Evaluación del aprendizaje en asignaturas de máster con alumnos procedentes de diferentes grados.

Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524Se ha realizado un estudio comparativo del aprendizaje alcanzado por los alumnos de dos Másters oficiales en dos asignaturas de la misma área de conocimiento, en función de los estudios previos cursados por los alumnos y de otros factores. Las asignaturas estudiadas han sido: “Desarrollo y formulación de formas farmacéuticas” en el Máster oficial de Investigación, Desarrollo y Control de Medicamentos y “Nanotecnología farmacéutica” en el Máster oficial “Nanociencia y Nanotecnología”, durante los cursos académicos 2010-11, 2011-12, 2012-13, 2013-14. Ambas asignaturas, de 5 ECTS, abarcan competencias relacionadas con la adquisición e integración de conocimientos, habilidades y aptitudes relacionados con la Farmacia Galénica..

Ethylcellulose nanoparticles as a new "in vitro" transfection tool for antisense oligonucleotide delivery

Oil-in-water nano-emulsions have been obtained in the HEPES 20 mM buffer solution / [Alkylamidoammonium:Kolliphor EL = 1:1] / [6 wt% ethylcellulose in ethyl acetate] system over a wide oil-to-surfactant range and above 35 wt% aqueous component at 25 °C. The nano-emulsion with an oil-to-surfactant ratio of 70/30 and 95 wt% aqueous component was used for nanoparticles preparation. These nanoparticles (mean diameter around 90 nm and zeta potential of +22 mV) were non-toxic to HeLa cells up to a concentration of 3 mM of cationic species. Successful complexation with an antisense phosphorothioate oligonucleotide targeting Renilla luciferase mRNA was achieved at cationic/anionic charge ratios above 16, as confirmed by zeta potential measurements and an electrophoretic mobility shift assay, provided that no Fetal Bovine Serum is present in the cell culture medium. Importantly, Renilla luciferase gene inhibition shows an optimum efficiency (40%) for the cationic/anionic ratio 28, which makes these complexes promising for "in vitro" cell transfection

Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation

Novel emulsions with a nanostructured continuous phase have been proposed as controlled drug delivery systems to enhance topical delivery of active ingredients avoiding systemic effects. In this study, oil-in-water (O/W) emulsions with two surfactant/water (S/W) weight ratios of 40:60 and 35:65, and oil concentrations of 10 wt% (diluted emulsion), 40 wt% (concentrated emulsion) and 85 wt% (highly concentrated emulsion) have been investigated to identify the presence of liquid crystalline structures and their influence on drug release and skin permeation. The emulsions have been characterized in terms of visual appearance, rheology and drug release. The presence of cubic liquid crystalline structures in emulsions with S/W 40:60 was confirmed by small angle X-ray scattering (SAXS). Rheology results showed a markedly different behaviour in emulsions with S/W 40:60 compared with nonstructured emulsions. A model drug, diclofenac sodium (DS) was successfully incorporated in the emulsions. DS release was studied with hydrophilic and lipophilic membranes, and the amount of DS in the receptor solution was significantly lower in the formulations containing cubic liquid structures. An in vitro skin permeation study with dermatomed human skin showed that emulsions with a nanostructured continuous phase are suitable formulations for topical delivery with DS retention in skin layers. The results indicate that the amount of drug retained in skin structures may be tuned by modification of liquid crystal concentration and emulsion structure

Formation of nanoemulsion containing ibuprofen by PIC method for topical delivery

This study reports the formation of nanoemulsions from palm-kernel oil esters (PKOE)/Cremophor EL/water systems intended for topical administration of a non-steroidal anti-inflammatory drug, ibuprofen. Nanoemulsions containing 2% ibuprofen, various oil:surfactant ratios (10:90, 20:80 and 30:70) and 80% of water were selected from the ternary system of PKOE/Cremophor EL/water and prepared by the phase inversion composition (PIC) method. The characterization of the nanoemulsions such as droplet size, polydispersity index, zeta potential, stability and the permeation of ibuprofen from nanoemulsions were evaluated. The prepared nanoemulsions exhibited good stability without any phase separation, sedimentation or creaming for the period of tested experimental time (6 months). The permeation study of ibuprofen was performed on Franz type-diffusion cells through human abdominal skin. The median values of the fluxes obtained as well as the median of the percentage of permeated amount at 24h were not statistically different. The mean profiles of permeated ibuprofen versus time from PKOE was greater (p < 0.05) than those obtained from Miglyol 812

Rellevància de la competència transversal Capacitat d'aprenentatge i responsabilitat en l'àmbit de Ciències de la Salut

Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/43352Se determina la relevancia y la modalidad de trabajo (Presencial, semipresencial o no presencial) del conjunto de las cinco sub-competencias (Capacidad de análisis y de síntesis - Aplicar conocimientos a la práctica - Resolver problemas y tomar deci-siones - Capacitado para adaptarse a nuevas situaciones - Asumir responsabilida-des), ligadas a la competencia transversal Capacidad de aprendizaje y responsabili-dad, en los estudios de grado de Ciencias de la Salud de la UB y URL

Grup D’Innovació Docent en Anàlisi Instrumental Farmacèutic (GIDAIF)

Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/4335

Grup D’Innovació Docent en Anàlisi Instrumental Farmacèutic (GIDAIF)

Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/4335