Heart Rate Extraction from Novel Neck Photoplethysmography Signals.

This paper demonstrates for the first time how heart rate (HR) can be extracted from novel neck photoplethysmography (PPG). A novel algorithm is presented, which when tested in neck PPG signals recorded from 9 subjects at different respiratory rates, obtained good precision with respect to gold standard ECG signals. Mean absolute error (MAE), standard deviation error (SDAE) and root-mean-square error (RMSE) resulted in 1.22, 1.54 and 1.98 beats per minute (BPM), respectively. HRneck estimation showed strong correlation (R=0.94) with reference HRECG. Good agreement between both techniques was also demonstrated by Bland-Altman analysis. The bias between mean HR paired differences was -0.16 BPM and 95% limits of agreement (LoA) were (-4.7, 4.4). Comparatively, for widely used finger PPG, errors were slightly smaller (MAE=0.38 BPM, SDAE=0.48 BPM, RMSE=0.62BPM) and the correlation with reference ECG was also very close to 1 (R=0.99). Bias of -0.04 BPM and 95% LoA (-1.5, 1.4), also showed high degree of agreement. However, these findings show the potential the neck could have as an alternative body location for wearable monitors, aiming to reduce the number of sensing sites whilst still providing access to a wide variety of physiological parameters

Extracting the jugular venous pulse from anterior neck contact photoplethysmography

The jugular venous pulse (JVP) is the reference physiological signal used to detect right atrial and central venous pressure (CVP) abnormalities in cardio-vascular diseases (CVDs) diagnosis. Invasive central venous line catheterization has always been the gold standard method to extract it reliably. However, due to all the risks it entails, novel non-invasive approaches, exploiting distance cameras and lasers, have recently arisen to measure the JVP at the external and internal jugular veins. These remote options however, constraint patients to very specific body positions in front of the imaging system, making it inadequate for long term monitoring. In this study, we demonstrate, for the first time, that reflectance photoplethysmography (PPG) can be an alternative for extracting the JVP from the anterior jugular veins, in a contact manner. Neck JVP-PPG signals were recorded from 20 healthy participants, together with reference ECG and arterial finger PPG signals for validation. B-mode ultrasound imaging of the internal jugular vein also proved the validity of the proposed method. The results show that is possible to identify the characteristic a, c, v pressure waves in the novel signals, and confirm their cardiac-cycle timings in consistency with established cardiac physiology. Wavelet coherence values (close to 1 and phase shifts of ±180°) corroborated that neck contact JVP-PPG pulses were negatively correlated with arterial finger PPG. Average JVP waveforms for each subject showed typical JVP pulses contours except for the singularity of an unknown "u" wave occurring after the c wave, in half of the cohort. This work is of great significance for the future of CVDs diagnosis, as it has the potential to reduce the risks associated with conventional catheterization and enable continuous non-invasive point-of-care monitoring of CVP, without restricting patients to limited postures

Phenomenology Tools on Cloud Infrastructures using OpenStack

We present a new environment for computations in particle physics phenomenology employing recent developments in cloud computing. On this environment users can create and manage "virtual" machines on which the phenomenology codes/tools can be deployed easily in an automated way. We analyze the performance of this environment based on "virtual" machines versus the utilization of "real" physical hardware. In this way we provide a qualitative result for the influence of the host operating system on the performance of a representative set of applications for phenomenology calculations.Comment: 25 pages, 12 figures; information on memory usage included, as well as minor modifications. Version to appear in EPJ

Catalytic Conversion of Glucose and Chlorella sp. into Furans in the Presence of Niobium Oxide

A series of Nb2O5 solid catalysts have been prepared to be used for the catalytic dehydration of glucose and sugars from algae Chlorella sp. into added value furans. The glucose transformation gave rise to 5-hydroxymethylfurfural (5-HMF). Chlorella sp. was used in the same catalytic conditions to be valorised to furans. By preliminary studies we concluded that the algae aqueous suspension needed a previous treatment in the presence of SiO2 pellets to liberate the carbohydrates that in the catalytic reaction in the presence of Nb2O5 materials gave rise 5-HMF and furfural. The best operative conditions and Nb2O5 catalysts were individuated. The most performant Nb2O5 catalyst also showed an excellent reusability without deactivation. The selectivity to furans was related to the acidity of the solid used as catalyst

Cyanobacterial calcification in modern microbialites at the submicrometer scale

International audienceThe search for microfossils in the geological record has been a long-term challenge. Part of the problem comes from the difficulty of identifying such microfossils unambiguously, since they can be morphologically confused with abiotic biomorphs. One route to improve our ability to correctly identify microfossils involves studying fossilization processes affecting bacteria in modern settings. We studied the initial stages of fossilization of cyanobacterial cells in modern microbialites from Lake Alchichica (Mexico), a Mg-rich hyperalkaline crater lake (pH 8.9) hosting currently growing stromatolites composed of aragonite [CaCO3] and hydromagnesite [Mg5(CO3)4(OH)2 * 4(H2O)]. Most of the biomass associated with the microbialites is composed of cyanobacteria. Scanning electron microscopy analyses coupled with confocal laser scanning microscopy observations were conducted to co-localize cyanobacterial cells and associated minerals. These observations showed that cyanobacterial cells affiliated with the order Pleurocapsales become specifically encrusted within aragonite with an apparent preservation of cell morphology. Encrustation gradients from non-encrusted to totally encrusted cells spanning distances of a few hundred micrometers were observed. Cells exhibiting increased levels of encrustation along this gradient were studied down to the nm scale using a combination of focused ion beam (FIB) milling, transmission electron microscopy (TEM) and scanning transmission x-ray microscopy (STXM) at the C, O and N K-edges. Two different types of aragonite crystals were observed: one type was composed of needle-shaped nano-crystals growing outward from the cell body with a crystallographic orientation perpendicular to the cell wall, and another type was composed of larger crystals that progressively filled the cell interior. Exopolymeric substances (EPS), initially co-localized with the cells, decreased in concentration and dispersed away from the cells while crystal growth occurred. As encrustation developed, EPS progressively disappeared, but remaining EPS showed the same spectroscopic signature. In the most advanced stages of fossilization, only the textural organization of the two types of aragonite recorded the initial cell morphology and spatial distribution

On the origin of X-ray oxygen emission lines in obscured AGN

We present the Catalogue of High Resolution Spectra of Obscured Sources (CHRESOS) from the XMM-Newton Science Archive. It comprises the emission-line luminosities of H- and He-like transitions from C to Si, and the Fe 3C and Fe 3G L-shell ones. Here, we concentrate on the soft X-ray OVII (f) and OVIII Ly alpha emission lines to shed light on to the physical processes with which their formation can be related to active galactic nucleus (AGN) versus star-forming regions. We compare their luminosity with that of two other important oxygen key lines [O III]lambda 5007 angstrom, in the optical, and [O IV] 25.89 mu m, in the infrared (IR). We also test OVII (f) and OVIII Ly alpha luminosities against that of continuum bands in the IR and hard X-rays, which point to different ionization processes. We probe into those processes by analysing photoionization and collisional ionization model predictions upon our lines. We show that both scenarios can explain the formation and observed intensities of OVII (f) and OVIII Ly alpha. By analysing the relationships between OVII (f) and OVIII Ly alpha, and all other observables: [OIII]lambda 5007 angstrom, [O IV] 25.89 mu m emission lines, and mid-infrared (MIR) 12 mu m, far-infrared (FIR) 60 and 100 mu m, 2-10 and 14-195 keV continuum bands, we conclude that the AGN radiation field is mainly responsible of the soft X-ray oxygen excitation

Photocatalytic CO 2 Valorization by Using Ti O2 , ZrO2 and Graphitic Based Semiconductors

In this century, a broad scientific interest has been devoted to fulfill sustainable industrial processes and climatic change remediation. In this prospective, various green technologies have been studied to valorize CO 2• The aim of this research is the CO 2 reduction in presence of water by using the photocatalytic technology with nanomaterials as the photocatalysts. The present work overviews the main outcomes obtained by using graphitic and oxide based photocatalysts both in gas/solid and liquid/solid batch reactors under simulated solar light. In all gas/solid regime tests the major products detected were methane, carbon monoxide, and acetaldehyde

Selective oxidation of aromatic alcohols in the presence of C3N4 photocatalysts derived from the polycondensation of melamine, cyanuric and barbituric acids

A set of C3N4 samples has been prepared by using melamine, cyanuric acid and barbituric acid as the precursors. The materials were subjected both to physical and chemical characterization and were used as photocatalysts for the selective oxidation of aromatic alcohols in water suspension under UV and visible irradiation. The photoactivity of the materials versus the partial oxidation of four substituted benzyl alcohols was investigated. The type and position of the substituents in the aromatic molecule influenced conversion and selectivity to the corresponding aldehyde. The presence of barbituric and cyanuric acids in the preparation method has changed the graphitic-C3N4 structure, and therefore both the characteristics of the material and the ability of light to activate the surface of the photocatalyst. The most active material prepared in the presence of melamine and cyanuric acid showed a remarkable selectivity towards the aldehyde even under visible irradiation

Sox9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin

The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance and commonly overexpressed in solid cancers including colorectal cancer. In this study, we show that SOX9 levels are higher in metastatic (SW620) than in primary colorectal cancer cells (SW480) derived from the same patient. This elevated expression correlated with enhanced self-renewal activity. By gain and loss-of-function studies in SW480 and SW620 cells respectively, we reveal that SOX9 levels modulate tumorsphere formation and self-renewal ability in vitro and tumor initiation in vivo. Moreover, SOX9 regulates migration and invasion and triggers the transition between epithelial and mesenchymal states. These activities are partially dependent on SOX9 post-transcriptional modifications. Importantly, treatment with rapamycin inhibits self-renewal and tumor growth in a SOX9- dependent manner. These results identify a functional role for SOX9 in regulating colorectal cancer cell plasticity and metastasis, and provide a strong rationale for a rapamycin-based therapeutic strategy.published_or_final_versio

On the MBM12 Young Association

I present a comprehensive study of the MBM12 young association (MBM12A). By combining infrared (IR) photometry from the Two-Micron All-Sky Survey (2MASS) survey with new optical imaging and spectroscopy, I have performed a census of the MBM12A membership that is complete to 0.03 Msun (H~15) for a 1.75deg X 1.4deg field encompassing the MBM12 cloud. I find five new members with masses of 0.1-0.4 Msun and a few additional candidates that have not been observed spectroscopically. From an analysis of optical and IR photometry for stars in the direction of MBM12, I identify M dwarfs in the foreground and background of the cloud. By comparing the magnitudes of these stars to those of local field dwarfs, I arrive at a distance modulus 7.2+/-0.5 (275 pc) to the MBM12 cloud; it is not the nearest molecular cloud and is not inside the local bubble of hot ionized gas as had been implied by previous distance estimates of 50-100 pc. I have also used Li strengths and H-R diagrams to constrain the absolute and relative ages of MBM12A and other young populations; these data indicate ages of 2 +3/-1 Myr for MBM12A and 10 Myr for the TW Hya and Eta Cha associations. MBM12A may be a slightly evolved version of the aggregates of young stars within the Taurus dark clouds (~1 Myr) near the age of the IC 348 cluster (~2 Myr).Comment: to be published in The Astrophysical Journal, 41 pages, 14 figures, also found at http://cfa-www.harvard.edu/sfgroup/preprints.htm