Kinetic or thermal AGN feedback in simulations of isolated and merging disc galaxies calibrated by the M-\ua0 relation

We investigate two modes of coupling the feedback energy from a central active galacticnucleus (AGN) to the neighbouring gas in galaxy simulations: kinetic - velocity boost andthermal - heating. We formulate kinetic feedback models for energy-driven wind (EDW)and momentum-driven wind (MDW), using two free parameters: feedback efficiency \u3b5f and AGN wind velocity \u3bd w. A novel numerical algorithm is implemented in the smoothed particlehydrodynamics code GADGET-3, to prevent the expansion of a hole in the gas distributionaround the black hole (BH). We perform simulations of isolated evolution and merger ofdisc galaxies, of Milky Way mass as well as lower and higher masses. We find that in theisolated galaxy BH kinetic feedback generates intermittent bipolar jet-like gas outflows. Weinfer that current prescriptions for BH subgrid physics in galaxy simulations can grow theBH to observed values even in an isolated disc galaxy. The BH growth is enhanced in agalaxy merger, which consequently requires different model parameters to fit the observationsthan an isolated case. Comparing the [MBH-\u3c3*] relation obtained in our simulations withobservational data, we conclude that it is possible to find parameter sets for a fit in all themodels (e.g. \u3bdw = 10 000 km s-1 and \u3b5f = 0.25 for BH kinetic EDW), except for the casewith MDW feedback in a galaxy merger, in which the BH is always too massive. The BHthermal feedback implementation of Springel et al. within the multiphase star formation modelis found to have negligible impact on gas properties, and the effect claimed in all previousstudies is attributed to gas depletion around the BH by the creation of an artificial hole. TheBH mass accretion rate in our simulations exhibit heavy fluctuations. The star formation rate isquenched with feedback by removal of gas. The circumgalactic medium gas at galactocentricdistances (20-100) h-1 kpc is found to give the best metallicity observational diagnostic todistinguish between BH model

Laparoscopic single-port sleeve gastrectomy for morbid obesity: preliminary series

Laparoscopic sleeve gastrectomy has been recently proposed as a sole bariatric procedure because of the resulting considerable weight loss in morbidly obese patients. Traditionally, laparoscopic sleeve gastrectomy requires 5-6 skin incisions to allow for placement of multiple trocars. With the introduction of single-incision laparoscopic surgery, multiple abdominal procedures have been performed using a sole umbilical incision, with good cosmetic outcomes. The purpose of our study was to evaluate the feasibility and safety of laparoscopic single incision sleeve gastrectomy for morbid obesity

Expressão gênica em grãos de café submetidos a diferentes tratamentos pós-colheita-uma análise preliminar.

O conhecimento sobre como os tipos de processamento pós-colheita interferem na qualidade final de bebida é essencial para que cafés com qualidades especiais possam ser desenvolvidos. Dentre as características que podem ser diretamente influenciadas pelo processamento, a composição química do grão é a de maior interesse. Fatores como a regulação da expressão de genes e a atividade de enzimas específicas são determinantes para esta composição. Neste contexto, o objetivo deste estudo preliminar foi avaliar como os processamentos por via seca e úmida afetam o padrão de expressão dos genes isocitrato liase (ICL), ?-mananase (MAN) e ?-galactosidase (GAL). Frutos cereja foram submetidos a condições de secagem natural, despolpamento e desmucilamento. A expressão dos genes foi quantificada pela metodologia de RT-PCR em tempo real. A análise comparativa da expressão dos 3 genes indicou que no processamento via seca a expressão de ICL e MAN nas sementes foi maior do que em sementes de frutos processados por via úmida. Para o gene GAL, não foram observadas diferenças expressivas no perfil de expressão em sementes dos frutos submetidos aos diferentes tratamentos. Esses resultados diferiram dos obtidos em outros estudos já descritos na literatura, em que, apesar de ter sido avaliada a expressão de genes, foram utilizadas etapas de processamento distintas das utilizadas neste trabalho. Esses resultados revelaram, portanto, que há necessidade de se padronizarem os processamentos experimentais em pesquisas visando avaliar efeitos dos tratamentos pós-colheita sobre a qualidade do café

Cosmological hydrodynamical simulations of galaxy clusters: X-ray scaling relations and their evolution

We analyse cosmological hydrodynamical simulations of galaxy clusters to study the X-ray scaling relations between total masses and observable quantities such as X-ray luminosity, gas mass, X-ray temperature, and $Y_{X}$. Three sets of simulations are performed with an improved version of the smoothed particle hydrodynamics GADGET-3 code. These consider the following: non-radiative gas, star formation and stellar feedback, and the addition of feedback by active galactic nuclei (AGN). We select clusters with $M_{500} > 10^{14} M_{\odot} E(z)^{-1}$, mimicking the typical selection of Sunyaev-Zeldovich samples. This permits to have a mass range large enough to enable robust fitting of the relations even at $z \sim 2$. The results of the analysis show a general agreement with observations. The values of the slope of the mass-gas mass and mass-temperature relations at $z=2$ are 10 per cent lower with respect to $z=0$ due to the applied mass selection, in the former case, and to the effect of early merger in the latter. We investigate the impact of the slope variation on the study of the evolution of the normalization. We conclude that cosmological studies through scaling relations should be limited to the redshift range $z=0-1$, where we find that the slope, the scatter, and the covariance matrix of the relations are stable. The scaling between mass and $Y_X$ is confirmed to be the most robust relation, being almost independent of the gas physics. At higher redshifts, the scaling relations are sensitive to the inclusion of AGNs which influences low-mass systems. The detailed study of these objects will be crucial to evaluate the AGN effect on the ICM.Comment: 24 pages, 11 figures, 5 tables, replaced to match accepted versio

Ligation of the intersphincteric fistula tract (LIFT) to treat anal fistula: early results from a prospective observational study

Ligation of the intersphincteric tract (LIFT), a novel sphincter-saving technique, has been recently described with promising results. Literature data are still scant. In this prospective observational study, we present our experience with this technique

A GEO-DATABASE FOR 3D-AIDED MULTI-EPOCH DOCUMENTATION OF BRIDGE INSPECTIONS

The recent collapse of bridges in Italy has prompted numerous studies on monitoring and maintenance. Many structures in Italy have been in service for over 50 years, necessitating new approaches to ensure their safety. To address this issue, Italy's Consiglio Superiore dei Lavori Pubblici (Superior Council of Public Works) has developed the Guidelines for Risk Classification and Management, proposing a multi-level approach to bridge management within a complex geomorphological environment. The guidelines outline a multi-level process that includes surveying the structures, conducting detailed inspections, and assigning risk classes based on hazard, exposure, and vulnerability. Current inspection processes are time-consuming and costly. Therefore, alternative monitoring technologies are crucial. Unmanned aerial vehicles equipped with cameras, laser technologies, and GPS systems offer flexible and cost-effective solutions for visual inspection. These technologies enable the collection of both quantitative and qualitative data, such as size, material properties, and overall condition. In this context, efficient data management and exploration systems are necessary to handle the vast amount of geo-referenced information. Multi-epoch databases play a crucial role in documenting the conditions of bridges and supporting a maintenance and structural health monitoring workflow. These databases can be utilized within a Bridge Management System to aid road managers in decision-making processes. Additionally, 3D exploration platforms provide visual analysis and highlight areas of interest within the structure. This work presents a multi-epoch geo-database that adheres to the Italian guidelines, offering optimized data management and queryability for 2D and 3D information. The entire process is designed using open-source and reproducible solutions

Role of 0.4% glyceryl trinitrate ointment after haemorrhoidectomy: results of a prospective randomised study

INTRODUCTION: Conventional haemorrhoidectomy (CH) is well known to cause significant post-operative pain and delayed return to daily activities. Both surgical wounds and sphincterial apparatus spasms are likely responsible for the pain. In this study, we evaluated the role of glyceryl trinitrate ointment (GTN) in reducing post-operative pain, ameliorating wound healing and recovery after CH. PATIENTS AND METHODS: Between 01/08 and 12/11, 203 patients with symptomatic haemorrhoids were enrolled in the study and received (103 patients) or not (100 patients) 0.4 % GTN ointment for 6 weeks after surgery. Pain was assessed using a 10-cm linear visual analogue scale (VAS). Data on post-operative pain, wound secretion and bleeding, return to normal activities and complications were recorded. Data were analysed using Fisher's exact and Mann-Whitney tests. RESULTS: GTN-treated group experienced significantly less pain during the first week after surgery (p < 0.0001). This difference was more evident starting from post-operative day 4 (p < 0.0001). A significant higher percentage of untreated patients experienced severe pain (mean VAS score > 7) (10 % vs 31 %). There were significant differences in terms of secretion time (p = 0.0052) and bleeding time (p = 0.02) in favor of GTN. In addition, the duration of itching was less in the GTN group (p = 0.0145). Patients treated with GTN were able to an early return to daily activities compared to untreated (p < 0.0001). Fifteen GTN-treated patients (14.6 %) discontinued the application because of local discomfort and headache. CONCLUSIONS: GTN ointment enhances significantly post-operative recovery, reducing pain in terms of duration and intensity. This effect might be secondary to a faster wound healing expressed by reduced secretion, bleeding and itching time

Allergens and Irritants Transcriptionally Upregulate CD80 Gene Expression in Human Keratinocytes

The human CD80 costimulatory molecule is an important signal between professional antigen-presenting cells and T helper cells. The immunobiology of CD80 expression by keratinocytes, especially during allergic and irritant contact dermatitis, however, is less well understood. CD80 cell surface expression and gene transcription by keratinocytes was increased when keratinocytes were exposed to certain allergens (chemicals that induce inflammation via hapten-specific T cells) and irritants (chemicals that are toxic to epidermal cells). Therefore, the human CD80 promoter was cloned and luciferase reporter constructs containing various promoter fragments were engineered. Promoter mapping of these CD80 constructs in transiently transfected keratinocytes showed that a construct containing the proximal 231 bp immediately upstream of the transcription start site of the CD80 promoter was most active in keratinocytes and was inducible to a level ranging from 2- to 10-fold higher in keratinocytes treated with certain allergens and irritants, compared with untreated keratinocytes. This pattern of promoter fragment activity in keratinocytes is identical to that found in professional antigen-presenting cells. This is the first demonstration that the CD80 promoter is active in keratinocytes and that this activity is further increased in keratinocytes treated with certain allergens and irritants. These data suggest that allergens and irritants may, in part, break peripheral tolerance by their direct effects on keratinocyte costimulatory molecule expression, thereby facilitating interactions with epidermotropic T helper cells via the CD80–CD28 or CTLA-4 pathways