Report of the Committee on Administration of Justice

Three major matters were referred to this committee during the year. First, the matter of an additional federal judge for the Western District of Washington. Second, the creation of an Eleventh Circuit Court of Appeals consisting of Washington, Oregon, Idaho and Montana and the Territory of Alaska. Third, the method of selecting of judges, with particular consideration of the Missouri type plan

Letter from P.C. Garvin, M.D. to Governor Coburn offering medical services, August 12, 1863

https://digitalmaine.com/adj_gen_corr_town_acton/1008/thumbnail.jp

Letter from P.C. Garvin, M.D. to Governor Washburn offering medical services, July 3, 1862

https://digitalmaine.com/adj_gen_corr_town_acton/1003/thumbnail.jp

Activity of glycolytic enzymes in the gut of Hormogaster elisae (Oligochaeta, Hormogastridae)

The glycolytic enzymatic activities in the gut of the endogeic earthworm #Hormogaster elisae from El Molar (Madrid, Spain) were studied in order to determine its digestive capacity and to assess its alimentary regime. Most endogeic earthworms have weak enzymatic complement and they usually establish mutualistic relationships with soil microflora to digest some organic compounds. Therefore, the intestinal wall tissues were cultured in vitro to assess the origin of the glycolytic enzymes found in the gut and enzymatic activities were measured in both cultured tissues and culture media. #H. elisae had a wide but not very strong enzyme complement, since all substrates were degraded but most of them at a low rate. This species cannot produce cellulase and mannamase, so for the digestion of these substrates it probably uses the digestive enzymatic capabilities of the ingested microflora. (Résumé d'auteur

Relatives\u27 Responsibility Law Requiring Financially Able Adult Children to Contribute to the Support of Their Needy Parents Has a Rational Relation to a Conceivably Legitimate State Purpose and Does Not Transgress the Constitutional Equal Protection Guarantee.

Abstract Forthcoming

Joint Segmentation and Uncertainty Visualization of Retinal Layers in Optical Coherence Tomography Images using Bayesian Deep Learning

Optical coherence tomography (OCT) is commonly used to analyze retinal layers for assessment of ocular diseases. In this paper, we propose a method for retinal layer segmentation and quantification of uncertainty based on Bayesian deep learning. Our method not only performs end-to-end segmentation of retinal layers, but also gives the pixel wise uncertainty measure of the segmentation output. The generated uncertainty map can be used to identify erroneously segmented image regions which is useful in downstream analysis. We have validated our method on a dataset of 1487 images obtained from 15 subjects (OCT volumes) and compared it against the state-of-the-art segmentation algorithms that does not take uncertainty into account. The proposed uncertainty based segmentation method results in comparable or improved performance, and most importantly is more robust against noise

Angiotensin II stimulates superoxide production by nitric oxide synthase in thick ascending limbs

Angiotensin II (Ang II) causes nitric oxide synthase (NOS) to become a source of superoxide (O2 (-)) via a protein kinase C (PKC)-dependent process in endothelial cells. Ang II stimulates both NO and O2 (-) production in thick ascending limbs. We hypothesized that Ang II causes O2 (-) production by NOS in thick ascending limbs via a PKC-dependent mechanism. NO production was measured in isolated rat thick ascending limbs using DAF-FM, whereas O2 (-) was measured in thick ascending limb suspensions using the lucigenin assay. Consistent stimulation of NO was observed with 1 nmol/L Ang II (P \u3c 0.001; n = 9). This concentration of Ang II-stimulated O2 (-) production by 50% (1.77 ± 0.26 vs. 2.62 ± 0.36 relative lights units (RLU)/s/μg protein; P \u3c 0.04; n = 5). In the presence of the NOS inhibitor L-NAME, Ang II-stimulated O2 (-) decreased from 2.02 ± 0.29 to 1.10 ± 0.11 RLU/s/μg protein (P \u3c 0.01; n = 8). L-arginine alone did not change Ang II-stimulated O2 (-) (2.34 ± 0.22 vs. 2.29 ± 0.29 RLU/s/μg protein; n = 5). In the presence of Ang II plus the PKC α/β1 inhibitor Gö 6976, L-NAME had no effect on O2 (-) production (0.78 ± 0.23 vs. 0.62 ± 0.11 RLU/s/μg protein; n = 7). In the presence of Ang II plus apocynin, a NADPH oxidase inhibitor, L-NAME did not change O2 (-) (0.59 ± 0.04 vs. 0.61 ± ×0.08 RLU/s/μg protein; n = 5). We conclude that: (1) Ang II causes NOS to produce O2 (-) in thick ascending limbs via a PKC- and NADPH oxidase-dependent process; and (2) the effect of Ang II is not due to limited substrate