreased in splenocytes of MRL/lpr mice treated with SERPINB3, compared to untreated control mice. Conclusions: SERPINB3 significantly improves disease course and delays the onset of severe glomerulonephritis in lupus-prone mice, possibly inducing a more tolerogenic immune phenotype

The Crystallography of Strange Quark Matter

Cold three-flavor quark matter at large (but not asymptotically large) densities may exist as a crystalline color superconductor. We explore this possibility by calculating the gap parameter Delta and free energy Omega(Delta) for possible crystal structures within a Ginzburg-Landau approximation, evaluating Omega(Delta) to order Delta^6. We develop a qualitative understanding of what makes a crystal structure stable, and find two structures with particularly large values of Delta and the condensation energy, within a factor of two of those for the CFL phase known to characterize QCD at asymptotically large densities. The robustness of these phases results in their being favored over wide ranges of density and though it also implies that the Ginzburg-Landau approximation is not quantitatively reliable, previous work suggests that it can be trusted for qualitative comparisons between crystal structures. We close with a look ahead at the calculations that remain to be done in order to make contact with observed pulsar glitches and neutron star cooling.Comment: 6 pages, 3 figures. Contribution to the proceedings of Strangeness in Quark Matter 2006, UCLA. Talk given by Rishi Sharm

Beads for Cell Immobilization: Comparison of Alternative Additive Manufacturing Techniques

The attachment or entrapment of microbial cells and enzymes are promising solutions for various industrial applications. When the traps are beads, they are dispersed in a fluidized bed in a vessel where a pump guarantees fresh liquid inflow and waste outflow without washing out the cells. Scientific papers report numerous types of cell entrapment, but most of their applications remain at the laboratory level. In the present research, rigid polymer beads were manufactured by two different additive manufacturing (AM) techniques in order to verify the economy, reusability, and stability of the traps, with a view toward a straightforward industrial application. The proposed solutions allowed for overcoming some of the drawbacks of traditional manufacturing solutions, such as the limited mechanical stability of gel traps, and they guaranteed the possibility of producing parts of constant quality with purposely designed exchange surfaces, which are unfeasible when using conventional processes. AM proved to be a viable manufacturing solution for beads with complex shapes of two different size ranges. A deep insight into the production and characteristics of beads manufactured by AM is provided. The paper provides biotechnologists with a manufacturing perspective, and the results can be directly applied to transit from the laboratory to the industrial scale

Conditions for transient epidemics of waterborne disease in spatially explicit systems

Waterborne diseases are a diverse family of infections transmitted through ingestion of-or contact with-water infested with pathogens. Outbreaks of waterborne infections often show well-defined spatial signatures that are typically linked to local eco-epidemiological conditions, water-mediated pathogen transport and human mobility. In this work, we apply a spatially explicit network model describing the transmission cycle of waterborne pathogens to determine invasion conditions in metacommunities endowed with a realistic spatial structure. Specifically, we aim to define conditions under which pathogens can temporarily colonize a set of human communities, thus triggering a transient epidemic outbreak. To that end, we apply generalized reactivity analysis, a recently developed methodological framework for the study of transient dynamics in ecological systems subject to external perturbations. The study of pathogen invasion is complemented by the detection of the spatial signatures associated with the perturbations to a disease-free system that are expected to be amplified the most over different time scales. Understanding the drivers of waterborne disease dynamics over time scales that are relevant to epidemic and/or endemic transmission is a crucial, cross-disciplinary challenge, as large portions of the developing world still struggle to cope with the burden of these infections