Area Traffic Control and Network Equilibrium

Area traffic control systems play an important role in determining the equilibrium between demand and supply in an urban highway network. The paper describes some of the methods that have been developed for the operation of these systems and derives the level-of-service that would result from a given set of flows. Currently used techniques attempt to optimize network performance assuming a fixed pattern of demands. It is shown, via an example, that control measures can be used to affect the demand pattern in such a way that total network performance is improved. A model for achieving this objective is discussed.Supported in part by the U.S. Army Research Office (Durham) under Contract No. DAHC04-73-C-003

Acceleration Noise as a Measure of Effectiveness in the Operation of Traffic Control System

Acceleration Noise measures the disutility associated with successive decelerations and accelerations in a signalized environment. It provides an indication of the smoothness of traffic flow. As such it constitutes a generalization of the number-of-stops concept and is suitable to replace it as an additive measure-of-effectiveness for designing and evaluating the operation of traffic control systems. This report develops models for calculating the acceleration noise incurred by a platoon of vehicles travelling along a signal-controlled traffic link. Several flow patterns are analyzed: discrete arrivals, uniformcontinuous arrivals and variable-continuous arrivals. A computer program and test results are described. The models can be easily extended for use in signal- controlled networks.Research supported by KLD Associates, Inc., in connection with Department of Transportation Contract FH-11-7924

Webster’s Delay Formula – revisited

The equations developed byWebster in his famous 1958 report[10] are still the basis of traffic signal planning today. They are being used in handbooks like the HCM and similar instruments world-wide. However, the handbook approach typically works with approximations to the original equations which have stood the test of time, but may nevertheless not be the best to be done today. This work analyzes Webster’s approach and advocates a more modern use of it which utilizes the tremendous advances in computer hardware and software. This is being done by comparing approximations to exact solutions, and by a comparison between various models and Webster’s equations itself. It is shown that there can be significant differences in the calculation of optimal cycle times and consequent delay times

Modeling and Optimization for Transportation Systems Planning and Operations

In this paper, we focus on a number of applications of network optimization techniques to transportation systems analysis. In particular, network analysis problems, network design problems, and network management problems are discussed in some detail. The intent is to survey important application areas.*To be presented at the International Symposium on Large Engineering Systems, University of Manitoba, Winnipeg, Manitoba, Canada, August 9-12, 197

Experimental and theoretical evidence for molecular forces driving surface segregation in photonic colloidal assemblies

Surface segregation in binary colloidal mixtures offers a simple way to control both surface and bulk properties without affecting their bulk composition. Here, we combine experiments and coarse-grained molecular dynamics (CG-MD) simulations to delineate the effects of particle chemistry and size on surface segregation in photonic colloidal assemblies from binary mixtures of melanin and silica particles of size ratio (Dlarge/Dsmall) ranging from 1.0 to similar to 2.2. We find that melanin and/or smaller particles segregate at the surface of micrometer-sized colloidal assemblies (supraballs) prepared by an emulsion process. Conversely, no such surface segregation occurs in films prepared by evaporative assembly. CG-MD simulations explain the experimental observations by showing that particles with the larger contact angle (melanin) are enriched at the supraball surface regardless of the relative strength of particle-interface interactions, a result with implications for the broad understanding and design of colloidal particle assemblies

Surficial Redistribution of Fallout 131iodine in a Small Temperate Catchment

Isotopes of iodine play significant environmental roles, including a limiting micronutrient (127I), an acute radiotoxin (131I), and a geochemical tracer (129I). But the cycling of iodine through terrestrial ecosystems is poorly understood, due to its complex environmental chemistry and low natural abundance. To better understand iodine transport and fate in a terrestrial ecosystem, we traced fallout 131iodine throughout a small temperate catchment following contamination by the 11 March 2011 failure of the Fukushima Daiichi nuclear power facility. We find that radioiodine fallout is actively and efficiently scavenged by the soil system, where it is continuously focused to surface soils over a period of weeks following deposition. Mobilization of historic (pre-Fukushima) 137cesium observed concurrently in these soils suggests that the focusing of iodine to surface soils may be biologically mediated. Atmospherically deposited iodine is subsequently redistributed from the soil system via fluvial processes in a manner analogous to that of the particle-reactive tracer 7beryllium, a consequence of the radionuclides’ shared sorption affinity for fine, particulate organic matter. These processes of surficial redistribution create iodine hotspots in the terrestrial environment where fine, particulate organic matter accumulates, and in this manner regulate the delivery of iodine nutrients and toxins alike from small catchments to larger river systems, lakes and estuaries

Strategic Planning for Connected and Automated Vehicles In Massachusetts

ISA#92312Connected and Automated Vehicle (CAV) technologies are evolving at a fast pace, and new developments are occurring on a daily basis. These technologies have potential to significantly change transportation and travel, to make them safer, more accessible, and more efficient than they are today. There are many issues that will have to be investigated, such as the pace and extent to which CAV technologies become pervasive, the socioeconomic impacts of CAVs, their implication on privacy and security; to what extent will these technologies replace human drivers, and the legal and regulatory responsibilities for the safe operation of CAVs. State departments of transportation (DOTs) will need to plan to prepare for and accommodate CAV technologies. The purpose of this study is to provide baseline information pertaining to strategic planning for CAV technologies in Massachusetts. This information may be used to assist the Massachusetts Department of Transportation (MassDOT) to develop a strategic plan to accommodate the deployment of such technologies and for related infrastructure investment decisions

AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data.

Detecting multiplets in single nucleus (sn)ATAC-seq data is challenging due to data sparsity and limited dynamic range. AMULET (ATAC-seq MULtiplet Estimation Tool) enumerates regions with greater than two uniquely aligned reads across the genome to effectively detect multiplets. We evaluate the method by generating snATAC-seq data in the human blood and pancreatic islet samples. AMULET has high precision, estimated via donor-based multiplexing, and high recall, estimated via simulated multiplets, compared to alternatives and identifies multiplets most effectively when a certain read depth of 25K median valid reads per nucleus is achieved

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide

BACKGROUND: For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission. In the absence of vaccines, topical microbicides, expected to block virus transmission, offer hope for controlling the pandemic. Antiretroviral chemotherapeutics have decreased AIDS mortality in industrialized countries, but only minimally in developing countries. To prevent an analogous dichotomy, microbicides should be: acceptable; accessible; affordable; and accelerative in transition from development to marketing. Already marketed pharmaceutical excipients or foods, with established safety records and adequate anti-HIV-1 activity, may provide this option. METHODS: Fruit juices were screened for inhibitory activity against HIV-1 IIIB using CD4 and CXCR4 as cell receptors. The best juice was tested for inhibition of: (1) infection by HIV-1 BaL, utilizing CCR5 as the cellular coreceptor; and (2) binding of gp120 IIIB and gp120 BaL, respectively, to CXCR4 and CCR5. To remove most colored juice components, the adsorption of the effective ingredient(s) to dispersible excipients and other foods was investigated. A selected complex was assayed for inhibition of infection by primary HIV-1 isolates. RESULTS: HIV-1 entry inhibitors from pomegranate juice adsorb onto corn starch. The resulting complex blocks virus binding to CD4 and CXCR4/CCR5 and inhibits infection by primary virus clades A to G and group O. CONCLUSION: These results suggest the possibility of producing an anti-HIV-1 microbicide from inexpensive, widely available sources, whose safety has been established throughout centuries, provided that its quality is adequately standardized and monitored

Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles

BACKGROUND: Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV-1 and to block the coreceptor binding site on the virus envelope glycoprotein gp120. It did not interfere with virus binding to CD4. Since CD4 is the primary cellular receptor for HIV-1, it was of interest to study CAP binding to HIV-1 complexes with soluble CD4 (sCD4) and its consequences, including changes in the conformation of the envelope glycoprotein gp41 within virus particles. METHODS: Enzyme-linked immunosorbent assays (ELISA) were used to study CAP binding to HIV-1-sCD4 complexes and to detect gp41 six-helix bundles accessible on virus particles using antibodies specific for the α-helical core domain of gp41. RESULTS: 1) Pretreatment of HIV-1 with sCD4 augments subsequent binding of CAP; 2) there is synergism between CAP and sCD4 for inhibition of HIV-1 infection; 3) treatment of HIV-1 with CAP induced the formation of gp41 six-helix bundles. CONCLUSIONS: CAP and sCD4 bind to distinct sites on HIV-1 IIIB and BaL virions and their simultaneous binding has profound effects on virus structure and infectivity. The formation of gp41 six-helical bundles, induced by CAP, is known to render the virus incompetent for fusion with target cells thus preventing infection