A predicted dimer-based polymorph of 10,11-dihydrocarbamazepine (Form IV)

A novel polymorph of 10,11-dihydrocarbamazepine (form IV), which had been predicted to be thermodynamically feasible, was obtained from the vapour phase and displays an R22(8) hydrogen bonded dimer motif in contrast to the catemeric motifs in forms I–III

Ensnaring the Elusive Eodermdrome

We wish to introduce the recreational aspects of the eodermdrome, which is a recently formulated concept dealing with the structure of language units such as letters and words. Although this concept may eventually lead to a numerical way to compare the structural differences between languages and to trace structural development in a single language, the majority of individuals who learn about eodermdromes evince less interest in their potential scholarly ramifications than in the delightful task of creating them

Inflatable Structures Technology Handbook

The technologies required to design, fabricate, and utilize an inflatable module for space applications has been demonstrated and proven by the TransHab team during the development phase of the program. Through testing and hands-on development several issues about inflatable space structures have been addressed , such as: ease of manufacturing, structural integrity, micrometeorite protection, folding , and vacuum deployment. The TransHab inflatable technology development program has proven that not only are inflatable structures a viable option, but they also offer significant advantages over conventional metallic structures

Diethyl 3,4-dimethylthieno[2,3-it b]thiophene-2,5-dicarboxylate

In the title compound, C14H16O4S2, the thieno[2,3-b]thiophene ring systems are planar [maximum deviation = 0.008 (2) Å]. The molecular conformation is stabilized by intramolecular C-HO hydrogen bonds, while the crystal packing is stabilized by C-HO, C-H and - stacking [centroid-centroid distance = 3.6605 (14) Å] interactions, which lead to supramolecular layers in the ab plane

Unexpected selective gas adsorption on a 'non-porous' metal organic framework

A metal organic framework Cu(tpt)BF 4· 3 4 H 2O was synthesized as a potential carbon capture material, with the aim being to exploit the Lewis base interaction of the incorporated ligand functionalities with acidic gas. The material displays high thermal stability but an exceptionally low surface area; however, this contrasts starkly with its ability to capture carbon dioxide, demonstrating significant activated diffusion within the framework. The full characterization of the material shows a robust structure, where the CO 2 sorption is 120% greater than current industrial methods using liquid amine solutions; the thermal energy required for sorbent regeneration is reduced by 65%, indicating the true industrial potential of the synthesized material

A Waterborne Outbreak of Escherichia coli O157:H7 Infections and Hemolytic Uremic Syndrome: Implications for Rural Water Systems1

In the summer of 1998, a large outbreak of Escherichia coli O157:H7 infections occurred in Alpine, Wyoming. We identified 157 ill persons; stool from 71 (45%) yielded E. coli O157:H7. In two cohort studies, illness was significantly associated with drinking municipal water (town residents: adjusted odds ratio=10.1, 95% confidence intervals [CI]=1.8-56.4; visitors attending family reunion: relative risk=9.0, 95% CI=1.3-63.3). The unchlorinated water supply had microbiologic evidence of fecal organisms and the potential for chronic contamination with surface water. Among persons exposed to water, the attack rate was significantly lower in town residents than in visitors (23% vs. 50%, p<0.01) and decreased with increasing age. The lower attack rate among exposed residents, especially adults, is consistent with the acquisition of partial immunity following long-term exposure. Serologic data, although limited, may support this finding. Contamination of small, unprotected water systems may be an increasing public health risk

Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer\u27s disease

INTRODUCTION: Clinical trials for sporadic Alzheimer\u27s disease generally use mixed models for repeated measures (MMRM) or, to a lesser degree, constrained longitudinal data analysis models (cLDA) as the analysis model with time since baseline as a categorical variable. Inferences using MMRM/cLDA focus on the between-group contrast at the pre-determined, end-of-study assessments, thus are less efficient (eg, less power). METHODS: The proportional cLDA (PcLDA) and proportional MMRM (pMMRM) with time as a categorical variable are proposed to use all the post-baseline data without the linearity assumption on disease progression. RESULTS: Compared with the traditional cLDA/MMRM models, PcLDA or pMMRM lead to greater gain in power (up to 20% to 30%) while maintaining type I error control. DISCUSSION: The PcLDA framework offers a variety of possibilities to model longitudinal data such as proportional MMRM (pMMRM) and two-part pMMRM which can model heterogeneous cohorts more efficiently and model co-primary endpoints simultaneously

Intercomparison of long-term sea surface temperature analyses using the GHRSST Multi-Product Ensemble (GMPE) system

Six global, gridded, gap-free, daily sea surface temperature (SST) analyses covering a period of at least 20 years have been intercompared: ESA SST CCI anal- ysis long-term product v1.0, MyOcean OSTIA reanalysis v1.0, CMC 0.2 degree, AVHRR ONLY Daily 1/4 degree OISST v2.0, HadISST2.1.0.0 and MGDSST. A seventh SST product of the ensemble median of all six has also been produced using the GMPE (Group for High Resolution SST Multi-Product Ensemble) sys- tem. Validation against independent near-surface Argo data, a long timeseries of moored buoy data from the tropics and anomalies to the GMPE median have been used to examine the temporal and spatial homogeneity of the analyses. A comparison of the feature resolution of the analyses has also been undertaken. A summary of relative strengths and weaknesses of the SST datasets is presented, intended to help users to make an informed choice of which analysis is most suitable for their proposed application

The Grizzly, February 2, 1979

Frat Beating Draws Administrative Fire • New Frat Gathers Steam • Holiday Thefts: Negligence or Lack of Concern? • In Memoriam • Judiciary Board Revival • Cultural Kaleidoscope • Letters to the Editor: Snack shop complaint • Roving Reporter: Greaseband opinions • Dishroom Profile: Roy Schuetz, Man or Myth? • Grease Is The Word • Nicolette Larson Debuts In Style • USGA Elections • Portrait of the Professor: Dr. Conrad E. Kruse • Raquetball Review • Bio Club Spawned • R.A. Applications Available; Ruby Seeks Editor • Gymnasts Place Third In Tourney • Bears Turning Corner • Slavin Breaks Record Mermaids Lose • Wrestlers Manhandle Mules • Badminton Drops Onehttps://digitalcommons.ursinus.edu/grizzlynews/1011/thumbnail.jp

Habitat Demonstration Unit (HDU) Vertical Cylinder Habitat

NASA's Constellation Architecture Team defined an outpost scenario optimized for intensive mobility that uses small, highly mobile pressurized rovers supported by portable habitat modules that can be carried between locations of interest on the lunar surface. A compact vertical cylinder characterizes the habitat concept, where the large diameter maximizes usable flat floor area optimized for a gravity environment and allows for efficient internal layout. The module was sized to fit into payload fairings for the Constellation Ares V launch vehicle, and optimized for surface transport carried by the All-Terrain Hex-Limbed Extra-Terrestrial Explorer (ATHLETE) mobility system. Launch and other loads are carried through the barrel to a top and bottom truss that interfaces with a structural support unit (SSU). The SSU contains self-leveling feet and docking interfaces for Tri-ATHLETE grasping and heavy lift. A pressurized module needed to be created that was appropriate for the lunar environment, could be easily relocated to new locations, and could be docked together in multiples for expanding pressurized volume in a lunar outpost. It was determined that horizontally oriented pressure vessels did not optimize floor area, which takes advantage of the gravity vector for full use. Hybrid hard-inflatable habitats added an unproven degree of complexity that may eventually be worked out. Other versions of vertically oriented pressure vessels were either too big, bulky, or did not optimize floor area. The purpose of the HDU vertical habitat module is to provide pressurized units that can be docked together in a modular way for lunar outpost pressurized volume expansion, and allow for other vehicles, rovers, and modules to be attached to the outpost to allow for IVA (intra-vehicular activity) transfer between them. The module is a vertically oriented cylinder with a large radius to allow for maximal floor area and use of volume. The modular, 5- m-diameter HDU vertical habitat module consists of a 2-m-high barrel with 0.6-mhigh end domes forming the 56-cubicmeter pressure vessel, and a 19-squaremeter floor area. The module has up to four docking ports located orthogonally from each other around the perimeter, and up to one docking port each on the top or bottom end domes. In addition, the module has mounting trusses top and bottom for equipment, and to allow docking with the ATHLETE mobility system. Novel or unique features of the HDU vertical habitat module include the nodelike function with multiple pressure hatches for docking with other versions of itself and other modules and vehicles; the capacity to be carried by an ATHLETE mobility system; and the ability to attach inflatable 'attic' domes to the top for additional pressurized volume