Examining consent for interventional research in potential deceased organ donors: a narrative review

In the last decade, research in transplant medicine has focused on developing interventions in the management of the deceased organ donor to improve the quality and quantity of transplantable organs. Despite the promise of interventional donor research, there remain debates about the ethics of this research, specifically regarding gaining research consent. Here, we examine the concerns and ambiguities around consent for interventional donor research, which incorporate questions about who should consent for interventional donor research and what people are being asked to consent for. We highlight the US and UK policy responses to these concerns and argue that, whereas guidance in this area has done much to clarify these ambiguities, there is little consideration of the nature, practicalities and context around consent in this area, particularly regarding organ donors and their families. We review wider studies of consent in critical care research and social science studies of consent in medical research, to gain a broader view of consent in this area as a relational and contextual process. We contend a lack of consideration has been given to: what it might mean to consent to interventional donor research; how families, patients and health professionals might experience providing and seeking this consent; who is best placed to have these discussions; and the socio‐institutional contexts affecting these processes. Further, empirical research is required to establish an ethical and sensitive model for consent in interventional donor research, ensuring the principles enshrined in research ethics are met and public trust in organ donation is maintained

Stellar Populations in the Outskirts of the Small Magellanic Cloud: No Outer Edge Yet

We report the detection of intermediate-age and old stars belonging to the SMC at 6.5 kpc from the SMC center in the southern direction. We show, from the analysis of three high quality 34\arcmin $\times$ 33\arcmin CMDs, that the age composition of the stellar population is similar at galactocentric distances of $\thicksim$4.7 kpc, $\thicksim$5.6 kpc, and $\thicksim$6.5 kpc. The surface brightness profile of the SMC follows an exponential law, with no evidence of truncation, all the way out to 6.5 kpc. These results, taken together, suggest that the SMC `disk' population is dominating over a possible old Milky Way-like stellar halo, and that the SMC may be significantly larger than previously thought.Comment: Accepted for publication in ApJ Letters. High resolution figures are available at ftp://ftp.iac.es/out/noe

Quantum Kinetic Theory VI: The Growth of a Bose-Einstein Condensate

A detailed analysis of the growth of a BEC is given, based on quantum kinetic theory, in which we take account of the evolution of the occupations of lower trap levels, and of the full Bose-Einstein formula for the occupations of higher trap levels, as well as the Bose stimulated direct transfer of atoms to the condensate level introduced by Gardiner et al. We find good agreement with experiment at higher temperatures, but at lower temperatures the experimentally observed growth rate is somewhat more rapid. We also confirm the picture of the ``kinetic'' region of evolution, introduced by Kagan et al., for the time up to the initiation of the condensate. The behavior after initiation essentially follows our original growth equation, but with a substantially increased rate coefficient. Our modelling of growth implicitly gives a model of the spatial shape of the condensate vapor system as the condensate grows, and thus provides an alternative to the present phenomenological fitting procedure, based on the sum of a zero-chemical potential vapor and a Thomas-Fermi shaped condensate. Our method may give substantially different results for condensate numbers and temperatures obtained from phenomentological fits, and indicates the need for more systematic investigation of the growth dynamics of the condensate from a supersaturated vapor.Comment: TeX source; 29 Pages including 26 PostScript figure

Emergent classicality in continuous quantum measurements

We develop a classical theoretical description for nonlinear many-body dynamics that incorporates the back-action of a continuous measurement process. The classical approach is compared with the exact quantum solution in an example with an atomic Bose-Einstein condensate in a double-well potential where the atom numbers in both potential wells are monitored by light scattering. In the classical description the back-action of the measurements appears as diffusion of the relative phase of the condensates on each side of the trap. When the measurements are frequent enough to resolve the system dynamics, the system behaves classically. This happens even deep in the quantum regime, and demonstrates how classical physics emerges from quantum mechanics as a result of measurement back-action

Quantum turbulence in condensate collisions: an application of the classical field method

We apply the classical field method to simulate the production of correlated atoms during the collision of two Bose-Einstein condensates. Our non-perturbative method includes the effect of quantum noise, and provides for the first time a theoretical description of collisions of high density condensates with very large out-scattered fractions. Quantum correlation functions for the scattered atoms are calculated from a single simulation, and show that the correlation between pairs of atoms of opposite momentum is rather small. We also predict the existence of quantum turbulence in the field of the scattered atoms--a property which should be straightforwardly measurable.Comment: 5 pages, 3 figures: Rewritten text, replaced figure

Theory of the Ramsey spectroscopy and anomalous segregation in ultra-cold rubidium

The recent anomalous segregation experiment of Lewandowski et al. (PRL, 88, 070403, 2002) shows dramatic, rapid internal state segregation for two hyperfine levels of rubidium. We simulate an effective one dimensional model of the system for experimental parameters and find reasonable agreement with the data. The Ramsey frequency is found to be insensitive to the decoherence of the superposition, and is only equivalent to the interaction energy shift for a pure superposition. A Quantum Boltzmann equation describing collisions is derived using Quantum Kinetic Theory, taking into account the different scattering lengths of the internal states. As spin-wave experiments are likely to be attempted at lower temperatures we examine the effect of degeneracy on decoherence by considering the recent experiment of Lewandowski et al. where degeneracy is around 10%. We also find that the segregation effect is only possible when transport terms are included in the equations of motion, and that the interactions only directly alter the momentum distributions of the states. The segregation or spin wave effect is thus entirely due to coherent atomic motion as foreseen in the experimental reportComment: 26 pages, 4 figures, to be published in J. Phys.

Segregation by membrane rigidity in flowing binary suspensions of elastic capsules

Spatial segregation in the wall normal direction is investigated in suspensions containing a binary mixture of Neo-Hookean capsules subjected to pressure driven flow in a planar slit. The two components of the binary mixture have unequal membrane rigidities. The problem is studied numerically using an accelerated implementation of the boundary integral method. The effect of a variety of parameters was investigated, including the capillary number, rigidity ratio between the two species, volume fraction, confinement ratio, and the number fraction of the more floppy particle $X_f$ in the mixture. It was observed that in suspensions of pure species, the mean wall normal positions of the stiff and the floppy particles are comparable. In mixtures, however, the stiff particles were found to be increasingly displaced towards the walls with increasing $X_f$, while the floppy particles were found to increasingly accumulate near the centerline with decreasing $X_f$. The origins of this segregation is traced to the effect of the number fraction $X_f$ on the localization of the stiff and the floppy particles in the near wall region -- the probability of escape of a stiff particle from the near wall region to the interior is greatly reduced with increasing $X_f$, while the exact opposite trend is observed for a floppy particle with decreasing $X_f$. Simple model studies on heterogeneous pair collisions involving a stiff and a floppy particle mechanistically explain this observation. The key result in these studies is that the stiff particle experiences much larger cross-stream displacement in heterogeneous collisions than the floppy particle. A unified mechanism incorporating the wall-induced migration of deformable particles and the particle fluxes associated with heterogeneous and homogeneous pair collisions is presented.Comment: 19 Pages, 16 Figure

Nuclear quantum effects in solids using a colored-noise thermostat

We present a method, based on a non-Markovian Langevin equation, to include quantum corrections to the classical dynamics of ions in a quasi-harmonic system. By properly fitting the correlation function of the noise, one can vary the fluctuations in positions and momenta as a function of the vibrational frequency, and fit them so as to reproduce the quantum-mechanical behavior, with minimal a priori knowledge of the details of the system. We discuss the application of the thermostat to diamond and to ice Ih. We find that results in agreement with path-integral molecular dynamics can be obtained using only a fraction of the computational effort.Comment: submitted for publicatio

Tripartite entanglement and threshold properties of coupled intracavity downconversion and sum-frequency generation

The process of cascaded downconversion and sum-frequency generation inside an optical cavity has been predicted to be a potential source of three-mode continuous-variable entanglement. When the cavity is pumped by two fields, the threshold properties have been analysed, showing that these are more complicated than in well-known processes such as optical parametric oscillation. When there is only a single pumping field, the entanglement properties have been calculated using a linearised fluctuation analysis, but without any consideration of the threshold properties or critical operating points of the system. In this work we extend this analysis to demonstrate that the singly pumped system demonstrates a rich range of threshold behaviour when quantisation of the pump field is taken into account and that asymmetric polychromatic entanglement is available over a wide range of operational parameters.Comment: 24 pages, 15 figure