El campeonato de F1 desde la óptica de la función de producción

Este trabajo se dirige a la estimación y análisis de la función de producción del campeonato de Formula 1. De esta forma, se busca desarrollar un estudio basado en la maximización del total de puntos obtenidos a lo largo de toda la temporada en función de una serie de variables. Consecuentemente, el modelo que se ha desarrollado se sigue de una variable dependiente que, en estos casos, son los puntos obtenidos al final de cada una de las temporadas (temporada 2016, 2017 y 2018). Por su parte, las variables independientes se corresponden con el presupuesto con el que cuenta cada equipo para cada una de las temporadas, además del número de trabajadores que de forma directa trabajan para el equipo de F1 durante una temporada entera. Además de recoger todos los datos necesarios para la elaboración de estos modelos, se han recopilado otros, de forma detallada, que sirven de apoyo para entender y contextualizar en qué situación ha estado el campeonato de la F1 durante todas estas temporadas. Así, se han recolectado datos tanto por equipos como por pilotos para conseguir un análisis mucho más pormenorizado.<br /

La movilidad geográfica en el ámbito laboral

TFG en el que se aborda la movilidad geográfica tanto desde el punto de vista del empresario como desde el punto de vista del trabajador (con sus correspondientes vicisitudes). Se estudiará, igualmente, la relación que existe entre la movilidad geográfica y los cambios sustanciales de las condiciones de trabajo y se tratarán también las posibles especialidades que ofrece la aplicación de la movilidad geográfica en supuestos singulares.<br /

Procesos de una auditoría

La memoria de mi trabajo de fin de Máster de Auditoría que expondré a continuación haráreferencia a los conceptos y conocimientos que he ido adquiriendo a lo largo del cursoacadémico, complementado con un periodo de prácticas en la firma de auditoría AUREN. Endicha memoria se analizarán las fases y los procesos de auditoría en los que he participado ypuesto en práctica durante este periodo. Estos procesos se centran en la fase de ejecución deuna auditoría, es decir, la realización de papeles de trabajo y obtención de evidencias yconclusiones.Cada uno de estos procesos, realizados en la fase de ejecución para cada una de las áreas de lasociedad, documentados con sus correspondientes papeles de trabajo, sumados al trabajoprevio realizado por los jefes de equipo, como por ejemplo, en la fase de planificación, haránposible obtener conclusiones al equipo de auditoría acerca de la situación en la que seencuentra la sociedad y así poder emitir un informe de auditoría, expresando una opinión,indicando si las cuentas de la sociedad reflejan una imagen fiel.<br /

Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease

This work evaluated a serial blood sampling procedure to enhance the sensitivity of duplex real-time quantitative PCR (qPCR) for baseline detection and quantification of parasitic loads and posttreatment identification of failure in the context of clinical trials for treatment of chronic Chagas disease, namely, DNDi-CHE1224-001 (ClinicalTrials.gov registration no. NCT01489228) and the MSF-DNDi PCR Sampling Optimization Study (NCT01678599). Patients from Cochabamba (n 294), Tarija (n 257), and Aiquile (n 220) were enrolled. Three serial blood samples were collected at each time point, and qPCR triplicates were tested for each sample. The first two samples were collected during the same day and the third one 7 days later. A patient was considered PCR positive if at least one qPCR replicate was detectable. Cumulative results of multiple samples and qPCR replicates enhanced the proportion of pretreatment sample positivity from 54.8% to 76.2%, 59.5% to 77.8%, and 73.5% to 90.2% in Cochabamba, Tarija, and Aiquile cohorts, respectively. This strategy increased the detection of treatment failure from 72.9% to 91.7%, 77.8% to 88.9%, and 42.9% to 69.1% for E1224 low-, short-, and high-dosage regimens, respectively, and from 4.6% to 15.9% and 9.5% to 32.1% for the benznidazole arm in the DNDi-CH-E1224-001 and MSF-DNDi studies, respectively. The addition of the third blood sample and third qPCR replicate in patients with nondetectable PCR results in the first two samples gave a small, non-statistically significant improvement in qPCR positivity. No change in clinical sensitivity was seen with a blood volume increase from 5 to 10 ml. The monitoring of patients treated with placebo in the DNDi-CH-E1224-001 trial revealed fluctuations in parasitic loads and occasionally nondetectable results. In conclusion, a serial sampling strategy enhanced PCR sensitivity to detecting treatment failure during follow-up and has the potential for improving recruitment capacity in Chagas disease trials, which require an initial positive qPCR result for patient admission

Study of the ψ 2(3823) and χ c1(3872) states in B+ → (J/ψπ + π −)K+ decays

The decays B+ → J/ψπ+π−K+ are studied using a data set corresponding to an integrated luminosity of 9 fb−1 collected with the LHCb detector in proton-proton collisions between 2011 and 2018. Precise measurements of the ratios of branching fractions with the intermediate ψ2(3823), χc1(3872) and ψ(2S) states are reported. The values are BB+→ψ2(3823)K+×Bψ2(3823)→J/ψπ+π−BB+→χc1(3872)K+×Bχc1(3872)→J/ψπ+π−=(3.56±0.67±0.11)×10−2,BB+→ψ2(3823)K+×Bψ2(3823)→J/ψπ+π−BB+→ψ(2S)K+×Bψ(2S)→J/ψπ+π−=(1.31±0.25±0.04)×10−3,BB+→χc1(3872)K+×Bχc1(3872)→J/ψπ+π−BB+→ψ(2S)K+×Bψ(2S)→J/ψπ+π−=(3.69±0.07±0.06)×10−2, where the first uncertainty is statistical and the second is systematic. The decay of B+ → ψ2(3823)K+ with ψ2(3823) → J/ψπ+π− is observed for the first time with a significance of 5.1 standard deviations. The mass differences between the ψ2(3823), χc1(3872) and ψ(2S) states are measured to be mχc1(3872)−mψ2(3823)=47.50±0.53±0.13MeV/c2,mψ2(3823)−mψ2(2S)=137.98±0.53±0.14MeV/c2,mχc1(3872)−mψ2(2S)=185.49±0.06±0.03MeV/c2, resulting in the most precise determination of the χc1(3872) mass. The width of the ψ2(3823) state is found to be below 5.2 MeV at 90% confidence level. The Breit-Wigner width of the χc1(3872) state is measured to be ΓBWχc1(3872)=0.96+0.19−0.18±0.21MeV which is inconsistent with zero by 5.5 standard deviations

Measurement of the shape of the Bs0→Ds∗−μ+νμ differential decay rate

The shape of the B0s→D∗−sμ+νμ differential decay rate is obtained as a function of the hadron recoil parameter using proton-proton collision data at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.7 fb−1 collected by the LHCb detector. The B0s→D∗−sμ+νμ decay is reconstructed through the decays D∗−s→D−sγ and D−s→K−K+π−. The differential decay rate is fitted with the Caprini-Lellouch-Neubert (CLN) and Boyd-Grinstein-Lebed (BGL) parametrisations of the form factors, and the relevant quantities for both are extracted

Observation of the semileptonic decay B+→ pp¯ μ+νμ

The Cabibbo-suppressed semileptonic decay B+→pp¯¯¯μ+νμ is observed for the first time using a sample of pp collisions corresponding to an integrated luminosity of 1.0, 2.0 and 1.7 fb−1 at centre-of-mass energies of 7, 8 and 13 TeV, respectively. The differential branching fraction is measured as a function of the pp¯¯¯ invariant mass using the decay mode B+ → J/ψK+ for normalisation. The total branching fraction is measured to be B(B+→pp¯¯¯μ+νμ)= (5.27+0.23−0.24±0.21±0.15)×10−6, where the first uncertainty is statistical, the second systematic and the third is from the uncertainty on the branching fraction of the normalisation channel

Searches for low-mass dimuon resonances

Searches are performed for a low-mass dimuon resonance, X, produced in proton-proton collisions at a center-of-mass energy of 13 TeV, using a data sample corresponding to an integrated luminosity of 5.1 fb−1 and collected with the LHCb detector. The X bosons can either decay promptly or displaced from the proton-proton collision, where in both cases the requirements placed on the event and the assumptions made about the production mechanisms are kept as minimal as possible. The searches for promptly decaying X bosons explore the mass range from near the dimuon threshold up to 60 GeV, with nonnegligible X widths considered above 20 GeV. The searches for displaced X → μ+μ− decays consider masses up to 3 GeV. None of the searches finds evidence for a signal and 90% confidence-level exclusion limits are placed on the X → μ+μ− cross sections, each with minimal model dependence. In addition, these results are used to place world-leading constraints on GeV-scale bosons in the two-Higgs-doublet and hidden-valley scenarios

Measurement of branching fraction ratios for B + → D *+ D − K +, B + → D *− D + K +, and B 0 → D *− D 0 K + decays

A measurement of four branching-fraction ratios for three-body decays of B mesons involving two open-charm hadrons in the final state is presented. Run 1 and Run 2 pp collision data are used, recorded by the LHCb experiment at centre-of-mass energies 7, 8, and 13 TeV and corresponding to an integrated luminosity of 9 fb−1. The measured branching-fraction ratios are B(B+→D∗+D−K+)B(B+→D¯¯¯¯¯0D0K+)=0.517±0.015±0.013±0.011,B(B+→D∗−D+K+)B(B+→D¯¯¯¯¯0D0K+)=0.577±0.016±0.013±0.013,B(B0→D∗−D0K+)B(B0→D−D0K+)=1.754±0.028±0.016±0.035,B(B+→D∗+D−K+)B(B+→D∗−D+K+)=0.907±0.033±0.014,where the first of the uncertainties is statistical, the second systematic, and the third is due to the uncertainties on the D-meson branching fractions. These are the most accurate measurements of these ratios to date

Measurement off f(s)/f(u) Variation with Proton-Proton Collision Energy and B-Meson Kinematics

The ratio of the B0s and B+ fragmentation fractions fs and fu is studied with B0s→J/ψϕ and B+→J/ψK+ decays using data collected by the LHCb experiment in proton-proton collisions at 7, 8, and 13 TeV center-of-mass energies. The analysis is performed in bins of B-meson momentum, longitudinal momentum, transverse momentum, pseudorapidity, and rapidity. The fragmentation-fraction ratio fs/fu is observed to depend on the B-meson transverse momentum with a significance of 6.0σ. This dependency is driven by the 13 TeV sample (8.7σ), while the results for the other collision energies are not significant when considered separately. Furthermore, the results show a 4.8σ evidence for an increase of fs/fu as a function of collision energy