Balancing Risk Appetite and Risk Attitude in Requirements: a Framework for User Liberation

The tendency to throw controls at perceived and real system vulnerabilities, coupled with the likelihood of these controls being technical in nature, has the propensity to favour security over usability. However there is little evidence of increased assurance and it could encourage work stoppages or deviations that keep honest users from engaging with the system. The conflicting balance of trust and controls, and the challenge of turning that balance into clear requirements, creates an environment that alienates users and feeds the paranoia of actors who assume more ownership of the system than necessary. Security therefore becomes an inhibitor rather than an enabler for the community. This paper looks at measuring the balance of an organisation’s or a community’s risk appetite with the risk attitudes of its members in the early stages of IS development. It suggests how the dials of assurance can be influenced by the levers of good systems practice to create a cultural shift to trusting the users

The meaning of the 'impact factor' in the case of an open-access journal

The dominant model of journal evaluation emerged at the time when there were no open-access journals, and nobody has assessed yet whether this model is able to cope with this modern reality. This commentary attempts to fill the gaps in the common understanding of the role that 'impact factor' should play in evaluation of open-access journals

A System Dynamics Model to Predict Municipal Waste Generation and Management Costs in Developing Areas

This paper utilized system dynamics modeling as a new analytical approach to predict both the municipal waste generated and the associated disposal costs in developing areas. This approach facilitates the decomposition of general waste into its main components to enable municipalities to manage recyclables and find out the feasibility of performing recycling better rather than disposal by performing comparative disposal cost analysis. This study is different from previous work as it only considers population as a factor to predict the total waste generated and recycled, together with the associated expenditure and disposal cost savings. The approach is verified by applying it to a case study in Nablus and demonstrates the evaluation of the quantity and composition of generated waste by considering population as the main influencing factor. The quantity and composition of municipal solid waste was evaluated to identify opportunities for waste recycling in the Nablus municipality. Municipal solid waste was collected and classified into eight main physical categories. The system dynamics model enable the quantity of each generated component such as plastic and metals to be anticipated together with the cost of recycling or disposal

Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells

BACKGROUND: Dexamethasone suppressed inflammation and haemodynamic changes in an animal model of pulmonary arterial hypertension (PAH). A major target for dexamethasone actions is NF-κB, which is activated in pulmonary vascular cells and perivascular inflammatory cells in PAH. Reverse remodelling is an important concept in PAH disease therapy, and further to its anti-proliferative effects, we sought to explore whether dexamethasone augments pulmonary arterial smooth muscle cell (PASMC) apoptosis. METHODS: Analysis of apoptosis markers (caspase 3, in-situ DNA fragmentation) and NF-κB (p65 and phospho-IKK-α/β) activation was performed on lung tissue from rats with monocrotaline (MCT)-induced pulmonary hypertension (PH), before and after day 14–28 treatment with dexamethasone (5 mg/kg/day). PASMC were cultured from this rat PH model and from normal human lung following lung cancer surgery. Following stimulation with TNF-α (10 ng/ml), the effects of dexamethasone (10(−8)–10(−6) M) and IKK2 (NF-κB) inhibition (AS602868, 0–3 μM (0-3×10(−6) M) on IL-6 and CXCL8 release and apoptosis was determined by ELISA and by Hoechst staining. NF-κB activation was measured by TransAm assay. RESULTS: Dexamethasone treatment of rats with MCT-induced PH in vivo led to PASMC apoptosis as displayed by increased caspase 3 expression and DNA fragmentation. A similar effect was seen in vitro using TNF-α-simulated human and rat PASMC following both dexamethasone and IKK2 inhibition. Increased apoptosis was associated with a reduction in NF-κB activation and in IL-6 and CXCL8 release from PASMC. CONCLUSIONS: Dexamethasone exerted reverse-remodelling effects by augmenting apoptosis and reversing inflammation in PASMC possibly via inhibition of NF-κB. Future PAH therapies may involve targeting these important inflammatory pathways

A comparison of two methods of assessing the potential clinical importance of medication errors

BACKGROUND: A wide range of methods have been used to assess the potential clinical importance of medication errors, but it is neither clear which should be used, nor how they compare. In this paper, we compare two methods of assessment, using a dataset of errors identified in the administration of intravenous infusions in English hospitals, to inform future comparisons between studies. METHODS: We assessed each of 155 errors identified in a study of intravenous infusion administration using two commonly used methods: an adapted form of the National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) method (an ordinal scale scored by local clinicians) and the Dean and Barber method (an interval scale ranging from 0 to 10 scored by a group of experts). We compared the two sets of scores using a scatter plot and calculated Spearman’s correlation coefficient. RESULTS: Using the NCC MERP method, 137 (88%) errors were rated C (‘an error occurred but was unlikely to cause harm despite reaching the patient’), 17 (11%) rated D (‘an error occurred that would be likely to have required increased monitoring’) and 1 (1%) rated E (‘an error occurred that would be likely to have caused temporary harm’). Errors ranged from 0 to 4.75 on the Dean and Barber scale with a mean of 1.7; 138 (89%) of errors were considered minor (scores of less than 3) and 17 (11%) as moderate (scores 3–7). Scores from the two methods were significantly but weakly correlated (correlation coefficient = 0.36, p = < 0.01). CONCLUSION: Scores from the adapted NCC MERP and Dean and Barber methods are only weakly correlated in the assessment of medication administration errors. In the absence of a uniformly agreed standard method for assessing errors’ clinical importance, researchers should be aware that comparisons between studies are likely to have limitations

The Affordable Care Act and implications for health care services for American Indian and Alaska Native individuals

American Indian and Alaska Native (AI/AN) populations report poor physical and mental health outcomes while tribal health providers and the Indian Health Service (IHS) operate in a climate of significant under funding. Understanding how the Patient Protection and Affordable Care Act (ACA) affects Native American tribes and the IHS is critical to addressing the improvement of the overall access, quality, and cost of health care within AI/AN communities. This paper summarizes the ACA provisions that directly and/or indirectly affect the service delivery of health care provided by tribes and the IHS

Developing Workforce Capability in Nonprofits Through Effective Leadership

Leaders of nonprofit organizations in the United States must build workforce capabilities to meet increasing demands for services. This single-case study explored strategies nonprofit leaders used to build workforce capability to address increasing service demands. The conceptual lens for this study was the full-range leadership theory. Data were collected through semi-structured interviews with senior executives of a single nonprofit organization located in the Midwestern region of the United States, which included internal organizational and workforce performance data, strategy plans, annual reports internal and external financial documents, and publicly available information. Four major themes related to building workforce capacity emerged from a thematic analysis of the data: (1) an emphasis on employee development, (2) the expansion of technology systems, (3) a concentration on developing a culture of autonomy and trust, and (4) the introduction of processes and measurements. The findings from this study might contribute to positive social change by providing nonprofit leaders with strategies and data to support a deeper understanding of how to effectively build workforce capability to address increasing service demands