catena-Poly[[(5-bromopyridine-3-carbox­yl­ato)dimetyltin(IV)]-μ-5-bromopyridine-3-carboxyl­ato]

The title compound, [Sn(CH3)2(C6H3BrNO2)2], possesses an infinite chain structure owing to the presence of Sn—N bridges between adjacent mol­ecules. The SnO4NC2 centre has a distorted penta­gonal–bipyramidal geometry with the C atoms in the axial positions

Tetra­kis(μ2-5-methyl­pyrazine-2-carboxyl­ato)-1:2κ3 N 1,O:O;2:3κ3 O:N 1,O;1:2κ2 O:O′;3:4κ2 O:O′-octa­octyl-1κ2 C,2κ2 C,3κ2 C,4κ2 C-di-μ3-oxido-1:2:3κ3 O;1:3:4κ3 O-tetra­tin(IV)

The title compound, [Sn4(C8H17)8O2(C6H5N2O2)4], is a tetra­nuclear SnIV complex, built up by inversion symmetry around the central Sn2O2 ring. The SnIV coordination geometries are distorted SnO3C2 trigonal-bipyramidal and distorted SnO4C2 octa­hedral. The three-coordinate μ3-oxido bridging O atom in the Sn2O2 ring is attached to three Sn atoms. All non-H atoms, with the exception of the Sn-bonded octyl groups, lie approximately on a non-crystallographic mirror plane

Aquadi-n-but­yl(5-methyl­pyrazine-2-carboxyl­ato)tin(IV) methanol solvate

In the monomeric title compound, [Sn(C4H9)2(C6H5N2O2)2(H2O)]·CH3OH, the Sn atom is seven-coordinate, displaying a distorted penta­gonal bipyramidal SnC2N2O3 geometry with the two C atoms in the axial sites. In the crystal structure, inter­molecular O—H⋯O hydrogen bonds link the complex and solvent mol­ecules into infinite chains

Bis(2,2′-bipyridine-κ2 N,N′)chloridocobalt(II) perchlorate

In the cation of the title compound, [CoCl(C10H8N2)2]ClO4, the CoII atom displays a distorted trigonal-bipyramidal coordination geometry. The two pyridine rings in each 2,2′-bipyridine ligand form dihedral angles of 10.75 (12) and 4.28 (13)°. The crystal packing is stabilized by inter­ionic C—H⋯O hydrogen bonds, C—H⋯π inter­actions and aromatic π–π stacking inter­actions, with centroid–centroid distances of 3.616 (7) Å

Bis(2,2′-bipyridine)bis­{μ3-cis-N-(2-carboxyl­atophen­yl)-N′-[3-(dimethyl­amino)prop­yl]oxamidato(3−)}­bis(per­chlorato)­tetra­nickel(II) methanol disolvate

In the title methanol disolvate complex, [Ni4(C14H16N3O4)2(ClO4)2(C10H8N2)2]·2CH3OH, the neutral tetra­nickel(II) system lies on a centre of inversion. The polyhedron around each Ni(II) atom is a square pyramid. The separations of the Ni atoms bridged by the oxamide and carboxyl groups are 5.227 (9) and 5.268 (6) Å, respectively. In the crystal structure, a two-dimensional supramolecular network structure involving O—H⋯O and C—H⋯O hydrogen bonding is observed

Bis(5-methyl­pyrazine-2-carboxyl­ato)­diphenyl­tin(IV)

In the mol­ecule of the title compound, [Sn(C6H5)2(C6H5N2O2)2], two O and one N atoms from the two 5-methyl­pyrazine-2-carboxyl­ate ligands and one C atom of a phenyl group form a distorted square-planar arrangement in the equatorial plane around the Sn atom, while the distorted octa­hedral coordination is completed by an N atom of one of the 5-methyl­pyrazine-2-carboxyl­ate ligands and a C atom of the other phenyl group in the axial positions. In the crystal structure, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers

[N′-(3-Meth­oxy-2-oxidobenzyl­idene)nicotinohydrazidato]diphenyl­tin(IV)

The asymmetric unit of the title compound, [Sn(C6H5)2(C14H11N3O3)], contains two crystallographically independent mol­ecules that differ predominantly in the torsion of the phenyl rings. In both mol­ecules, the SnIV ion is in a distored trigonal-bipyramidal geometry. The Sn—O distances are in the range 2.055 (2)–2.143 (2) Å

[N′-(3-Meth­oxy-2-oxidobenzyl­idene)nicotinohydrazidato]dimethyl­tin(IV)

In the title complex, [Sn(CH3)2(C14H11N3O3)], the Sn atom is in a distorted trigonal-bipyramidal coordination, with Sn—O distances of 2.138 (2) and 2.176 (2) Å. The dihedral angles between the two chelated benzene rings and the O—Sn—N group are 71.73 (9) and 83.30 (9)°

Aqua­{μ-N-[3-(dimethyl­amino)­prop­yl]-N′-(2-oxidophen­yl)oxamidato(3−)}(1,10-phenanthroline)dicopper(II) nitrate

The title complex, [Cu2(C13H16N3O3)(C12H8N2)(H2O)]NO3, consists of a nitrate ion and a binuclear CuII unit in which the oxamide ligand has a cis geometry, is fully deprotonated and acts in a bidentate fashion to one CuII atom and in a tetradentate fashion to the other CuII atom. The CuII atom coordination geometries are distorted square-planar and distorted square-pyramidal. In the crystal structure, binuclear complexes and nitrate ions are connected by classical O—H⋯O and non-classical C—H⋯O hydrogen bonds into a three-dimensional framework. The alkyl chains of the anion are equally disorded over two positions

MicroRNAs Differentially Expressed in Postnatal Aortic Development Downregulate Elastin via 3′ UTR and Coding-Sequence Binding Sites

Elastin production is characteristically turned off during the maturation of elastin-rich organs such as the aorta. MicroRNAs (miRNAs) are small regulatory RNAs that down-regulate target mRNAs by binding to miRNA regulatory elements (MREs) typically located in the 3′ UTR. Here we show a striking up-regulation of miR-29 and miR-15 family miRNAs during murine aortic development with commensurate down-regulation of targets including elastin and other extracellular matrix (ECM) genes. There were a total of 14 MREs for miR-29 in the coding sequences (CDS) and 3′ UTR of elastin, which was highly significant, and up to 22 miR-29 MREs were found in the CDS of multiple ECM genes including several collagens. This overrepresentation was conserved throughout mammalian evolution. Luciferase reporter assays showed synergistic effects of miR-29 and miR-15 family miRNAs on 3′ UTR and coding-sequence elastin constructs. Our results demonstrate that multiple miR-29 and miR-15 family MREs are characteristic for some ECM genes and suggest that miR-29 and miR-15 family miRNAs are involved in the down-regulation of elastin in the adult aorta