32 research outputs found
A probability-conserving cross-section biasing mechanism for variance reduction in Monte Carlo particle transport calculations
In Monte Carlo particle transport codes, it is often important to adjust
reaction cross sections to reduce the variance of calculations of relatively
rare events, in a technique known as non-analogous Monte Carlo. We present the
theory and sample code for a Geant4 process which allows the cross section of a
G4VDiscreteProcess to be scaled, while adjusting track weights so as to
mitigate the effects of altered primary beam depletion induced by the cross
section change. This makes it possible to increase the cross section of nuclear
reactions by factors exceeding 10^4 (in appropriate cases), without distorting
the results of energy deposition calculations or coincidence rates. The
procedure is also valid for bias factors less than unity, which is useful, for
example, in problems that involve computation of particle penetration deep into
a target, such as occurs in atmospheric showers or in shielding
Standards for Scalable Clinical Decision Support: Need, Current and Emerging Standards, Gaps, and Proposal for Progress
Despite their potential to significantly improve health care, advanced clinical decision support (CDS) capabilities are not widely available in the clinical setting. An important reason for this limited availability of CDS capabilities is the application-specific and institution-specific nature of most current CDS implementations. Thus, a critical need for enabling CDS capabilities on a much larger scale is the development and adoption of standards that enable current and emerging CDS resources to be more effectively leveraged across multiple applications and care settings. Standards required for such effective scaling of CDS include (i) standard terminologies and information models to represent and communicate about health care data; (ii) standard approaches to representing clinical knowledge in both human-readable and machine-executable formats; and (iii) standard approaches for leveraging these knowledge resources to provide CDS capabilities across various applications and care settings. A number of standards do exist or are under development to meet these needs. However, many gaps and challenges remain, including the excessive complexity of many standards; the limited availability of easily accessible knowledge resources implemented using standard approaches; and the lack of tooling and other practical resources to enable the efficient adoption of existing standards. Thus, the future development and widespread adoption of current CDS standards will depend critically on the availability of tooling, knowledge bases, and other resources that make the adoption of CDS standards not only the right approach to take, but the cost-effective path to follow given the alternative of using a traditional, ad hoc approach to implementing CDS
Growth inhibition properties of the putative prostate cancer biomarkers PSP94 and CRISP-3
Reduced Risk of Poststroke Pneumonia in Thrombolyzed Stroke Patients with Continued Statin Treatment
Evaluation of the prognostic significance of MSMB and CRISP3 in prostate cancer using automated image analysis
The prevalence of sexual behavior disorders in patients with treated and untreated gastroesophageal reflux disease
Recent trends in the analysis of amino acids in fruits and derived foodstuffs
The amino acid content of fruit and fruit-derived foods is intensely studied, because of their contribution to nutritional value, aroma, taste and health-promoting effects and their possible use as markers of origin and authenticity. In this review, based on 101 references, the most recent trends in the analysis of amino acids are presented: the most important techniques, the different sample treatment procedures (including derivatisation) and the most frequent applications are described and compared.
Pertinent publications were retrieved from Scopus and Web of Knowledge database searches lastly performed in February 2012 with the keywords "amino acid", "analysis", "liquid chromatography", "gas chromatography", "electrophoresis", "fruit", "vegetables"; the time limit was set from the year 2000 onwards.
Although amino acids have been analysed in foods for decades, new technical possibilities and advancements have allowed ever increasing accuracy and targeting of the methods, in order to overcome the challenges posed by the complex plant matrices and by their high intrinsic variability