Diseño de Estrategias de Mercadotecnia para una Microempresa caso La Huasteca

La siguiente investigación tiene como objetivo primordial sugerir a los propietarios de la microempresa “La Huasteca” estrategias de mercadotecnia que ayuden a dar a conocer, posicionar y retener a los clientes actuales. La principal problemática que tiene la microempresa es que no tiene ninguna estrategia de publicidad, por tal motivo las personas de la región de Amecameca al no conocer la existencia de la misma recurre a otras empresas para adquirir los productos

Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats

CRUE-CSIC (Acuerdos Transformativos 2021)Increased dopaminergic activity in the striatum underlies the neurobiology of psychotic symptoms in schizophrenia (SZ). Beyond the impaired connectivity among the limbic system, the excess of dopamine could lead to inflammation and oxidative/nitrosative stress. It has been suggested that atypical antipsychotic drugs attenuate psychosis not only due to their modulatory activity on the dopaminergic/serotonergic neurotransmission but also due to their anti-inflammatory/antioxidant effects. In such a manner, we assessed the effects of the atypical antipsychotic risperidone (RISP) on the structural neuroplasticity and biochemistry of the striatum in adult rats with neonatal ventral hippocampus lesion (NVHL), which is a developmental SZ-related model. RISP administration (0.25 mg/kg, i.p.) ameliorated the neuronal atrophy and the impairments in the morphology of the dendritic spines in the spiny projection neurons (SPNs) of the ventral striatum (nucleus accumbens: NAcc) in the NVHL rats. Also, RISP treatment normalized the pro-inflammatory pathways and induced the antioxidant activity of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in this model. Our results point to the neurotrophic, antiinflammatory, and antioxidant effects of RISP, together with its canonical antipsychotic mechanism, to enhance striatum function in animals with NVHL.Ministerio de Economía y Competitividad (MINECO)/FEDERCONACYTDepto. de Farmacología y ToxicologíaFac. de MedicinaTRUEpu