Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the Alzheimer’s Society and the Medical Research Council, and sourced from the MRC London Neurodegenerative Diseases Brain Bank, the Manchester Brain Bank, the South West Dementia Brain Bank (SWDBB), the Newcastle Brain Tissue Resource and the Oxford Brain Bank. The Newcastle Brain Tissue Resource and Oxford Brain Bank are also supported by the National Institute for Health Research (NIHR) Units. The South West Dementia Brain Bank (SWDBB) receives additional support from BRACE (Bristol Research into Alzheimer’s and Care of the Elderly). Alz-50, CP13, MC-1 and PHF-1 antibodies were gifted from Dr. Peter Davies and brain lystates from BACE1−/−mice were obtained from Prof Mike Ashford. The work presented here was funded by Alzheimer’s Research UK (Grant refs: ARUKPPG2014A-21 and ARUK-NSG2015-1 to BP and DK and NIH/NIA grants NIH/NINDS R01 NS082730 and R01 AG044372 to NK)Peer reviewedPublisher PD

Measuring the Value of Information Systems

Conference PaperBiomedical Informatic

Computers in the Emergency Room

journal articleBiomedical Informatic

The Role of Smart Medical Systems in the Space Station

journal articleBiomedical Informatic

Integrated Computer Systems for Monitoring of the Critically Ill

Conference PaperBiomedical Informatic

Signal Processing for Computerized Spirometry

book chapterBiomedical Informatic

Panel. History Makes Faulkner: Manufacturing a Mid-Century Reputation

Mr. Cowley\u27s Southern Saga: Cowley, Faulkner, and Canon-Building at Mid-Century / Sarah E. Gardner, Mercer UniversityMob Fury: Paperbacks and the Popular Politicization of Faulkner / David M. Earle, University of West FloridaReading Faulkner\u27s Readers: Reputation and Postwar Reading Revolution / Anna Creadick, Hobart and William Smith College

A Values-Based and Integral Perspective on Strategic Management

Landrum, Gardner, and Boje apply a Model for Integral Strategy which uses internal, competitive, and external tiers of strategic planning to combine economic, social, and environmental organizational imperatives with values, social responsibility, and sustainability. Their approach seeks to balance short-term with long-term objectives and economic with non-economic concerns all while addressing the sustainability challenges facing organizations today

Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry

In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry. Dogs were of similar age (control, 4.05 [1.85-7.70] v MCPD, 4.30 [3.25-6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P<0.001). Age, sex and neutered status had no effect on hair mineral status. Based on hair analysis, a role for mineral imbalance including copper, sulphur and zinc in the aetiopathogenesis of canine MCPD is suggested. Hair mineral analysis may prove useful as a biomarker for susceptible puppies