The Brazilian Sanitary Reform’s influence in the construction of a national bioethics

Este artigo de revisão reconstrói em linhas gerais o caminho percorrido pela bioética brasileira na formulação de linhas autóctones de estudo e pesquisa a partir da relação entre essas linhas e o processo histórico e social que consolidou a Reforma Sanitária no país. Foram selecionados os trabalhos e perspectivas teóricas que se propõem a atuar no mesmo âmbito, a dimensão social; que se referem a grupos ou segmentos particularmente vulneráveis; que questionam as relações de poder a partir da identificação das desigualdades sociais, bem como as voltadas para os mesmo parâmetros norteadores, os tratados de direitos humanos, ou ainda aquelas que incluem no rol de sua temática a discussão sobre a qualidade de vida. A apresentação destas distintas visões da bioética brasileira está circunscrita aos pontos tangenciais específicos acima relacionados e orientada cronologicamente a partir da criação do termo “bioética” nos meios acadêmicos estadunidenses. _______________________________________________________________________________________ ABSTRACTThis revision article remakes in general guidelines the path to the Brazilian Bioethics in the planning of research and education autochthones lines from the relations between these lines and the social and historical process that consolidated the Brazilian Sanitary Reform. The works and theoretical perspectives selected have the proposal to act in the some scope, the social dimension; that relate to groups or particularly vulnerable segments that question the power relationship from the identification of the social inequalities as well as to the ones focused in the same orienting parameters, the Human Rights treaties; or the ones that included in its themathical rol the discussion about quality of life. The presentation of these distinct points of views of the Brazilian Bioethics are circumscribed at the tangential specifically relationed above and chronologically orientated from the creation of the “Bioethics” term in the North American academic environment

A simple blood tests, such as complete blood count, can predict calcification grade of Abdominal Aortic Aneurysm.

Objective. The pathogenesis of abdominal aortic aneurysm (AAA) is complex and different factors, including calcification, are linked to increased complications. This study was conducted in order to verify if classical risk factors for AAA and cell blood count parameter could help in the identification of calcification progression of the aneurysm. Design. Risk factors were collected and cell blood count was performed in patients with AAA and patients were analyzed for the presence of aorta calcification using CT angiography. Results. We found no association of calcification grade with risk factors for AAA but we found a strong association between MCV, MCH, and calcification grade. Instead, no association was found with the other parameter that we analyzed. Conclusions. In this study, we demonstrate that biomarkers such as MCV and MCH could have potential important information about AAA calcification progression and could be useful to discriminate between those patients that should undergo a rapid imaging, thus allowing prompt initiation of treatment of suspicious patients that do not need imaging repetition

Ensaio Nacional de aveias forrageiras 2009 - análise conjunta.

Com objetivo de avaliar a capacidade produtiva de forragem de genótipos de aveias brancas e pretas, foram conduzidos experimentos em oito locais do Brasil (Cruz Alta, Passo Fundo e Três de Maio no Rio Grande do Sul; Lages e Canoinhas em Santa Catarina; Londrina e Ponta Grossa no Paraná e São Carlos em São Paulo)

Efeito de épocas de semeadura sobre o desempenho de genótipos de canola em Três de Maio, RS.

bitstream/CNPT-2010/40356/1/p-ci17.pd

Human iPSC-Derived 3D Hepatic Organoids in a Miniaturized Dynamic Culture System

The process of identifying and approving a new drug is a time-consuming and expensive procedure. One of the biggest issues to overcome is the risk of hepatotoxicity, which is one of the main reasons for drug withdrawal from the market. While animal models are the gold standard in preclinical drug testing, the translation of results into therapeutic intervention is often ambiguous due to interspecies differences in hepatic metabolism. The discovery of human induced pluripotent stem cells (hiPSCs) and their derivatives has opened new possibilities for drug testing. We used mesenchymal stem cells and hepatocytes both derived from hiPSCs, together with endothelial cells, to miniaturize the process of generating hepatic organoids. These organoids were then cultivated in vitro using both static and dynamic cultures. Additionally, we tested spheroids solely composed by induced hepatocytes. By miniaturizing the system, we demonstrated the possibility of maintaining the organoids, but not the spheroids, in culture for up to 1 week. This timeframe may be sufficient to carry out a hypothetical pharmacological test or screening. In conclusion, we propose that the hiPSCderived liver organoid model could complement or, in the near future, replace the pharmacological and toxicological tests conducted on animals