Evaluation of Anonymized ONS Queries

Electronic Product Code (EPC) is the basis of a pervasive infrastructure for the automatic identification of objects on supply chain applications (e.g., pharmaceutical or military applications). This infrastructure relies on the use of the (1) Radio Frequency Identification (RFID) technology to tag objects in motion and (2) distributed services providing information about objects via the Internet. A lookup service, called the Object Name Service (ONS) and based on the use of the Domain Name System (DNS), can be publicly accessed by EPC applications looking for information associated with tagged objects. Privacy issues may affect corporate infrastructures based on EPC technologies if their lookup service is not properly protected. A possible solution to mitigate these issues is the use of online anonymity. We present an evaluation experiment that compares the of use of Tor (The second generation Onion Router) on a global ONS/DNS setup, with respect to benefits, limitations, and latency.Comment: 14 page

W-NINE: a two-stage emulation platform for mobile and wireless systems

More and more applications and protocols are now running on wireless networks. Testing the implementation of such applications and protocols is a real challenge as the position of the mobile terminals and environmental effects strongly affect the overall performance. Network emulation is often perceived as a good trade-off between experiments on operational wireless networks and discrete-event simulations on Opnet or ns-2. However, ensuring repeatability and realism in network emulation while taking into account mobility in a wireless environment is very difficult. This paper proposes a network emulation platform, called W-NINE, based on off-line computations preceding online pattern-based traffic shaping. The underlying concepts of repeatability, dynamicity, accuracy and realism are defined in the emulation context. Two different simple case studies illustrate the validity of our approach with respect to these concepts

Comparative analysis of the solar energy role in the supply of electricity in Spain and California

Solar energy resources have become one of the greatest options among renewable energy sources around the world, as they have had a huge development in terms of technical efficiency, that has come alongside with a great reduction of the manufacturing cost during recent times. These two factors combined made solar energy very attractive as an energy source, especially in a world with increasing need in terms of energy consumption, and with the urgency of reducing CO2 emissions that pollute the atmosphere. The main objective of this thesis is to provide a better understanding of the two solar energy technologies, solar photovoltaic (PV) and concentrated solar power (CSP) that have evolved over the last decade in two key regions in the world – California in the US and Spain in Europe. These two regions are among the early adopters of solar of technologies and have been at the forefront of its rapid development. We shall determine what have been the differences in the introduction of these technologies into the grid during the period studied, from 2008 to 2018 and how the level of performance in terms of the capacity factor (c.f.) has developed during those years. For doing so, we will determine the main characteristics of the electricity power systems of both regions, the consumption, in-region generation, peak load, role of renewables in the grid among others, to then focus on solar PV and CSP. We will look at the evolution of the capacity installed and generation of both technologies in both regions, how the level of performance has been year to year, to then make an analysis on the amount of CO2 emissions avoided by the electricity generation of solar resources using two different methods. Also, a brief analysis on the difference in cost and the levelized cost of energy of solar PV and CSP is made.Ope

Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats

Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury. The purpose of this study was to assess the neuroprotective effect and the neurological outcome after pyruvate administration in a model of ischemic stroke induced by permanent middle cerebral artery occlusion (pMCAO) in rats. Three doses of pyruvate (250, 500 and 1000 mg/kg, i.p.) or vehicle were administered intraperitoneally 30 min after pMCAO. In other set of experiments, pyruvate was given either before, immediately after ischemia or in a long-term administration paradigm. Functional outcome, mortality and infarct volume were determined 24 h after stroke. Even when the lowest doses of pyruvate reduced mortality and neurological deficits, no concomitant reduction in infarct volume was observed. The highest dose of pyruvate increased cortical infarction by 27% when administered 30 min after pMCAO. In addition, when pyruvate was given before pMCAO, a significant increase in neurological deficits was noticed. Surprisingly, on the contrary of what was found in the case of transient global ischemia, present findings do not support a great neuroprotective role for pyruvate in permanent focal cerebral ischemia, suggesting two distinct mechanisms involved in the effects of this glycolytic metabolite in the ischemic brain

Gamma-rays from Heavy Minimal Dark Matter

We consider the annihilation into gamma rays of Minimal Dark Matter candidates in the fermionic 5-plet and scalar 7-plet representations of $SU(2)_L$, taking into account both the Sommerfeld effect and the internal bremsstrahlung. Assuming the Einasto profile, we show that present measurements of the Galactic Center by the H.E.S.S. instrument exclude the 5-plet and 7-plet as the dominant form of dark matter for masses between 1 TeV and 20 TeV, in particular, the 5-plet mass leading to the observed dark matter density via thermal freeze-out. We also discuss prospects for the upcoming Cherenkov Telescope Array, which will be able to probe even heavier dark matter masses, including the scenario where the scalar 7-plet is thermally produced.Comment: 27 pages, 8 figures. Matches the version accepted for publication by JCA

Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats

Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition of COX-1 with valeryl salicylate (VAS, 12-120 mg/kg) on prostaglandin E2 (PGE2) levels, myeloperoxidase (MPO) activity, Evans Blue (EB) extravasation and infarct volume in a standardized model of transient focal cerebral ischemia in the rat. Postischemic treatment with nimesulide markedly reduced the increase in PGE2 levels in the ischemic cerebral cortex 24 h after stroke and diminished infarct size by 48 % with respect to vehicle-treated animals after 3 days of reperfusion. Furthermore, nimesulide significantly attenuated the blood-brain barrier (BBB) damage and leukocyte infiltration (as measured by EB leakage and MPO activity, respectively) seen at 48 h after the initial ischemic episode. These studies provide the first experimental evidence that COX-2 inhibition with nimesulide is able to limit BBB disruption and leukocyte infiltration following transient focal cerebral ischemia. Neuroprotection afforded by nimesulide is observed even when the treatment is delayed until 6 h after the onset of ischemia, confirming a wide therapeutic window of COX-2 inhibitors in experimental stroke. On the other hand, selective inhibition of COX-1 with VAS had no significant effect on the evaluated parameters. These data suggest that COX-2 activity, but not COX-1 activity, contributes to the progression of focal ischemic brain injury, and that the beneficial effects observed with non-selective COX inhibitors are probably associated to COX-2 rather than to COX-1 inhibition

Latest clinical recommendations on valproate use for migraine prophylaxis in women of childbearing age. Overview from European Medicines Agency and European Headache Federation

Migraine is a common and burdensome neurological condition which affects mainly female patients during their childbearing years. Valproate has been widely used for the prophylaxis of migraine attacks and is also included in the main European Guidelines. Previous (2014) European recommendations on limiting the use of valproate in women of childbearing age did not achieve their objective in terms of limiting the use of valproate in women of childbearing age and raising awareness regarding the hazardous effect of valproate to children exposed in utero. The teratogenic and foetotoxic effects of valproate are well documented, and more recent studies show that there is an even greater neurodevelopmental risk to children exposed to valproate in the womb. The latest 2018 European review from the European Medicines Agency, with the active participation of the European Headache Federation, concluded that not enough has been done to mitigate the risks associated with in utero exposure to valproate. The review called for more extensive restrictions to the conditions for prescribing, better public awareness, and a more effective education campaign in migrainous women

Bioschemas:schema.org for the Life Sciences

Websites are commonly used to expose data to end users, enabling search, filter, and download capabilities making it easier for users to find, organize and obtain data relevant to their own interests. With the continuous growth of data in the Life Sciences domain, it becomes difficult for users to easily find information required for their research on one single website. Search engines should make it easier for researchers to search and retrieve collated information from multiple sites so they can better decide where to go next. Schema.org is a collaborative project providing schemas for semantically structuring data in web pages. By adding semantic mark-up it becomes easier to determine whether a web page refers to a book or a movie. It also facilitates summarizing information in a fashion similar to infoboxes used in Wikipedia. Bioschemas is a community effort aiming to extend schema.org to support mark-up for Life Sciences websites. Here we present an overview of the main types used and proposed by Bioschemas in order to support such mark up