Direct SUSY dark matter detection-Theoretical rates due to the spin

The recent WMAP data have confirmed that exotic dark matter together with the vacuum energy (cosmological constant) dominate in the flat Universe. Thus the direct dark matter detection, consisting of detecting the recoiling nucleus, is central to particle physics and cosmology. Supersymmetry provides a natural dark matter candidate, the lightest supersymmetric particle (LSP). The relevant cross sections arise out of two mechanisms: i) The coherent mode, due to the scalar interaction and ii) The spin contribution arising from the axial current. In this paper we will focus on the spin contribution, which is expected to dominate for light targets. For both modes it is possible to obtain detectable rates, but in most models the expected rates are much lower than the present experimental goals. So one should exploit two characteristic signatures of the reaction, namely the modulation effect and, in directional experiments, the correlation of the event rates with the sun's motion. In standard non directional experiments the modulation is small, less than two per cent. In the case of the directional event rates we like to suggest that the experiments exploit two features, of the process, which are essentially independent of the SUSY model employed, namely: 1) The forward-backward asymmetry, with respect to the sun's direction of motion, is very large and 2) The modulation is much larger, especially if the observation is made in a plane perpendicular to the sun's velocity. In this case the difference between maximum and minimum can be larger than 40 per cent and the phase of the Earth at the maximum is direction dependent.Comment: 16 Latex pages, 15 figures, 3 table

Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I : single component model

Twin-screw extruders are being increasingly applied in the pharmaceutical industry for the manufacture of solid dispersions. In particular, Hot Melt Extrusion (HME) is a viable manufacturing alternative for poorly soluble drugs that are difficult to process. This is due to the high shear stress applied in the process, which enhances mixing of the base polymer with the dispersed API. Delivery systems that can be obtained using this technology include pellets, granules, sustained release tablets and implants. Experiments for HME are typically very labour-intensive, involving the use of highly viscous polymers, high pressures, and require proper cleaning between runs. Identifying the critical experiments to perform based on model simulations would thus be highly desirable. Single-component modelling of twin-screw extrusion processes could be beneficial in the following areas: identifying optimal screw configurations, tracking the degree of melting and when identifying the area within the extruder where the polymer becomes completely melted

The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation

The iron-sulfur (FeS) cluster helicase DDX11 is associated with a human disorder termed Warsaw Breakage Syndrome. Interestingly, one disease-associated mutation affects the highly conserved arginine-263 in the FeS cluster-binding motif. Here, we demonstrate that the FeS cluster in DDX11 is required for DNA binding, ATP hydrolysis, and DNA helicase activity, and that arginine-263 affects FeS cluster binding, most likely because of its positive charge. We further show that DDX11 interacts with the replication factors DNA polymerase delta and WDHD1. In vitro, DDX11 can remove DNA obstacles ahead of Pol δ in an ATPase- and FeS domain-dependent manner, and hence generate single-stranded DNA. Accordingly, depletion of DDX11 causes reduced levels of single-stranded DNA, a reduction of chromatin-bound replication protein A, and impaired CHK1 phosphorylation at serine-345. Taken together, we propose that DDX11 plays a role in dismantling secondary structures during DNA replication, thereby promoting CHK1 activation

Scaling law for the electromagnetic form factors of the proton

The violation of the scaling law for the electric and magnetic form factors of the proton are examined within the cloudy bag model. The suppression of the ratio of the electric and magnetic form factors is natural in the bag model. The pion cloud plays a moderate role in understanding the recent data from TJNAF.Comment: 8 pages, REVTeX, 2 figures include

Antimicrobial susceptibility pattern of urine culture isolates in a tertiary care hospital of Jharkhand, India

Background: Urinary tract infection (UTI) is one of the common infections encountered by the clinicians. Though a good number of antimicrobial agents are available, still UTIs have become difficult to treat due to development of resistance by the uropathogens. So, regional data regarding the common uropathogens and their sensitivity pattern is required to guide the clinicians to start empirical therapy while managing UTIs. The purpose of the study was to identify different species of microorganisms, along with their antimicrobial susceptibility pattern, causing urinary tract infection in outpatient and indoor patients at RIMS, Ranchi, Jharkhand.Methods: Observational study was conducted using urine culture and sensitivity reports collected retrospectively from records maintained in the department of Microbiology over a period from July 2016 to Feb 2017 in tertiary care hospital.Results: UTI was more common in females (57.74%) than in males (42.26%). Among the uropathogens isolated Escherichia coli (37.41%) was found to be the predominant organism followed by Klebsiella species (32.79%), Pseudomonas species (25.86%), and gram-positive bacteria Staphylococcus aureus accounted (3.92%) of total cases. The most common isolates were E. coli showed high sensitivity to amikacin (79.24%), followed by levofloxacin (77.21%) and gentamycin (62.26%). It was found to be resistant to norfloxacin (86%), nalidixic acid (86.76%) and cefotaxime (69.88%).Conclusions: Though various microorganisms are responsible for UTI. Escherichia coli species is the most common organism. Antimicrobial resistance has already emerged against many antibiotics, making empirical treatment of these infections challenging

On the Nucleon Distribution Amplitude: The Heterotic Solution

We present a new nucleon distribution amplitude which amalgamates features of the Chernyak-Ogloblin-Zhitnitsky model with those of the Gari-Stefanis model. This "heterotic" solution provides the possibility to have asymptotically a small ratio \hbox{$\vert G_{M}^{n}\vert/G_{M}^{p}\le 0.1$}, while fulfilling most of the sum-rule requirements up to the third order. Using this nucleon distribution amplitude we calculate the electromagnetic and weak nucleon form factors, the transition form factor $\gamma p \Delta^{+}$ and the decay widths of the charmonium levels $^3S_{1}$, $^3P_{1}$, and $^3P_{2}$ into $p\bar p$. The agreement with the available data is remarkable in all cases.Comment: 15 pages, RUB-TPII-21/92 Preprin

Nucleon Charge and Magnetization Densities from Sachs Form Factors

Relativistic prescriptions relating Sachs form factors to nucleon charge and magnetization densities are used to fit recent data for both the proton and the neutron. The analysis uses expansions in complete radial bases to minimize model dependence and to estimate the uncertainties in radial densities due to limitation of the range of momentum transfer. We find that the charge distribution for the proton is significantly broad than its magnetization density and that the magnetization density is slightly broader for the neutron than the proton. The neutron charge form factor is consistent with the Galster parametrization over the available range of Q^2, but relativistic inversion produces a softer radial density. Discrete ambiguities in the inversion method are analyzed in detail. The method of Mitra and Kumari ensures compatibility with pQCD and is most useful for extrapolating form factors to large Q^2.Comment: To appear in Phys. Rev. C. Two new figures and accompanying text have been added and several discussions have been clarified with no significant changes to the conclusions. Now contains 47 pages including 21 figures and 2 table

New calculations of the PNC Matrix Element for the JπTJ^{\pi}T 0+1,0−1^{+}1,0^{-}1 doublet in 14^{14}N

A new calculation of the predominantly isoscalar PNC matrix element between the $J^{\pi}T$ $0^{+}1,0^{-}1$ (E$_{x} \approx$ 8.7 MeV) states in $^{14}$N has been carried out in a (0+1+2+3+4)$\hbar \omega$ model space with the Warburton-Brown interaction. The magnitude of the PNC matrix element of 0.22 to 0.34 eV obtained with the DDH PNC interaction is substantially suppressed compared with previous calculations in smaller model spaces but shows agreement with the preliminary Seattle experimental data. The calculated sign is opposite to that obtained experimentally, and the implications of this are discussed.Comment: REVTEX, 28 page

Parity Mixed Doublets in A = 36 Nuclei

The $\gamma$-circular polarizations ($P_{\gamma}$) and asymmetries ($A_{\gamma}$) of the parity forbidden M1 + E2 $\gamma$-decays: $^{36}Cl^{\ast} (J^{\pi} = 2^{-}; T = 1; E_{x} = 1.95$ MeV) $\rightarrow$ $^{36}Cl (J^{\pi} = 2^{+}; T = 1; g.s.)$ and $^{36}Ar^{\ast} (J^{\pi} = 2^{-}; T = 0; E_{x} = 4.97$ MeV) $\rightarrow$ $^{36}Ar^{\ast} (J^{\pi} = 2^{+}; T = 0; E_{x} = 1.97$ MeV) are investigated theoretically. We use the recently proposed Warburton-Becker-Brown shell-model interaction. For the weak forces we discuss comparatively different weak interaction models based on different assumptions for evaluating the weak meson-hadron coupling constants. The results determine a range of $P_{\gamma}$ values from which we find the most probable values: $P_{\gamma}$ = $1.1 \cdot 10^{-4}$ for $^{36}Cl$ and $P_{\gamma}$ = $3.5 \cdot 10^{-4}$ for $^{36}Ar$.Comment: RevTeX, 17 pages; to appear in Phys. Rev.

The Separable Kernel of Nucleon-Nucleon Interaction in the Bethe-Salpeter Approach

The dispersion relations for nucleon-nucleon (NN) T-matrix in the framework of Bethe-Salpeter equation for two spin one-half particle system and with separable kernel of interaction are considered in the paper. The developed expressions are applied for construction of the separable kernel of interaction for S partial-waves in singlet and triplet channels. We calculate the low energy scattering parameters and the phase shifts and also the deuteron binding energy with the separable interaction. The approach can be easily extended to higher partial-waves for NN-scattering and other reactions (anti N N-, pi N-scattering).Comment: RevTex 4 style, 9 pages, 1 figur