47,716 research outputs found
Determination of a set of constitutive equations for an al-li alloy at SPF conditions
© 2015 The Authors.Uniaxial tensile tests of aluminium-lithium alloy AA1420wereconducted at superplastic forming conditions. The mechanical properties of this Al-Li alloy were then modelled by a set of physicallybased constitutive equations. The constitutive equations describe the isotropic work hardening,recovery and damage by dislocation density changes and grain size evolution. Based on a recent upgraded optimisation technique, the material constants for these constitutive equations were determined
E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I
p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified. Further, the p62-mediated protein aggregation's effect on autophagy is unclear. We systemically analyzed the interactions of p62 with all known Atg proteins involved in LC3 lipidation. We find that p62 does not interact with LC3 at the stages when it is being processed by Atg4B or when it is complexed or conjugated with Atg3. p62 does interact with LC3-I and LC3-I:Atg7 complex and is preferentially recruited by LC3-II species under autophagic stimulation. Given that Atg4B, Atg3 and LC3-Atg3 are indispensable for LC3-II conversion, our study reveals a protective mechanism for Atg4B, Atg3 and LC3-Atg3 conjugate from being inappropriately sequestered into p62 aggregates. Our findings imply that p62 could potentially impair autophagy by negatively affecting LC3 lipidation and contribute to the development of protein aggregate diseases. © 2013 Gao et al
Neutron skin uncertainties of Skyrme energy density functionals
Background: Neutron-skin thickness is an excellent indicator of isovector
properties of atomic nuclei. As such, it correlates strongly with observables
in finite nuclei that depend on neutron-to-proton imbalance and the nuclear
symmetry energy that characterizes the equation of state of neutron-rich
matter. A rich worldwide experimental program involving studies with rare
isotopes, parity violating electron scattering, and astronomical observations
is devoted to pinning down the isovector sector of nuclear models. Purpose: We
assess the theoretical systematic and statistical uncertainties of neutron-skin
thickness and relate them to the equation of state of nuclear matter, and in
particular to nuclear symmetry energy parameters. Methods: We use the nuclear
superfluid Density Functional Theory with several Skyrme energy density
functionals and density dependent pairing. To evaluate statistical errors and
their budget, we employ the statistical covariance technique. Results: We find
that the errors on neutron skin increase with neutron excess. Statistical
errors due to uncertain coupling constants of the density functional are found
to be larger than systematic errors, the latter not exceeding 0.06 fm in most
neutron-rich nuclei across the nuclear landscape. The single major source of
uncertainty is the poorly determined slope L of the symmetry energy that
parametrizes its density dependence. Conclusions: To provide essential
constraints on the symmetry energy of the nuclear energy density functional,
next-generation measurements of neutron skins are required to deliver precision
better than 0.06 fm.Comment: 5 pages, 4 figure
Effect of disorder with long-range correlation on transport in graphene nanoribbon
Transport in disordered armchair graphene nanoribbons (AGR) with long-range
correlation between quantum wire contact is investigated by transfer matrix
combined with Landauer's formula. Metal-insulator transition is induced by
disorder in neutral AGR. Thereinto, the conductance is one conductance quantum
for metallic phase and exponentially decays otherwise when the length of AGR is
infinity and far longer than its width. Similar to the case of long-range
disorder, the conductance of neutral AGR first increases and then decreases
while the conductance of doped AGR monotonically decreases, as the disorder
strength increases. In the presence of strong disorder, the conductivity
depends monotonically and non-monotonically on the aspect ratio for heavily
doped and slightly doped AGR respectively.Comment: 6 pages, 8 figures; J. Phys: Condensed Matter (May 2012
Low temperature terahertz spectroscopy of n-InSb through a magnetic field driven metal-insulator transition
We use fiber-coupled photoconductive emitters and detectors to perform
terahertz (THz) spectroscopy of lightly-doped n-InSb directly in the cryogenic
(1.5 K) bore of a high-field superconducting magnet. We measure transmission
spectra from 0.1-1.1 THz as the sample is driven through a metal-insulator
transition (MIT) by applied magnetic field. In the low-field metallic state,
the data directly reveal the plasma edge and magneto-plasmon modes. With
increasing field, a surprisingly broad band (0.3-0.8 THz) of low transmission
appears at the onset of the MIT. This band subsequently collapses and evolves
into the sharp 1s -> 2p- transition of electrons `frozen' onto isolated donors
in the insulating state.Comment: 4 pages, 3 figure
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Assessment of dynamic closure for premixed combustion large eddy simulation
Turbulent piloted Bunsen flames of stoichiometric methane-air mixture are computed using LES paradigm involving an algebraic closure for the filtered reaction rate. This closure involves filtered scalar dissipation rate of a reaction progress variable. The model for this dissipation rate involves a parameter, !c, representing the flame front curvature effects induced by turbulence, chemical reactions, molecular dissipation, and their interactions at sub-grid level, suggesting that this parameter may vary with filter width or be a scale-dependent. Thus, it would be ideal to evaluate this parameter dynamically in LES. A procedure for this evaluation is discussed and assessed using DNS data and LES calculations. The probability density function of !c obtained from the DNS and LES calculations are very similar when the turbulent Reynolds number is sufficiently large and the filter width normalised by the laminar flame thermal thickness is larger than unity. Results obtained using a constant (static) value for this parameter are also used for comparative evaluation. Detailed discussion presented in this paper suggests that the dynamic procedure works well and physical insights and reasonings are provided to explain the observed behaviour.This work was supported by the EPSRC, Siemens and Rolls-Royce.This is the final version of the article. It first appeared from Taylor & Francis via http://dx.doi.org/10.1080/13647830.2015.108038
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