First Simultaneous Lidar Observations of Thermosphere‐Ionosphere Fe and Na (TIFe and TINa) Layers at McMurdo (77.84°S, 166.67°E), Antarctica With Concurrent Measurements of Aurora Activity, Enhanced Ionization Layers, and Converging Electric Field

We report the first simultaneous, common‐volume lidar observations of thermosphere‐ionosphere Fe (TIFe) and Na (TINa) layers in Antarctica. We also report the observational discovery of nearly one‐to‐one correspondence between TIFe and aurora activity, enhanced ionization layers, and converging electric fields. Distinctive TIFe layers have a peak density of ~384 cm−3 and the TIFe mixing ratio peaks around 123 km, ~5 times the mesospheric layer maximum. All evidence shows that Fe+ ion‐neutralization is the major formation mechanism of TIFe layers. The TINa mixing ratio often exhibits a broad peak at TIFe altitudes, providing evidence for in situ production via Na+ neutralization. However, the tenuous TINa layers persist long beyond TIFe disappearance and reveal gravity wave perturbations, suggesting a dynamic background of neutral Na, but not Fe, above 110 km. The striking differences between distinct TIFe and diffuse TINa suggest differential transport between Fe and Na, possibly due to mass separation

Measurements of the vertical fluxes of atomic Fe and Na at the mesopause: implications for the velocity of cosmic dust entering the atmosphere

The downward fluxes of Fe and Na, measured near the mesopause with the University of Colorado lidars near Boulder, and a chemical ablation model developed at the University of Leeds, are used to constrain the velocity/mass distribution of the meteoroids entering the atmosphere and to derive an improved estimate for the global influx of cosmic dust. We find that the particles responsible for injecting a large fraction of the ablated material into the Earth's upper atmosphere enter at relatively slow speeds and originate primarily from the Jupiter Family of Comets. The global mean Na influx is 17,200 ± 2800 atoms/cm2/s, which equals 298 ± 47 kg/d for the global input of Na vapor and 150 ± 38 t/d for the global influx of cosmic dust. The global mean Fe influx is 102,000 ± 18,000 atoms/cm2/s, which equals 4.29 ± 0.75 t/d for the global input of Fe vapor

Has education lost sight of children?

The reflections presented in this chapter are informed by clinical and personal experiences of school education in the UK. There are many challenges for children and young people in the modern education system and for the professionals who support them. In the UK, there are significant gaps between the highly selective education provided to those who pay privately for it and to the majority of those educated in the state-funded system. Though literacy rates have improved around the world, many children, particularly boys, do not finish their education for reasons such as boredom, behavioural difficulties or because education does not ‘pay’. Violence, bullying, and sexual harassment are issues faced by many children in schools and there are disturbing trends of excluding children who present with behavioural problems at school whose origins are not explored. Excluded children are then educated with other children who may also have multiple problems which often just make the situation worse. The experience of clinicians suggests that school-related mental health problems are increasing in severity. Are mental health services dealing with the consequences of an education system that is not meeting children’s needs? An education system that is testing- and performance-based may not be serving many children well if it is driving important decisions about them at increasingly younger ages. Labelling of children and setting them on educational career paths can occur well before they reach secondary schools, limiting potential very early on in their developmental trajectory. Furthermore, the emphasis at school on testing may come at the expense of creativity and other forms of intelligence, which are also valuable and important. Meanwhile the employment marketplace requires people with widely different skills, with an emphasis on innovation, creativity, and problem solving. Is education losing sight of the children it is educating

Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes

Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver

Long-Time Asymptotics for the Korteweg-de Vries Equation via Nonlinear Steepest Descent

We apply the method of nonlinear steepest descent to compute the long-time asymptotics of the Korteweg-de Vries equation for decaying initial data in the soliton and similarity region. This paper can be viewed as an expository introduction to this method.Comment: 31 page

A primary care, multi-disciplinary disease management program for opioid-treated patients with chronic non-cancer pain and a high burden of psychiatric comorbidity

BACKGROUND: Chronic non-cancer pain is a common problem that is often accompanied by psychiatric comorbidity and disability. The effectiveness of a multi-disciplinary pain management program was tested in a 3 month before and after trial. METHODS: Providers in an academic general medicine clinic referred patients with chronic non-cancer pain for participation in a program that combined the skills of internists, clinical pharmacists, and a psychiatrist. Patients were either receiving opioids or being considered for opioid therapy. The intervention consisted of structured clinical assessments, monthly follow-up, pain contracts, medication titration, and psychiatric consultation. Pain, mood, and function were assessed at baseline and 3 months using the Brief Pain Inventory (BPI), the Center for Epidemiological Studies-Depression Scale scale (CESD) and the Pain Disability Index (PDI). Patients were monitored for substance misuse. RESULTS: Eighty-five patients were enrolled. Mean age was 51 years, 60% were male, 78% were Caucasian, and 93% were receiving opioids. Baseline average pain was 6.5 on an 11 point scale. The average CESD score was 24.0, and the mean PDI score was 47.0. Sixty-three patients (73%) completed 3 month follow-up. Fifteen withdrew from the program after identification of substance misuse. Among those completing 3 month follow-up, the average pain score improved to 5.5 (p = 0.003). The mean PDI score improved to 39.3 (p < 0.001). Mean CESD score was reduced to 18.0 (p < 0.001), and the proportion of depressed patients fell from 79% to 54% (p = 0.003). Substance misuse was identified in 27 patients (32%). CONCLUSIONS: A primary care disease management program improved pain, depression, and disability scores over three months in a cohort of opioid-treated patients with chronic non-cancer pain. Substance misuse and depression were common, and many patients who had substance misuse identified left the program when they were no longer prescribed opioids. Effective care of patients with chronic pain should include rigorous assessment and treatment of these comorbid disorders and intensive efforts to insure follow up

Astrobiological Complexity with Probabilistic Cellular Automata

Search for extraterrestrial life and intelligence constitutes one of the major endeavors in science, but has yet been quantitatively modeled only rarely and in a cursory and superficial fashion. We argue that probabilistic cellular automata (PCA) represent the best quantitative framework for modeling astrobiological history of the Milky Way and its Galactic Habitable Zone. The relevant astrobiological parameters are to be modeled as the elements of the input probability matrix for the PCA kernel. With the underlying simplicity of the cellular automata constructs, this approach enables a quick analysis of large and ambiguous input parameters' space. We perform a simple clustering analysis of typical astrobiological histories and discuss the relevant boundary conditions of practical importance for planning and guiding actual empirical astrobiological and SETI projects. In addition to showing how the present framework is adaptable to more complex situations and updated observational databases from current and near-future space missions, we demonstrate how numerical results could offer a cautious rationale for continuation of practical SETI searches.Comment: 37 pages, 11 figures, 2 tables; added journal reference belo

A Real-Time Quantitative Analysis of Atmospheric Contributions of Hydrogen to Weld Arc Plasmas

Hydrogen contamination of weldments, particularly in the welded joints of high strength steels, can cause significant reductions in weld integrity, often resulting in failure of the joint. Inspection and repair of hydrogen assisted cracks in weldments is both costly and time consuming, thus real-time methods of detecting hydrogen levels during welding are essential. Analytical emission spectroscopy is a promising method of weld analysis, providing quantitative information in real time about the amount of hydrogen in the arc atmosphere

Lax pair and first integrals for two of nonlinear coupled oscillators

The system of two nonlinear coupled oscillators is studied. As partial case this system of equation is reduced to the Duffing oscillator which has many applications for describing physical processes. It is well known that the inverse scattering transform is one of the most powerful methods for solving the Cauchy problems of partial differential equations. To solve the Cauchy problem for nonlinear differential equations we can use the Lax pair corresponding to this equation. The Lax pair for ordinary differential or systems or for system ordinary differential equations allows us to find the first integrals, which also allow us to solve the question of integrability for differential equations. In this report we present the Lax pair for the system of coupled oscillators. Using the Lax pair we get two first integrals for the system of equations. The considered system of equations can be also reduced to the fourth-order ordinary differential equation and the Lax pair can be used for the ordinary differential equation of fourth order. Some special cases of the system of equations are considered.Comment: 9 page