Studies on Potential Pesticides-Part XIV : Synthesis and Biological Activities of some new Thiosemicarbazide and Triazole Derivatives

Some new N-[5-(substituted phenoxymethyl)-1,3,4-oxadiazoly1-2-thioacetyl]-N-aryl-thiosemicarbazides have been synthesised by the condensation of appropriate hydrazine with aryliosothiocyanates. Cyclisation of these thiosemicarbazides in alkaline medium gives 3-[5-(substituted phenoxymethyl)-1,3,4-oxadiazolyl-2-thioacetyl]-4-aryl-5-mercapto-1,2,4-triazoles. All these compounds have been evaluated for their antibacterial properties and some of these have been screened for their anti fungal activity and AChE inhibition

Bilateral cortical blindness secondary to tuberculous meningitis in a young Indian female

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A Retrospective Cohort Study of Treatment Outcome among HIV positive and HIV negative TB patients in Chandigarh, India

Background: Tuberculosis (TB) and the HIV epidemics have been well known previously but now these are emerging as a combined epidemic to pose new public health challenges. TB is the most common opportunistic infection found among HIV positive individuals. Aims & Objective: To find the prevalence of HIV infection among the TB patients diagnosed and put on treatment under RNTCP. 2. To assess their treatment outcomes in Chandigarh. Material & Methods: The present study was designed as a retrospective cohort study among the adult population (>18 years) in Chandigarh from April 2012 - March 2014. All the TB patients registered for treatment at the 17 DMCs of Chandigarh, during this period were taken as the study population. The treatment outcome among TB-HIV co-infected patients was compared with those having only Tuberculosis. Results: From 1st April 2012 - 31st March 2013, a total of 3,551 patients were registered under RNTCP for treatment of tuberculosis. Among the total patients put on DOTS (3,551), 63.2% (2,246) were males and 36.7% (1,305) were females.  A total of 3,516 TB patients had their blood tested for HIV. Out of these patients, 88 (2.47%) were tested positive for HIV. HIV positive status was also found to be significantly associated with occurrence of extra pulmonary tuberculosis (X2= 17.42; df 2; p 0.0001). Category – II treatment was found to be slightly more among the HIV positive TB patients as compared to the HIV negative patients. From the total sample, 2.19% (78) patients were later diagnosed as having drug resistant tuberculosis with only one (01) patient being co-infected with HIV. Out of all the TB-HIV co-infected patients, 29.55% were declared cured at the end of the treatment. A total of 63.64% of co-infected patients had completed their treatment. Death as an outcome was significantly associated with HIV positive status (1.14%) as compared to HIV negative patients. Conclusion: Integration of TB-HIV collaborative activities at every level will strengthen our battle to control TB and HIV globally

Opterećenje tekućinom i prijenosna sposobnost bubrega u dvogrbe deve u dehidraciji i rehidraciji zimi i ljeti

The effect of dehydration and rehydration was studied during winter and summer on solute loads and transfer function of kidney in healthy adult female dromedary camels. Kidney solute loads (KSLs) which included plasma loads (PL) and tubular loads (TL) were determined for glucose, proteins, urea, creatinine, sodium, potassium, chloride, calcium and phosphorus. The dehydration period was of 24 days in winter and 13 days in summer. Water was provided ad libitum during control and rehydration periods and was restricted completely during dehydration period. The mean value of TFK during summer control was significantly (P≤0.05) lower than that in winter control. In winter the mean values of TFK during rehydration phases differed significantly (P≤0.05) from control values. A similar trend was observed during summer, except that the calculations for TFK could not be made at hour ½ and at hour 2 of rehydration since animals did not void urine. During dehydration periods in both seasons PL and TL mean values decreased significantly (P≤0.05) from respective control mean values. It was concluded that during dehydration reduction in kidney solute loads was indicative of the water conservation ability of camels because reduced plasma loads and tubular loads resulted in trapping of constituents in the plasma to hold more water.Istražen je učinak dehidracije i rehidracije u tijeku zime i ljeta na opterećenje tekućinom i prijenosnu sposobnost bubrega u zdravih ženki dvogrbe deve. Opterećenje obuhvaća plazmalno (PO) i tubularno (TO) opterećenje, a određivano je za glukozu, bjelančevine, mokraćevinu, kreatinin, natrij, kalij, klor, kalcij i fosfor. Razdoblje dehidracije trajalo je 24 dana zimi i 13 dana ljeti. Životinje su po volji pile vodu tijekom kontrolnoga i rehidracijskoga razdoblja, ali vodu nisu dobivale u tijeku dehidracijskoga razdoblja. Srednja vrijednost prijenosne sposobnosti bubrega u tijeku ljetnih mjeseci bila je značajno niža (P≤0,05) u odnosu na zimsko kontrolno razdoblje. Zimi su se srednje vrijednosti prijenosne sposobnosti bubrega za vrijeme rehidracije značajno razlikovale u odnosu na kontrolne vrijednosti (P≤0,05). Sličan je trend zabilježen ljeti, osim što izračuni nisu mogli biti učinjeni sat i pol te dva sata nakon rehidracije, jer životinje nisu izlučivale mokraću. Srednje vrijednosti PO i TO bile su značajno manje u odnosu na kontrolu (P≤0,05) u tijeku dehidracijskoga razdoblja u oba godišnja doba. Zaključuje se da je smanjeno opterećenje bubrega u tijeku dehidracije dobar pokazatelj sposobnosti čuvanja vode s obzirom na to da smanjeno plazmalno i tubularno opterećenje dovodi do zadržavanja sastojaka u plazmi koji imaju sposobnost osmotskoga zadržavanja vode

Ultrasonography: a diagnostic choice to localise intra uterine contraceptive devices

Background: Intrauterine devices are important method of contraception. They are more effective than oral contraceptives. They are also reversible forms of contraception. They provide contraception for years. Sonography is very useful in localization of intra uterine contraceptive devices. Before insertion, it tells us about uterine anomalies, tumours and shape of uterus. After IUCD insertion, it is helpful for locating IUCD and confirming the place where required and also tells us its relative position at follow up also.Methods: In this study, sonography is used for localization of Cu-T, IUCD by its four very important features namely, type-specific morphology, posterior acoustic shadowing, entrance-exit reflection, anechoic halo around the IUCD.Results: In this study, it was observed that 100 % localization of IUCD is possible by these parameters.Conclusions: It was concluded that ultrasonography acts as diagnostic tool for localization of Copper T IUCD

Osmotically Regulated Two-Compartment Asymmetric Membrane Capsules for Simultaneous Controlled Release of Anti-Hypertensive Drugs

In the present study, asymmetric membrane capsules (AMCs) with two compartments were successfully developed for simultaneous delivery of two poorly water-soluble drugs, Atenolol and Amlodipine Besylate, by using solubility modulation approach. Scanning electron microscopy (SEM) before dissolution showed presence of outer dense region and inner porous region for the prepared asymmetric membrane and the pore size increased after dissolution for both outer and inner layer. Diffuse reflectance spectroscopy (DRS) showed no incompatibility between the drug(s) and the excipients used in the study. The developed system was able to control the release of ATN and AMB by increasing the solubility through buffering agents of different strengths (0.25N to 1.0N). As the level of buffering agent was increased, the solubility of drugs also increased inside the asymmetric membrane capsule. The developed system was independent of the agitation intensity of the dissolution fluid but was dependent on the polymer diffusibility and osmotic pressure of the media, which clearly stated that osmotic pumping was the primary mechanism of drug(s) release from AMCs. The results of in-vitro demonstration of effect of membrane thickness on dissolution fluid entering AMCs showed that as the membrane thickness increased the volume of dissolution fluid entering into AMC decreased. The release kinetic studies of different formulations of AMCs showed that formulation code six, which consists of the highest amount of osmotic agents and optimum amount of buffering agents, was the best formulation, and it followed zero order release kinetics (r2=0.9990 for ATN and r2=0.9988 for AMB)

Rapid detection of dermatophytes from skin and hair

Abstract Background Dermatophytes are a group of closely related keratinophilic fungi that can invade keratinized humans and animals tissues such as skin, hair and nails causing dermatophytosis. They are an important cause of superficial fungal infection. Findings Conventional methods like potassium hydroxide (KOH) microscopy and fungal culture lacks the ability to make an early and specific diagnosis. In this study we have evaluated nested Polymerase chain reaction (PCR) using primers targeting dermatophyte specific sequence of chitin synthase 1 (CHS1) gene and compared with conventional test. A total of 155 patients clinically suspected with dermatophytosis were included in the study. Of which 105 specimens were skin scrapings and 50 were hair. KOH microscopy, fungal culture and first round and nested PCR were done on clinical specimens, and results compared. Nested PCR for dermatophytes was positive in 83.8% specimens, followed by KOH microscopy (70%), first round PCR (50.8) and fungal culture (25.8). Conclusion Results indicate that nested PCR may be considered as gold standard for the diagnosis of dermatophytosis and can aid the clinician in initiating prompt and appropriate antifungal therapy.</p

Polarographic Studies on La(III), Sm(III), Eu(III) & Yb(III) Complexes with Diethylenetriaminepentaacetic, Triethylenetetraminehexaacetic & Tetraethylenepentamineheptaacetic Acids

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Forensic Osteology and Identification

Every human corpse is unique. There are different religions in different parts of the world which adopt a variety of ways to dispose of corpses. Dead bodies can be found unattended, dug up, mutilated by the perpetrators of crimes, and eaten by wild animals in lonely unattended places. In these situations, forensic anthropologists or anatomists are consulted by the state authorities to help them to provide justice to the deceased person. The first and foremost scientific information desired by authorities is identification of the corpse, cause of death of the human body and weapon used, if applicable. Identification can be done by studying the bones of the human corpse during autopsy examination and if unknown skeletal remains are all that is available, examination of each bone is required. Forensic anthropologists or pathologists are asked to identify race, sex and age as important parameters of the identification. In this chapter, we will enumerate various parameters for identification. We will discuss race, age and sex from various bones as part of forensic oesteology