Concrete beams with externally bonded flexural FRP-reinforcement: analytical investigation of debonding failure

This paper studies the problem of early concrete cover delamination and plate-end failure of reinforced concrete beams strengthened with externally bonded FRP-reinforcement. The accuracy of analytical models and finite element (FE) methods for predicting this type of failure is assessed against published experimental data. Two design approaches based on the maximum concrete tensile strength and the shear capacity of concrete beams were examined first and it was found that linear elastic analysis cannot accurately predict the brittle plate-end concrete failure. It was also found that the extent of strengthening that can be achieved is limited by the shear capacity of concrete beams. The FE analysis is used to examine the effects of internal tensile reinforcement on the magnitude of principal tensile stresses in the critical region. The non-linear behaviour of FRP-strengthened beams is also examined in the FE analysis using the smeared crack model for concrete which is shown to adequately display the inelastic deformation of the beam. Finally, the mixed mode of failure due to the combined shear and concrete cover delamination is addressed through modelling plate-end and shear crack discontinuities using the discrete crack approach

修订后的 OECD 准则:解决 ESG 争议的强化论坛?

The 2023 OECD Guidelines for Multinational Enterprises on Responsible Business Conduct contain various revisions to their self-contained dispute resolution mechanism, before National Contact Points established by adhering States. This Perspective explores the revisions and the potential of the revised mechanism to “bite” multinational enterprises

Optimal Estimation Inversion of Ionospheric Electron Density from GNSS-POD Limb Measurements: Part I-Algorithm and Morphology

GNSS-LEO radio links from Precise Orbital Determination (POD) and Radio Occultation (RO) antennas have been used increasingly in characterizing the global 3D distribution and variability of ionospheric electron density (Ne). In this study, we developed an optimal estimation (OE) method to retrieve Ne profiles from the slant total electron content (hTEC) measurements acquired by the GNSS-POD links at negative elevation angles (ε \u3c 0°). Although both OE and onion-peeling (OP) methods use the Abel weighting function in the Ne inversion, they are significantly different in terms of performance in the lower ionosphere. The new OE results can overcome the large Ne oscillations, sometimes negative values, seen in the OP retrievals in the E-region ionosphere. In the companion paper in this Special Issue, the HmF2 and NmF2 from the OE retrieval are validated against ground-based ionosondes and radar observations, showing generally good agreements in NmF2 from all sites. Nighttime hmF2 measurements tend to agree better than the daytime when the ionosonde heights tend to be slightly lower. The OE algorithm has been applied to all GNSS-POD data acquired from the COSMIC-1 (2006–2019), COSMIC-2 (2019–present), and Spire (2019–present) constellations, showing a consistent ionospheric Ne morphology. The unprecedented spatiotemporal sampling of the ionosphere from these constellations now allows a detailed analysis of the frequency–wavenumber spectra for the Ne variability at different heights. In the lower ionosphere (~150 km), we found significant spectral power in DE1, DW6, DW4, SW5, and SE4 wave components, in addition to well-known DW1, SW2, and DE3 waves. In the upper ionosphere (~450 km), additional wave components are still present, including DE4, DW4, DW6, SE4, and SW4. The co-existence of eastward- and westward-propagating wave4 components implies the presence of a stationary wave4 (SPW4), as suggested by other earlier studies. Further improvements to the OE method are proposed, including a tomographic inversion technique that leverages the asymmetric sampling about the tangent point associated with GNSS-LEO links

Brief of Appellants

Fighting Arizona\u27s Attack on Ethnic Studies - Maya Arce, et al. v. John Huppenthal, et. a

Plaintiffs-Appellants/Cross-Appellees’Response and Reply Brief

Fighting Arizona\u27s Attack on Ethnic Studies - Maya Arce, et al. v. John Huppenthal, et. a

Brief of Amici Curiae Committee of Interns and Residents SEIU; Doctors Council SEIU; and Korean American Medical Association in Support of Respondent

Student clinic at Seattle University School of Law files amicus brief in employment discrimination retaliation case before the U.S. Supreme Court; brief warns of the adverse consequences weak anti-retaliation protections will have on public healt

Maya Arce, et al. v. Diane Douglas, et. al

Fighting Arizona\u27s Attack on Ethnic Studie

Brief of Amici Curiae Committee of Interns and Residents SEIU; Doctors Council SEIU; and Korean American Medical Association in Support of Respondent

Student clinic at Seattle University School of Law files amicus brief in employment discrimination retaliation case before the U.S. Supreme Court; brief warns of the adverse consequences weak anti-retaliation protections will have on public healt

ACVIM consensus statement on the treatment of immune thrombocytopenia in dogs and cats

Management of immune thrombocytopenia (ITP) in dogs and cats is evolving, but there are no evidence-based guidelines to assist clinicians with treatment decisions. Likewise, the overall goals for treatment of ITP have not been established. Immunosuppressive doses of glucocorticoids are the first line treatment, but optimal treatment regimens beyond glucocorticoids remain uncertain. Additional options include secondary immunosuppressive drugs such as azathioprine, modified cyclosporine, and mycophenolate mofetil, usually selected based on clinician preference. Vincristine, human IV immunoglobulin (hIVIg), and transfusion of platelet or red blood cell–containing products are often used in more severe cases. Splenectomy and thrombopoietin receptor agonists are usually reserved for refractory cases, but when and in which patient these modalities should be employed is under debate. To develop evidence-based guidelines for individualized treatment of ITP patients, we asked 20 Population Intervention Comparison Outcome (PICO) format questions. These were addressed by 17 evidence evaluators using a literature pool of 288 articles identified by a structured search strategy. Evidence evaluators, using panel-designed templates and data extraction tools, summarized evidence and created guideline recommendations. These were integrated by treatment domain chairs and then refined by iterative Delphi survey review to reach consensus on the final guidelines. In addition, 19 non-PICO questions covering scenarios in which evidence was lacking or of low quality were answered by expert opinion using iterative Delphi surveys with panelist integration and refinement. Commentary was solicited from multiple relevant professional organizations before finalizing the consensus. The rigorous consensus process identified few comparative treatment studies, highlighting many areas of ITP treatment requiring additional studies. This statement is a companion manuscript to the ACVIM Consensus Statement on the Diagnosis of Immune Thrombocytopenia in Dogs and Cats

ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats

Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. Immune thrombocytopenia less commonly affects cats but is an important cause of mortality and treatment-associated morbidity in both species. Immune thrombocytopenia remains a diagnosis of exclusion for which diagnostic guidelines are lacking. Primary, or non-associative, ITP refers to autoimmune platelet destruction. Secondary, or associative, ITP arises in response to an underlying disease trigger. However, evidence for which comorbidities serve as ITP triggers has not been systematically evaluated. To identify key diagnostic steps for ITP and important comorbidities associated with secondary ITP, we developed 12 Population Evaluation/Exposure Comparison Outcome (PECO) format questions. These questions were addressed by evidence evaluators utilizing a literature pool of 287 articles identified by the panelists using a structured search strategy. Evidence evaluators, using panel-designed templates and data extraction tools, summarized evidence and created guideline recommendations that then were integrated by diagnosis and comorbidity domain chairs. The revised PECO responses underwent a Delphi survey process to reach consensus on final guidelines. A combination of panel expertise and PECO responses were employed to develop algorithms for diagnosis of ITP in dogs and cats, which also underwent 4 iterations of Delphi review. Comorbidity evidence evaluators employed an integrated measure of evidence (IME) tool to determine evidence quality for each comorbidity; IME values combined with evidence summaries for each comorbidity were integrated to develop ITP screening recommendations, which also were subjected to Delphi review. Commentary was solicited from multiple relevant professional organizations before finalizing the consensus. The final consensus statement provides clinical guidelines for the diagnosis of, and underlying disease screening for, ITP in dogs and cats. The systematic consensus process identified numerous knowledge gaps that should guide future studies. This statement is a companion manuscript to the ACVIM Consensus Statement on the Treatment of Immune Thrombocytopenia