Eliminating grammatical function assignment from hierarchical models of speech production: Evidence from the conceptual accessibility of referents

ABSTRACTThe assignment of grammatical functions has been a key feature of hierarchical (serial) models of speech production since their inception in the 1970s. This article argues that grammatical function assignment is neither sufficient nor necessary in such models. It reports a study of the effects of the conceptual accessibility of referents on the selection of English dative syntactic frames in production and shows that the effects relate to linear precedence rather than grammatical function assignment. A secondary topic addressed in the same study is whether second language speakers of English have difficulty integrating syntactic knowledge where it interfaces with conceptual accessibility in speech production. Findings suggest that advanced proficiency speakers do not and are qualitatively similar to native speakers. The implications of this for the interface hypothesis about second language acquisition are discussed.</jats:p

Globalization, the ambivalence of European integration and the possibilities for a post-disciplinary EU studies

Using the work of Manuel Castells as a starting point, this article explores the ambivalent relationship between globalization and European integration and the variety of ways in which the mainstream political science of the EU has attempted to deal with this issue. The analysis here suggests that various 'mainstreaming' disciplinary norms induce types of work that fail to address fully the somewhat paradoxical and counter-intuitive range of possible relationships between globalization and European integration. The article explores critically four possible analytical ways out of this paradox—abandonment of the concept of globalization, the development of definition precision in globalization studies, the reorientation of work to focus on globalization as discourse, and inter- and post-disciplinarity. The argument suggests that orthodox discussions of the relationship require a notion of social geography that sits at odds with much of the literature on globalization and while greater dialogue between disciplines is to be welcomed, a series of profound epistemological questions need to be confronted if studies of the interplay between global and social process are to be liberated from their disciplinary chains

Household economic hardship as a moderator of the associations between maternal spanking and child externalizing behavior problems.

Background: Spanking is associated with detrimental outcomes for young children. Research shows that spanking is more commonly used in low-income households. Objective: To examine whether economic hardship, measured by household income-to-poverty ratio at the time of the child’s birth, moderated the longitudinal associations between maternal spanking and child externalizing behavior problems during the first nine years of childhood. Participants and setting: Mother-child pairs (N = 4,149) from a cohort study of urban families in 20 US cities. Methods: Cross-lagged path models examined associations between maternal spanking and ex- ternalizing behavior when children were between the ages of 1 and 9. Multigroup analyses ex- amined whether income-to-poverty ratio moderated these associations. Results: Bivariate analyses showed that income-to-poverty ratio was associated with child ex- ternalizing behavior problems at each time point; income-to-poverty ratio was associated with maternal spanking at age 3 only. Longitudinal path model results indicated that, for low- and middle-income groups, maternal spanking at each age had significant associations with child externalizing behavior at each subsequent age. For the high-income group, maternal spanking at age 1 and age 3 had significant associations with child externalizing behavior at each subsequent age; however, spanking at age 5 was not associated with child externalizing behavior at age 9. Conclusions: Spanking is disadvantageous for children at all income levels, with more persistent effects in low- and middle-income families. For higher-income families, the associations of ma- ternal spanking with child externalizing behavior problems may be attenuated as child age in- creases. Regardless of income level, parents should be advised against spanking.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163755/1/2020-Lee-Householdeconomichardship.pdfDescription of 2020-Lee-Householdeconomichardship.pdf : Main articl

Attachment style and the association of spanking and child externalizing behavior

OBJECTIVE: To examine whether the longitudinal associations between maternal spanking and child externalizing behavior are moderated by attachment style. METHODS: This study used data from the Fragile Families and Child Wellbeing Study (n = 2211), a large cohort sample of low-income urban families. Multiple-group autoregressive cross-lagged models examined the associations between maternal spanking and child externalizing behavior when children were ages 1, 3, and 5. Moderation by attachment style was examined using structural invariance testing. RESULTS: For children with an insecure mother-child attach- ment style, spanking at age 1 was associated with externalizing behavior at age 3. However, for children with a secure mother- child attachment style, the association between maternal spank- ing at age 1 and child externalizing behavior at age 3 was absent. Attachment style did not moderate the association between maternal spanking at age 3 and externalizing behavior at age 5, suggesting that spanking at age 3 is associated with deleterious outcomes at age 5, regardless of attachment style. CONCLUSIONS: Results suggest that even in the context of a secure attachment style, spanking is associated with adverse outcomes in early childhood. Findings support the American Academy of Pediatrics 2018 policy statement, which encour- ages parents to avoid spanking when disciplining children. Results suggest that children, regardless of attachment style, may benefit from policies and services that promote non-vio- lent forms of discipline.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163754/1/2020-Ward-Attachmentstyleandtheassociation.pdfDescription of 2020-Ward-Attachmentstyleandtheassociation.pdf : Main articl

Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and COL5A2 frequently occur in Chiari Malformation Type 1

Seqüenciació de gens; Genòmica; Imatges per ressonància magnèticaSecuenciación de genes; Genómica; Imágenes por resonancia magnéticaGene sequencing; Genomics; Magnetic resonance imagingChiari Malformation Type 1 (CM-1) is characterized by herniation of the cerebellar tonsils below the foramen magnum and the presence of headaches and other neurologic symptoms. Cranial bone constriction is suspected to be the most common biologic mechanism leading to CM-1. However, other mechanisms may also contribute, particularly in the presence of connective tissue disorders (CTDs), such as Ehlers Danlos Syndrome (EDS). Accumulating data suggest CM-1 with connective tissue disorders (CTD+) may have a different patho-mechanism and different genetic risk factors than CM-1 without CTDs (CTD-). To identify CM-1 genetic risk variants, we performed whole exome sequencing on a single large, multiplex family from Spain and targeted sequencing on a cohort of 186 unrelated adult, Caucasian females with CM-1. Targeted sequencing captured the coding regions of 21 CM-1 and EDS candidate genes, including two genes identified in the Spanish family. Using gene burden analysis, we compared the frequency of rare, functional variants detected in CM-1 cases versus publically available ethnically-matched controls from gnomAD. A secondary analysis compared the presence of rare variants in these genes between CTD+ and CTD- CM-1 cases. In the Spanish family, rare variants co-segregated with CM-1 in COL6A5, ADGRB3 and DST. A variant in COL7A1 was present in affected and unaffected family members. In the targeted sequencing analysis, rare variants in six genes (COL7A1, COL5A2, COL6A5, COL1A2, VEGFB, FLT1) were significantly more frequent in CM-1 cases compared to public controls. In total, 47% of CM-1 cases presented with rare variants in at least one of the four significant collagen genes and 10% of cases harbored variants in multiple significant collagen genes. Moreover, 26% of CM-1 cases presented with rare variants in the COL6A5 gene. We also identified two genes (COL7A1, COL3A1) for which the burden of rare variants differed significantly between CTD+ and CTD- CM-1 cases. A higher percentage of CTD+ patients had variants in COL7A1 compared to CTD+ patients, while CTD+ patients had fewer rare variants in COL3A1 than did CTD- patients. In summary, rare variants in several collagen genes are particularly frequent in CM-1 cases and those in COL6A5 co-segregated with CM-1 in a Spanish multiplex family. COL6A5 has been previously associated with musculoskeletal phenotypes, but this is the first association with CM-1. Our findings underscore the contribution of rare genetic variants in collagen genes to CM-1, and suggest that CM-1 in the presence and absence of CTD symptoms is driven by different genes.This work was supported by a grant from Conquer Chiari to AAK. Collection of the Chiari1000 study participants utilized in this study was supported by a grant from Conquer Chiari to FL at University of Akron. Collection of the Duke study participants utilized in this study was supported by a grant from the National Institutes of Health (NS063273). A.U. was the recipient of a Postdoctoral Fellowship from Fundación Ramón Areces (Spain). RL is the Executive Director of Conquer Chiari which provided some of the funding for this work. For the manuscript, he assisted with revising and editing the manuscript. The funders did have a role in study design, but had no role in data collection and analysis, decision to publish, or preparation of the manuscript

Frustration-Induced Two Dimensional Quantum Disordered Phase in Piperazinium Hexachlorodicuprate

Piperazinium Hexachlorodicuprate (PHCC) is shown to be a frustrated quasi-two-dimensional quantum Heisenberg antiferromagnet with a gapped spectrum. Zero-field inelastic neutron scattering and susceptibility and specific heat measurements as a function of applied magnetic field are presented. At T = 1.5 K, the magnetic excitation spectrum is dominated by a single propagating mode with a gap, Delta = 1 meV, and bandwidth of approximately 1.8 meV in the (h0l) plane. The mode has no dispersion along the b* direction indicating that neighboring a-c planes of the triclinic structure are magnetically decoupled. The heat capacity shows a reduction of the gap as a function of applied magnetic field in agreement with a singlet-triplet excitation spectrum. A field-induced ordered phase is observed in heat capacity and magnetic susceptibility measurements for magnetic fields greater than H_c1 approximately equal to 7.5 Tesla. Analysis of the neutron scattering data reveals the important exchange interactions and indicates that some of these are highly frustrated.Comment: 13 pages with 14 figures, 7 pages of text, 6 pages of figures. Submitted to Phys. Rev. B 4/7/2001. email comments to [email protected] or [email protected]

Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure

Extracellular heat-shock protein 72 (eHsp72) concentration increases during exercise-heat stress when conditions elicit physiological strain. Differences in severity of environmental and exercise stimuli have elicited varied response to stress. The present study aimed to quantify the extent of increased eHsp72 with increased exogenous heat stress, and determine related endogenous markers of strain in an exercise-heat model. Ten males cycled for 90 min at 50% O2peak in three conditions (TEMP, 20°C/63% RH; HOT, 30.2°C/51%RH; VHOT, 40.0°C/37%RH). Plasma was analysed for eHsp72 pre, immediately post and 24-h post each trial utilising a commercially available ELISA. Increased eHsp72 concentration was observed post VHOT trial (+172.4%) (P<0.05), but not TEMP (-1.9%) or HOT (+25.7%) conditions. eHsp72 returned to baseline values within 24hrs in all conditions. Changes were observed in rectal temperature (Trec), rate of Trec increase, area under the curve for Trec of 38.5°C and 39.0°C, duration Trec ≥ 38.5°C and ≥ 39.0°C, and change in muscle temperature, between VHOT, and TEMP and HOT, but not between TEMP and HOT. Each condition also elicited significantly increasing physiological strain, described by sweat rate, heart rate, physiological strain index, rating of perceived exertion and thermal sensation. Stepwise multiple regression reported rate of Trec increase and change in Trec to be predictors of increased eHsp72 concentration. Data suggests eHsp72 concentration increases once systemic temperature and sympathetic activity exceeds a minimum endogenous criteria elicited during VHOT conditions and is likely to be modulated by large, rapid changes in core temperature

Deep Extragalactic VLBI-Optical Survey (DEVOS): I. Pilot MERLIN and VLBI observations

We present the results of the pilot observations of the Deep Extragalactic VLBI-Optical Survey (DEVOS). Our ultimate aim is to collect information on compact structures in a large sample of extragalactic radio sources (~10000 objects) up to two orders of magnitude fainter than those studied in typical imaging Very Long Baseline Interferometry (VLBI) surveys up until now. This would lead to an unprecedented data base for various astrophysical, astrometric and cosmological studies. The first global VLBI observations of the DEVOS programme were successfully conducted in May 2002. We selected sources without any spectral criterion from the Very Large Array (VLA) Faint Images of the Radio Sky at Twenty-centimeters (FIRST) catalogue, that are also detected with the Multi-Element Radio Linked Interferometer Network (MERLIN). The DEVOS pilot sample sources are in the area of the sky that is covered by the Sloan Digital Sky Survey (SDSS). We describe the sample selection and present high resolution 5-GHz radio images of the sources. Based on the results of this pilot study, we estimate the outcome of and the resources needed for a full-scale DEVOS project.Comment: 19 pages, 8 figures, accepted by A&