Colliding Kaluza-Klein Bubbles

We construct an exact solution describing the collision of two Kaluza-Klein "bubbles of nothing" in 3+1 dimensions. When the bubbles collide, a curvature singularity forms which is hidden inside an event horizon. However, unlike the formation of ordinary black holes, in this case the spacetime resembles the entire maximally extended Schwarzschild solution. We also point out that there are inequivalent bubbles that can be constructed from Kerr black holes.Comment: 20 pages, v2: minor error correcte

Uniqueness and non-uniqueness of static vacuum black holes in higher dimensions

We prove the uniqueness theorem for asymptotically flat static vacuum black hole solutions in higher dimensional space-times. We also construct infinitely many non-asymptotically flat regular static black holes on the same spacetime manifold with the same spherical topology.Comment: to appear in Progress of Theoretical Physics Supplement No. 14

Rotating Black Holes which Saturate a Bogomol'nyi Bound

We construct and study the electrically charged, rotating black hole solution in heterotic string theory compactified on a $(10-D)$ dimensional torus. This black hole is characterized by its mass, angular momentum, and a $(36-2D)$ dimensional electric charge vector. One of the novel features of this solution is that for $D >5$, its extremal limit saturates the Bogomol'nyi bound. This is in contrast with the $D=4$ case where the rotating black hole solution develops a naked singularity before the Bogomol'nyi bound is reached. The extremal black holes can be superposed, and by taking a periodic array in $D>5$, one obtains effectively four dimensional solutions without naked singularities.Comment: 13 pages, no figure

Uniqueness of (dilatonic) charged black holes and black p-branes in higher dimensions

We prove the uniqueness of higher dimensional (dilatonic) charged black holes in static and asymptotically flat spacetimes for arbitrary vector-dilaton coupling constant. An application to the uniqueness of a wide class of black p-branes is also given.Comment: 6 page

Self-tuning in an Outgoing Brane Wave Model

We introduce a new brane-world model in which the bulk solution consists of outgoing plane waves. This is an exact solution to string theory with no naked singularities. The recently discussed self-tuning mechanism to cancel the cosmological constant on a brane is naturally incorporated. We show that even if the vacuum energy on the brane changes, e.g. due to a phase transition, the brane geometry remains insensitive to the local vacuum energy. We also consider the static self-tuning branes introduced earlier, and find a solution in which the brane geometry starts to contract when the vacuum energy on the brane changes.Comment: 20 pages, 3 figures, latex; v2: minor correction and reference adde

The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study

Background Nationally, symptomatic heart failure affects 1.5-2% of Canadians, incurs $3 billion in hospital costs annually and the global burden is expected to double in the next 1–2 decades. The current one-year mortality rate after diagnosis of heart failure remains high at >25%. Consequently, new therapeutic strategies need to be developed for this debilitating condition. Methods/Design The objective of the Alberta HEART program (http://albertaheartresearch.ca) is to develop novel diagnostic, therapeutic and prognostic approaches to patients with heart failure with preserved ejection fraction. We hypothesize that novel imaging techniques and biomarkers will aid in describing heart failure with preserved ejection fraction. Furthermore, the development of new diagnostic criteria will allow us to: 1) better define risk factors associated with heart failure with preserved ejection fraction; 2) elucidate clinical, cellular and molecular mechanisms involved with the development and progression of heart failure with preserved ejection fraction; 3) design and test new therapeutic strategies for patients with heart failure with preserved ejection fraction. Additionally, Alberta HEART provides training and education for enhancing translational medicine, knowledge translation and clinical practice in heart failure. This is a prospective observational cohort study of patients with, or at risk for, heart failure. Patients will have sequential testing including quality of life and clinical outcomes over 12 months. After that time, study participants will be passively followed via linkage to external administrative databases. Clinical outcomes of interest include death, hospitalization, emergency department visits, physician resource use and/or heart transplant. Patients will be followed for a total of 5 years. Discussion Alberta HEART has the primary objective to define new diagnostic criteria for patients with heart failure with preserved ejection fraction. New criteria will allow for targeted therapies, diagnostic tests and further understanding of the patients, both at-risk for and with heart failure

Avpr1a variant associated with preschoolers' lower altruistic behavior

10.1371/journal.pone.0025274PLoS ONE69

The Oxytocin Receptor (OXTR) Contributes to Prosocial Fund Allocations in the Dictator Game and the Social Value Orientations Task

Background: Economic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. Methodology/Principal Findings: Association (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p = 0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2–5 locus haplotypes (p,0.05). A second sample of 98 female subjects was subsequently and independently recruited to play the dictator game and was genotyped for the three significant SNPs found in the first sample. The rs1042778 SNP was shown to be significant for the second sample as well (p = 0.004, Fisher’s exact test). Conclusions: The demonstration that genetic polymorphisms for the OXTR are associated with human prosocial decisio

Economic Analysis of Knowledge: The History of Thought and the Central Themes

Following the development of knowledge economies, there has been a rapid expansion of economic analysis of knowledge, both in the context of technological knowledge in particular and the decision theory in general. This paper surveys this literature by identifying the main themes and contributions and outlines the future prospects of the discipline. The wide scope of knowledge related questions in terms of applicability and alternative approaches has led to the fragmentation of research. Nevertheless, one can identify a continuing tradition which analyses various aspects of the generation, dissemination and use of knowledge in the economy