Understanding early inhibitory development : distinguishing two ways that children use inhibitory control

Inhibitory control is the capacity to suppress inappropriate responses. It is regarded as a unitary construct, central to executive function and effortful control, as well as many aspects of child development. There are, nevertheless, significant gaps in our understanding of inhibition’s early development, and several robust findings that remain hard to explain. These findings are outlined, and a new perspective on inhibitory control presented, which explains them by distinguishing between two ways that inhibitory control is used. According to the ‘strength/endurance account’, responses which are highly prepotent tax inhibitory strength; whereas, those which remain active for a long time tax inhibitory endurance. The review considers when and how these aspects of inhibition mature, before discussing their impact on development

Structural study of acidic metallocavitands and characterization of their interactions with Lewis bases

We report the synthesis and characterization of tantalum−boronate trimetallic clusters of the general formula {[Cp*Ta]3(μ2-RB(O)2)3(μ2-OH)(μ2-O)2(μ3-OH)} (R = i-Bu (Ta3-iBu), C6H5 (Ta3-Ph), 2,5-(CH3)2(C6H3) (Ta3-2,5Me), 3,5-(CH3)2(C6H3) (Ta3-3,5Me), and 3,5-(CF3)2(C6H3) (Ta3-3,5CF3)). Three of these complexes feature a Lewis acid type cavity allowing for substrate binding in both the solid and the liquid state using a unique electrostatic interaction and a hydrogen bond. We also report the synthesis of {[Cp*Ta]2(μ2-MesB(O)2)2[MesB(OH)(O)]2(μ2-OH)2} (Mes = 2,4,6-(CH3)3C6H2 (Ta2-Mes)). All complexes have been characterized by NMR and X-ray diffraction studies, and the steric and electronic effects on the boronate ligands have been investigated. The physical properties of the interaction between the tantalum−boronate clusters and tetrahydrofuran and acetone have been studied by thermogravimetric analysis, FT-IR, and Density Functional Theory calculations to characterize the molecular interactions in the resulting adducts

Characterizing the heterogeneity of disruptions in the resolution of trauma among women exposed to childhood maltreatment

Abstract The previously observed heterogeneity in developmental and intergenerational trajectories of childhood trauma may root from interindividual differences in the way trauma-exposed individuals have resolved these experiences. The current study explored whether distinctive patterns of impaired mentalization in relation to trauma could be identified in a sample of 825 pregnant women who experienced childhood maltreatment and whether these heterogeneous patterns were marked by significant differences in internalized and externalized problems during pregnancy, intimate partner violence, personality dysfunctions, and antenatal attachment. A latent profile analysis applied to the seven subscales of the Failure to Mentalize Trauma Questionnaire unraveled interindividual variability in mentalizing impairments among pregnant women exposed to childhood maltreatment by identifying five distinctive types of psychological responses to trauma, each being associated in cross-sectional analyses with a specific set of symptoms and dysfunctions. Overall, the study highlights the need for tailored interventions based on the individuals’ specific impairments in mentalizing trauma and calls for future developmental research exploring the longitudinal correlates of the five documented profiles of trauma processing

Synthesis and characterization of tantalum(V) boronate clusters : multifunctional Lewis acid cages for binding guests

Open and shut cases: Tantalum(V) boronate clusters [(Cp*Ta)3(μ2‐η2‐RBO2)3(μ2‐O)2(μ2‐OH)(μ3‐OH)] (Cp*=η5‐C5Me5; 1: R=Ph, 2: R=iBu) with Lewis acidic cavities were prepared. Whereas the cavity of 2 is blocked by the iBu groups, that of 1 is open and can bind Lewis basic guests such as ketones (see picture) by interaction with one boronate and one μ3‐OH ligand

On the interaction of acetone with electrophilic metallocavitands having extended cavities

We report the synthesis and characterization of tantalum–boronate trimetallic clusters of general formula {[Cp*Ta]3(μ2-RB(O)2)3(μ2-OH)(μ2-O)2(μ3-OH)} (R= 4-(C6H5)(C6H4) (Ta3-4Ph), 4-(C6H5O)(C6H4) (Ta3-4OPh), 4-(C7H7O)(C6H4) (Ta3-4OBn), 4-(C8H5)(C6H4) (Ta3-4PhEt), and 4-(C12H7)(C6H4) (Ta3-4Napht)). All complexes have been characterized by NMR spectroscopy and X-ray diffraction. The trimetallic species feature a large Lewis acid type cavity allowing for substrate binding in both the solid and the liquid state using a unique electrostatic interaction and a hydrogen bond. ΔH° and ΔS° values for association of acetone with the complexes vary between −2.0 and −4.1 kcal·mol–1 and −3 and 2 cal·mol–1·K–1, respectively, showing weaker binding than smaller cavitands of the same type. The barrier for acetone exchange at equilibrium is similar for all complexes, and ΔH‡ values vary between 8.2 and 11.4 kcal·mol–1

Development and validation of a self-report measure assessing failures in the mentalization of trauma and adverse relationships

Background: The way people process trauma and adverse relationships may be more predictive of subsequent adaptation than trauma exposure in itself. However, there is currently no self-report instrument assessing failures in the mentalization of trauma and adverse relationships. Objective: We developed the Failure to Mentalize Trauma Questionnaire (FMTQ) and evaluated its psychometric properties. The FMTQ is a 29-item self-report instrument designed to assess different indications of failures in the mentalization of trauma and adverse relationships. Participants and setting A total of 975 participants (84 % women; 37 % exposed to child maltreatment) were recruited in the course of larger research protocols on parenting. Methods: Participants completed the FMTQ and measures of childhood maltreatment, psychopathology (post-traumatic stress symptoms, dissociative symptoms, level of personality dysfunction), general mentalization and intimate partner violence. Results: Exploratory factor analysis, supported by a confirmatory factor analysis, identified seven factors with good internal consistency that corresponded to different types of failures in the mentalization of trauma and adverse relationships and that loaded on a general factor. A dose-effect association was observed between the severity of childhood maltreatment, and the severity of failures in the mentalization of trauma and adverse relationships (rs = .49, p < .01). The FMTQ total score explained a significant proportion of variance in psychopathology and intimate partner violence, both in participants with histories of childhood maltreatment and participants without childhood maltreatment. Conclusion: The FMTQ is a promising, concise and efficient measure of failures in the mentalization of trauma and adverse relationships that may facilitate clinical screening and research with adults who experienced trauma

A deeper look at the association between childhood maltreatment and reflective functioning

Childhood maltreatment is theorized as impeding the development of reflective functioning (RF; ability to perceive and interpret oneself and others in terms of mental states). However, previous research typically failed to support this association or yielded small sized and mixed associations. This study aims to provide a deeper look at the association between childhood maltreatment and RF by characterizing two non-mentalizing categories. One-hundred-and-sixteen pregnant women (mean age = 27.62, SD = 4.52) from the community (48.3% with a university degree, 96.5% in a relationship with the other parent) retrospectively reported on childhood abuse and neglect using the Childhood Trauma Questionnaire. They also participated in the Adult Attachment Interview subsequently coded using the Reflective Functioning Scale. Participants with poor to low RF were allocated to one of two groups (disavowal-distancing or distorted-inconsistent) using indicators provided in the RF Scale. No association was found between childhood maltreatment and overall RF when controlling for education level. A multinomial logistic regression revealed that childhood maltreatment was strongly predictive of a disrupted, over-analytical and inconsistent reflection about mental states but not of a tendency to discourse little about mental states. This tendency was rather only predicted by education level. Findings suggest that childhood maltreatment would lead to specific impairments in RF and that not considering how individuals fail to mentalize about attachment relationships may mask strong associations between RF and its determinants and correlates, including childhood maltreatment

Cumulative childhood trauma and complex psychiatric symptoms in pregnant women and expecting men

Background: Women and men having been exposed to childhood trauma would be at high risk of various mental health symptoms while awaiting a child. This study aimed to evaluate the association between cumulative childhood trauma and the accumulation of symptoms belonging to different psychiatric problems in pregnant women and expecting men. Methods: We first examined prevalence rates of childhood trauma across our samples of 2853 pregnant women and 561 expecting men from the community. Second, we evaluated the association between cumulative childhood trauma and symptom complexity (i.e., the simultaneous presentation of symptoms belonging to multiple psychiatric problems) using subsamples of 1779 pregnant women and 118 expecting men. Participants completed self-reported measures of trauma (Childhood Trauma Questionnaire) and psychiatric symptoms (PTSD Checklist for DSM-5; Kessler Psychological Distress Scale; State-Trait Anger Expression Inventory-2; Self and Interpersonal Functioning Scale). Results: Trauma was more frequent in pregnant women than in expecting men and in participants reporting sociodemographic risk factors than in those not reporting any. A dose-response relationship was observed between the number of different traumas reported by pregnant women and expecting men and the complexity of their psychiatric symptoms, even when controlling for the variance explained by other risk factors. Women having been exposed to cumulative childhood trauma were 4.95 times more at risk of presenting comorbid psychiatric problems during pregnancy than non-exposed women. Conclusions: Childhood trauma is frequent in the general population of pregnant women and expecting men and is associated with symptom complexity during the antenatal period. These findings call for delivering and evaluating innovative trauma-informed antenatal programs to support mental health and adaptation to parenthood in adults having been exposed to childhood trauma. © 2021, The Author(s)

Paucity of intervention research in childhood maltreatment contrasts with the long known relation with mental health disorders: is trauma research translational enough?

The damaging consequences of child abuse and neglect for child development and psychiatric disorders have been known for decades. However, there would be a relative paucity of translational research on childhood maltreatment in comparison to the numerous correlational studies in the field. To assess the extent to which previous research on childhood maltreatment addressed intervention, we reviewed all articles on child abuse and neglect published in 2016 and evaluated the main objective of each study. References were identified through PsycINFO (ƙ = 2139) and Medline (ƙ = 2955). Of the 3792 studies retained after removal of overlapping references, 1157 met inclusion criteria. The main objective of each study was coded according to one of the following categories: Consequences, Mechanisms, Intervention, Prevention and Others. The review showed that half of the studies (ƙ = 572; 50%) described the damaging consequences of child abuse and neglect. A mere 19% of the studies (ƙ = 225) aimed to identify mediators or moderators of the association between childhood maltreatment and outcome. Only 6% (ƙ = 66) of studies reported on treatments and 2% (ƙ = 29) on preventive interventions. The remaining articles (23%, ƙ = 265) focused on other topics, such as the assessment of childhood trauma (ƙ = 33), epidemiology (ƙ = 118) and legal or organizational issues (ƙ = 114). Our results revealed an unquestionable paucity of research published on interventions and a relatively scarce number of mechanistic studies that nonetheless may provide meaningful practical orientations for clinical practice and future research

Maternal childhood abuse and neglect predicts offspring development in early childhood: the roles of reflective functioning and child sex

Background: Recent evidence suggests that offspring of mothers having been exposed to childhood abuse and neglect (CA&N) are at increased risk of developmental problems and that boys are more affected by maternal CA&N than girls. Since impairments in reflective functioning (RF) have been associated with maternal CA&N and offspring development, RF could represent a key mechanism in these intergenerational risk trajectories. Objective: This study evaluated mediating (RF) and moderating (child sex) mechanisms in the association between maternal CA&N and child development. Participants and setting: In a longitudinal setting, 111 mothers completed measures during pregnancy and between 11 and 36 months postpartum. Methods: CA&N and impairments in RF were assessed during pregnancy and offspring development was measured during the longitudinal follow-up using the Ages and Stages Questionnaires (ASQ-3). Child development was operationalized in two ways: using the global score at the ASQ-3 and using a dichotomous score of accumulation of delays across domains of development. Results: Structural equation modeling indicated that RF mediated the association between maternal CA&N and offspring development. Child sex moderated the association between CA&N and the clustering of developmental problems (Wald = 5.88, p = 0.02), with boys being particularly likely to accumulate developmental delays when their mother experienced CA&N (RR = 2.62). Accumulation of developmental problems was associated with impairments in maternal RF in girls and with maternal exposure to CA&N in boys. Conclusions: Results provide novel insights on the role of mentalization and child sex in the association between maternal CA&N and child development. © 2021 The Author