23 research outputs found
Auto-Mechanization of Open Channel Distribution Systems
Auto-mechanization of surface irrigation refers to the use of mechanical
gates, structures, or other devices and systems that automatically divert
water onto an agricultural field in the proper amount and at the proper time
to satisfy the demands of a growing crop. This enables the farmer to apply
water more efficiently and with a minimum of labor
Computing linkage disequilibrium aware genome embeddings using autoencoders
Motivation
The completion of the genome has paved the way for genome-wide association studies (GWAS), which explained certain proportions of heritability. GWAS are not optimally suited to detect non-linear effects in disease risk, possibly hidden in non-additive interactions (epistasis). Alternative methods for epistasis detection using, e.g. deep neural networks (DNNs) are currently under active development. However, DNNs are constrained by finite computational resources, which can be rapidly depleted due to increasing complexity with the sheer size of the genome. Besides, the curse of dimensionality complicates the task of capturing meaningful genetic patterns for DNNs; therefore necessitates dimensionality reduction.
Results
We propose a method to compress single nucleotide polymorphism (SNP) data, while leveraging the linkage disequilibrium (LD) structure and preserving potential epistasis. This method involves clustering correlated SNPs into haplotype blocks and training per-block autoencoders to learn a compressed representation of the block’s genetic content. We provide an adjustable autoencoder design to accommodate diverse blocks and bypass extensive hyperparameter tuning. We applied this method to genotyping data from Project MinE, and achieved 99% average test reconstruction accuracy—i.e. minimal information loss—while compressing the input to nearly 10% of the original size. We demonstrate that haplotype-block based autoencoders outperform linear Principal Component Analysis (PCA) by approximately 3% chromosome-wide accuracy of reconstructed variants. To the extent of our knowledge, our approach is the first to simultaneously leverage haplotype structure and DNNs for dimensionality reduction of genetic data
Auto-Mechanization of Open Channel Distribution Systems
Auto-mechanization of surface irrigation refers to the use of mechanical
gates, structures, or other devices and systems that automatically divert
water onto an agricultural field in the proper amount and at the proper time
to satisfy the demands of a growing crop. This enables the farmer to apply
water more efficiently and with a minimum of labor