Viscous Asymptotically Flat Reissner-Nordstr\"om Black Branes

We study electrically charged asymptotically flat black brane solutions whose world-volume fields are slowly varying with the coordinates. Using familiar techniques, we compute the transport coefficients of the fluid dynamic derivative expansion to first order. We show how the shear and bulk viscosities are modified in the presence of electric charge and we compute the charge diffusion constant which is not present for the neutral black p-brane. We compute the first order dispersion relations of the effective fluid. For small values of the charge the speed of sound is found to be imaginary and the brane is thus Gregory-Laflamme unstable as expected. For sufficiently large values of the charge, the sound mode becomes stable, however, in this regime the hydrodynamic mode associated with charge diffusion is found to be unstable. The electrically charged brane is thus found to be (classically) unstable for all values of the charge density in agreement with general thermodynamic arguments. Finally, we show that the shear viscosity to entropy bound is saturated, as expected, while the proposed bounds for the bulk viscosity to entropy can be violated in certain regimes of the charge of the brane.Comment: 28 pages, 2 figure. v3: Small changes and a few typos correcte

Electroelasticity of Charged Black Branes

We present the first-order corrected dynamics of fluid branes carrying higher-form charge by obtaining the general form of their equations of motion to pole-dipole order. Assuming linear response theory, we characterize the corresponding effective theory of stationary bent charged (an)isotropic fluid branes in terms of two sets of response coefficients, the Young modulus and the piezoelectric moduli. We subsequently find large classes of examples in gravity of this effective theory, by constructing stationary strained charged black brane solutions to first order in a derivative expansion. Using solution generating techniques and bent neutral black branes as a seed solution, we obtain a class of charged black brane geometries carrying smeared Maxwell charge in Einstein-Maxwell-dilaton gravity. In the specific case of ten-dimensional space-time we furthermore use T-duality to generate bent black branes with higher-form charge, including smeared D-branes of type II string theory. By subsequently measuring the bending moment and the electric dipole moment which these geometries acquire due to the strain, we uncover that their form is captured by classical electroelasticity theory. In particular, we find that the Young modulus and the piezoelectric moduli of our strained charged black brane solutions are parameterized by a total of 4 response coefficients, both for the isotropic as well as anisotropic cases.Comment: v2: 40pp; typos fixe

Black Branes as Piezoelectrics

We find a realization of linear electroelasticity theory in gravitational physics by uncovering a new response coefficient of charged black branes, exhibiting their piezoelectric behavior. Taking charged dilatonic black strings as an example and using the blackfold approach we measure their elastic and piezolectric moduli. We also use our results to draw predictions about the equilibrium condition of charged dilatonic black rings in dimensions higher than six.Comment: v2: 9 pages; important sign corrections in section 3 and other minor corrections; published in PR

Probing the Hydrodynamic Limit of (Super)gravity

We study the long-wavelength effective description of two general classes of charged dilatonic (asymptotically flat) black p-branes including D/NS/M-branes in ten and eleven dimensional supergravity. In particular, we consider gravitational brane solutions in a hydrodynamic derivative expansion (to first order) for arbitrary dilaton coupling and for general brane and co-dimension and determine their effective electro-fluid-dynamic descriptions by exacting the characterizing transport coefficients. We also investigate the stability properties of the corresponding hydrodynamic systems by analyzing their response to small long-wavelength perturbations. For branes carrying unsmeared charge, we find that in a certain regime of parameter space there exists a branch of stable charged configurations. This is in accordance with the expectation that D/NS/M-branes have stable configurations, except for the D5, D6, and NS5. In contrast, we find that Maxwell charged brane configurations are Gregory-Laflamme unstable independently of the charge and, in particular, verify that smeared configurations of D0-branes are unstable. Finally, we provide a modification to the mapping presented in arxiv:1211.2815 and utilize it to provide a non-trivial cross-check on a certain subset of our transport coefficients with the results of arXiv:1110.2320.Comment: 36 pages, 2 figures. v2: Added reference and corrected typ

Holographic Models for Theories with Hyperscaling Violation

We study in detail a variety of gravitational toy models for hyperscaling-violating Lifshitz (hvLif) space-times. These space-times have been recently explored as holographic dual models for condensed matter systems. We start by considering a model of gravity coupled to a massive vector field and a dilaton with a potential. This model supports the full class of hvLif space-times and special attention is given to the particular values of the scaling exponents appearing in certain non-Fermi liquids. We study linearized perturbations in this model, and consider probe fields whose interactions mimic those of the perturbations. The resulting equations of motion for the probe fields are invariant under the Lifshitz scaling. We derive Breitenlohner-Freedman-type bounds for these new probe fields. For the cases of interest the hvLif space-times have curvature invariants that blow up in the UV. We study the problem of constructing models in which the hvLif space-time can have an AdS or Lifshitz UV completion. We also analyze reductions of Schroedinger space-times and reductions of waves on extremal (intersecting) branes, accompanied by transverse space reductions, that are solutions to supergravity-like theories, exploring the allowed parameter range of the hvLif scaling exponents.Comment: version 3: matches published versio

Effects of sodium butyrate on DNA content, glutathione S-transferase activities, cell morphology and growth characteristics of rat liver nonparenchymal epithelial cells in vitro

The effects of sodium butyrate, which has been shown to act as a differentiation promoting agent in several different tumor cell lines, were studied in a rat liver nonparenchymal epithelial cell line. Exposure of these cells to 3.75 mM butyrate resulted in an inhibition of cell proliferation and, at the same time, an increase in cell diameter (2- to 6-fold) and size of the nuclei (∼2-fold) after 3 days in culture. Binucleated cells arose, comprising ∼12% of the cells investigated, and the number of cells with an abnormal set of chromosomes was increased. Intercellular communication, measured by dye transfer of Lucifer Yellow, was unchanged. From the various xenobiotic metabolizing enzyme activities measured, only those of glutathione S-transferases were significantly altered (increases of 4- to 9-fold) by butyrate treatment. These increases were mainly due to the predominant rise in the π class isoenzyme which is a well-known tumour marker in rat hepatocarcinogenesis. Thus, our results cannot be interpreted as being either due to promotion of differentiation or due to transformation. The state and type of cell under study has to be considered and investigations of further differentiation parameters are needed to obtain a deeper insight into the biological activity and the underlying mechanisms of cell state modifying agents like butyrat

Simultaneous acquisition of PAR and PAIN spectra

We present a scheme that allows the simultaneous detection of PAR and PAIN correlation spectra in a single two-dimensional experiment. For both spectra, we obtain almost the same signal-to-noise ratio as if a PAR or PAIN spectrum is recorded separately, which in turn implies that one of the spectra may be considered additional information for free. The experiment is based on the observation that in a PAIN experiment, the PAR condition is always also fulfilled. The performance is demonstrated experimentally using uniformly 13C,15N-labeled samples of N-f-MLF-OH and ubiquiti

Making patient and public involvement in cancer and palliative care research a reality : academic support is vital for success

Objective: Patient and public involvement (PPI)has become an established theme within the UK health research policy and is recognised as an essential force in the drive to improve the quality of services and research. These developments have been particularly rapid in the cancer field. Methods: This paper outlines a model of PPI in research (known as the North Trent Cancer Research Network Consumer Research Panel, NTCRN CRP; comprising 38 cancer and palliative care patients/carers) and the key benefits and challenges to effective PPI in cancer research. Results: The PPI model has become a sustainable, inclusive and effective way of implementing PPI within the cancer context. Challenges include (1) a lack of time and funding available to support the PPI model; (2) tensions between different stakeholder groups when developing and conducting health research; (3) panel members finding it difficult to effectively integrate into research meetings when their role and contribution is not made clear at the outset or when unfamiliar language and jargon are used and not explained; (4) some professionals remain unclear about the role and practical implications of PPI in research. However, notwithstanding its financial and organisational challenges, the way that the NTCRN CRP is supported has provided a solid base for it to flourish. Conclusions: PPI provides considerable opportunities for patients and the public to work collaboratively with professionals to influence the cancer research agenda, with the contribution of PPI to the research process being integral to the entire process from the outset, rather than appended to it.</p