222 research outputs found
Oral malodor in Special Care Patients: current knowledge
Epidemiological studies report that about 50% of the population may have oral malodor
with a strong social and psychological impact in their daily life. When intra-oral causes are
excluded, referral to an appropriate medical specialist is paramount for management and
treatment of extra-oral causes. The intra-oral causes of halitosis are highly common, and the
dentist is the central clinician to diagnose and treat them. Pseudohalitosis or halitophobia
may occur and an early identification of these conditions by the dentist is important in order
to avoid unnecessary dental treatments for patients who need psychological or psychiatric
therapy. The organoleptic technique is still considered the most reliable examination method
to diagnose genuine halitosis. Special needs patients are more prone than others to have
oral malodor because of concurrent systemic or metabolic diseases, and medications.
The present report reviews halitosis, its implications, and the management in special care
dentistry
Hardware in the loop simulation of a dielectric elastomer generator for oscillating water column wave energy converters
Lion-porcupine interactions in Africa, including impacts on lion predatory behavior
Although African crested porcupines Hystrix spp. represent 0.5–34% of lion Panthera leo kills, interactions between the two species are poorly documented. Here we review porcupine-lion interactions and their impact on lion behaviour, including: 1) lion predation on porcupines; 2) lions injured or killed by porcupine quills; and 3) a case of a lion severely injured by a porcupine quill. Porcupine quills can be effective weapons and sometimes seriously wound lions, resulting in death. Death from quills can be a slow process and under these circumstances, death may be the result of starvation or infection (septicaemia).Keywords: predator-prey relations, quill, behaviour modification, Hayward-Kerley’ threat index, septicaemi
Endothelin-1[1–31], acting as an ETA-receptor selective agonist, stimulates proliferation of cultured rat zona glomerulosa cells
AbstractEndothelin-1 (ET-1)[1–31] is a novel hypertensive peptide that mimics many of the vascular effects of the classic 21 amino acid peptide ET-1[1–21]. However, at variance with ET-1[1–21] that enhances aldosterone secretion from cultured rat zona glomerulosa (ZG) cells by acting via ETB receptors, ET-1[1–31] did not elicit such effect. Both ET-1[1–21] and ET-1[1–31] raised the proliferation rate of cultured ZG cells, the maximal effective concentration being 10−8 M. This effect was blocked by the ETA-receptor antagonist BQ-123 and unaffected by the ETB-receptor antagonist BQ-788. Quantitative autoradiography showed that ET-1[1–21] displaced both [125I]PD-151242 binding to ETA receptors and [125I]BQ-3020 binding to ETB receptors in both rat ZG and adrenal medulla, while ET-1[1–31] displaced only [125I]BQ-3020 binding. The tyrosine kinase (TK) inhibitor tyrphostin-23 and the p42/p44 mitogen-activated protein kinase (MAPK) inhibitor PD-98059 abolished the proliferogenic effect of ET-1[1–31], while the protein kinase-C (PKC) inhibitor calphostin-C significantly reduced it. ET-1[1–31] (10−8 M) stimulated TK and MAPK activity of dispersed ZG cells, an effect that was blocked by BQ-123. The stimulatory action of ET-1[1–31] on TK activity was annulled by tyrphostin-23, while that on MAPK activity was reduced by calphostin-C and abolished by either tyrphostin-23 and PD-98059. These data suggest that ET-1[1–31] is a selective agonist of the ETA-receptor subtype, and enhances proliferation of cultured rat ZG cells through the PKC- and TK-dependent activation of p42/p44 MAPK cascade
Randomised comparison of subcutaneous heparin, intravenous heparin, and aspirin in unstable angina. Studio Epoorine sottocutanea nell'angina instabile (SESAIR) refrattorie group
Comparison of ambulatory blood pressure monitoring and conventional office measurement in the workers of a chemical company
Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons
The influx of calcium ions into the dendritic spines through the
N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for
various forms of synaptic plasticity. In this paper, the authors calculate
analytically the mean values of the calcium transients elicited by a spiking
neuron undergoing a simple model of ionic currents and back-propagating action
potentials. The relative variability of these transients, due to the stochastic
nature of synaptic transmission, is further considered using a simple Markov
model of NMDA receptos. One finds that both the mean value and the variability
depend on the timing between pre- and postsynaptic action-potentials. These
results could have implications on the expected form of synaptic-plasticity
curve and can form a basis for a unified theory of spike time-dependent, and
rate based plasticity.Comment: 14 pages, 10 figures. A few changes in section IV and addition of a
new figur
Cardiac angiotensin II formation in the clinical course of heart failure and its relationship with left ventricular function.
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