Technology for developing the professional competence of physical education teachers in architecture and construction university

The objective of this paper is to investigate the possibility of forming the professional competence of physical education teachers in a university of architecture and engineering. At the beginning of the experiment the baseline level of teachers' professional competence was determined in order to form the control and experimental groups among them. In the control group the formation of competence of teachers was carried out by taking professional development courses according to the «standard» program, according to which the participants were given lectures, seminars on various modules of the program, having to complete a course with a final qualifying paper on a selected topic. Teachers in the experimental group were trained according to the professional development programme, taking into account the developed model of competence formation. At the end of the training the previously studied indicators were tested in both groups and the data obtained was then compared. As a result, it was found that the professional competence level of teachers in the experimental group increased significantly compared to this in the control group. Thus, it showed that to be able to form teachers' professional competence «standard» professional development programmes currently implemented by Kazan State University of Architecture and Engineering are not enough. For effective formation of competence it is necessary to have a special technology of teachers' training, which is implemented in the developed pedagogical model of formation of teachers' professional competence

Current trends in the construction of sports infrastructure facilities, taking into account the direction of development of the international Olympic movement

The study aims to assess current trends in the construction of sports infrastructure, considering the development and improvement vectors of the Olympic movement. Materials and methods. The study utilizes literature analysis, statistical methods, expert assessment method and legal analysis. Results. Trends in the development of sports infrastructure facilities for the Olympic Games have been identified and substantiated. The currentdifficulties regarding organizing and holding of the Olympic Games and the uprising contradictions in the activities of international sports organizations have been structured. Analysis of trends in the development of the Olympic movement in the XXI century and recent decisions of the International Olympic Committee revealed particular problems in the organization of the Games. The proposed new model of the modern Olympic Games allowing to overcome problems and contradictions of the Olympic movement is described. Conclusion. The modern stage of development of the Olympic movement is characterized by a number of contradictions and problems that need to be solved: gigantism of the Olympic Games, subjectivity of refereeing at sports competitions, safety at sports events, etc. The proposed model of the organization of the Olympic Games in the form of long-term competitions during the Olympic Year may help to overcome existing contradictions

Supramolecular peptide nanofiber morphology affects mechanotransduction of stem cells

Chirality and morphology are essential factors for protein function and interactions with other biomacromolecules. Extracellular matrix (ECM) proteins are also similar to other proteins in this sense; however, the complexity of the natural ECM makes it difficult to study these factors at the cellular level. The synthetic peptide nanomaterials harbor great promise in mimicking specific ECM molecules as model systems. In this work, we demonstrate that mechanosensory responses of stem cells are directly regulated by the chirality and morphology of ECM-mimetic peptide nanofibers with strictly controlled characteristics. Structural signals presented on l-amino acid containing cylindrical nanofibers (l-VV) favored the formation of integrin β1-based focal adhesion complexes, which increased the osteogenic potential of stem cells through the activation of nuclear YAP. On the other hand, twisted ribbon-like nanofibers (l-FF and d-FF) guided the cells into round shapes and decreased the formation of focal adhesion complexes, which resulted in the confinement of YAP proteins in the cytosol and a corresponding decrease in osteogenic potential. Interestingly, the d-form of twisted-ribbon like nanofibers (d-FF) increased the chondrogenic potential of stem cells more than their l-form (l-FF). Our results provide new insights into the importance and relevance of morphology and chirality of nanomaterials in their interactions with cells and reveal that precise control over the chemical and physical properties of nanostructures can affect stem cell fate even without the incorporation of specific epitopes

Kendiliğinden düzenlenen peptit nanoyapıların nanomalzeme üretiminde çok yönlü kullanılması

Cataloged from PDF version of thesis.Includes bibliographical references (leaves 130-139).Thesis (Ph. D.): Bilkent University, Materials Science and Nanotechnology Program, İhsan Doğramacı Bilkent University, 2015.Several peptides such as amyloid like peptides (ALPs) and peptide amphiphiles (PAs) were synthesized by solid phase peptide synthesis technique. These peptides were utilized in fabrication of nanostructured materials. ALPs with amino (Ac-KFFAAK-Am) and carboxylate (Ac-EFFAAE-Am) functional groups were used in growth of titanium dioxide (titania) in solution. On the other hand, PA with amino group (lauryl-VVAGK-Am) was used in growth of titania by atomic layer deposition method. Obtained nanostructured titania in each case was used in construction of dye-sensitized solar cells. Peptide amphiphile with phytochelatin mimetic sequence and adamantyl functionality (ADAc-6-Ahx-GECECECG-Am) was used in noncovalent functionalization of electrospun hydroxypropyl-β-cyclodextrin (HPβCD) mesh; HPβCD mesh functionalized with peptide was further used in metal ion scavenging. PA with sequence lauryl-VVAGH-Am was used in noncovalent encapsulation of zinc phthalocyanine derivative. New photophysical properties of encapsulated chromophore were studied and ultrafast energy transfer was observed. L and D peptide amphiphiles (L/D-pyrenebutyryl-6-Ahx-VVAGH-Am and L/D-lauryl-VVAGH-Am) were used to induce chiral organization of achiral chromophore (pyrene) in self-assembled nanofibers of PAs. Two strategies were involved to induce chiral organization: first strategy envisioned conjugation of pyrene to peptide sequence, whereas second strategy involved direct encapsulation of the chromophore. Achiral pyrene molecules organized in supramolecular chiral manner were observed to demonstrate circular dichroism.by Ruslan GarifullinPh.D

Triphenylphosphonium Moiety Modulates Proteolytic Stability and Potentiates Neuroprotective Activity of Antioxidant Tetrapeptides in Vitro

Although delocalized lipophilic cations have been identified as effective cellular and mitochondrial carriers for a range of natural and synthetic drug molecules, little is known about their effects on pharmacological properties of peptides. The effect of triphenylphosphonium (TPP) cation on bioactivity of antioxidant tetrapeptides based on the model opioid YRFK motif was studied. Two tetrapeptide variants with L-arginine (YRFK) and D-arginine (YrFK) were synthesized and coupled with carboxyethyl-TPP (TPP-3) and carboxypentyl-TPP (TPP-6) units. The TPP moiety noticeably promoted YRFK cleavage by trypsin, but effectively prevented digestion of more resistant YrFK attributed, respectively, to structure-organizing and shielding effects of the TPP cation on conformational variants of the tetrapeptide motif. The TPP moiety enhanced radical scavenging activity of the modified YRFK in a model Fenton-like reaction, whereas decreased reactivity was revealed for both YrFK and its TPP derivative. The starting motifs and modified oligopeptides, especially the TPP-6 derivatives, suppressed acute oxidative stress in neuronal PC-12 cells during a brief exposure similarly with glutathione. The effect of oligopeptides was compared upon culturing of PC-12 cells with CoCl2, L-glutamic acid, or menadione to mimic physiologically relevant oxidative states. The cytoprotective activity of oligopeptides significantly depended on the type of oxidative factor, order of treatment and peptide structure. Pronounced cell-protective effect was established for the TPP-modified oligopeptides, which surpassed that of the unmodified motifs. The protease-resistant TPP-modified YrFK showed the highest activity when administered 24 h prior to the cell damage. Our results suggest that the TPP cation can be used as a modifier for small therapeutic peptides to improve their pharmacokinetic and pharmacological properties

Technology for developing the professional competence of physical education teachers in architecture and construction university

The objective of this paper is to investigate the possibility of forming the professional competence of physical education teachers in a university of architecture and engineering. At the beginning of the experiment the baseline level of teachers' professional competence was determined in order to form the control and experimental groups among them. In the control group the formation of competence of teachers was carried out by taking professional development courses according to the «standard» program, according to which the participants were given lectures, seminars on various modules of the program, having to complete a course with a final qualifying paper on a selected topic. Teachers in the experimental group were trained according to the professional development programme, taking into account the developed model of competence formation. At the end of the training the previously studied indicators were tested in both groups and the data obtained was then compared. As a result, it was found that the professional competence level of teachers in the experimental group increased significantly compared to this in the control group. Thus, it showed that to be able to form teachers' professional competence «standard» professional development programmes currently implemented by Kazan State University of Architecture and Engineering are not enough. For effective formation of competence it is necessary to have a special technology of teachers' training, which is implemented in the developed pedagogical model of formation of teachers' professional competence

Current trends in the construction of sports infrastructure facilities, taking into account the direction of development of the international Olympic movement

The study aims to assess current trends in the construction of sports infrastructure, considering the development and improvement vectors of the Olympic movement. Materials and methods. The study utilizes literature analysis, statistical methods, expert assessment method and legal analysis. Results. Trends in the development of sports infrastructure facilities for the Olympic Games have been identified and substantiated. The currentdifficulties regarding organizing and holding of the Olympic Games and the uprising contradictions in the activities of international sports organizations have been structured. Analysis of trends in the development of the Olympic movement in the XXI century and recent decisions of the International Olympic Committee revealed particular problems in the organization of the Games. The proposed new model of the modern Olympic Games allowing to overcome problems and contradictions of the Olympic movement is described. Conclusion. The modern stage of development of the Olympic movement is characterized by a number of contradictions and problems that need to be solved: gigantism of the Olympic Games, subjectivity of refereeing at sports competitions, safety at sports events, etc. The proposed model of the organization of the Olympic Games in the form of long-term competitions during the Olympic Year may help to overcome existing contradictions

Control of the degradation of the mineral transformer oils hydrocarbon base

Currently, the degree of degradation of the oils hydrocarbon base remains outside the field of vision of operating services. The aim of this work was to analyse the process of regeneration of aged mineral transformer oils using adsorption cleaning. IR spectroscopy shows that the hydrocarbon composition of oils undergoes changes during operation. And those changes are cannot be restored. We propose the concept for the control of destruction degree of the mineral oils hydrocarbon base. The suggested criterion based on the IR method may be used when decision is making whether the transformer oil should be replaced with a new one

One-Dimensional Peptide Nanostructure Templated Growth of Iron Phosphate Nanostructures for Lithium-Ion Battery Cathodes

Template-directed synthesis of nanomaterials can provide benefits such as small crystalline size, high surface area, large surface-to-volume ratio, and structural stability. These properties are important for shorter distance in ion/electron movement and better electrode surface/electrolyte contact for energy storage applications. Here nanostructured FePO₄ cathode materials were synthesized by using peptide nanostructures as a template inspired by biomineralization process. The amorphous, high surface area FePO₄ nanostructures were utilized as a cathode for lithium-ion batteries. Discharge capacity of 155 mAh/g was achieved at C/20 current rate. The superior properties of biotemplated and nanostructured amorphous FePO₄ are shown compared to template-free crystalline FePO₄