2-Amino-4-[1-(2-chloro­phen­yl)-5-methyl-1H-1,2,3-triazol-4-yl]-6-(4-methyl­phen­yl)benzene-1,3-dicarbonitrile

In the title compound, C24H17ClN6, the dihedral angles between the triazolyl ring and its adjacent chlorobenzene and trisubstituted benzene rings are 90.6 (2) and 55.7 (3)°, respectively. The dihedral angle between the trisubstituted ring and the attached tolyl ring of the biphenyl unit is 45.9 (3)°. Intra- and intermolecular N—H⋯N hydrogen bonds are present

Wavelet multiresolution complex network for analyzing multivariate nonlinear time series

Z. K. Gao was supported by National Natural Science Foundation of China under Grant No. 61473203, and the Natural Science Foundation of Tianjin, China under Grant No. 16JCYBJC18200Peer reviewedPostprin

RNA sequencing analysis to capture the transcriptome landscape during skin ulceration syndrome progression in sea cucumber Apostichopus japonicus

Complement and coagulation cascades pathways (tif). Red boxes represent up-regulated genes, and green boxes represent down-regulated genes. (TIF 627 kb

Analysis of bacterial diversity in two oil blocks from two low-permeability reservoirs with high salinities

The community diversities of two oil reservoirs with low permeability of 1.81 x 10 \u273 and 2.29 x 10 \u273 1/4m 2 in Changqing, China, were investigated using a high throughput sequencing technique to analyze the influence of biostimulation with a nutrient activator on the bacterial communities. These two blocks differed significantly in salinity (average 17,500 vs 40,900 mg/L). A core simulation test was used to evaluate the effectiveness of indigenous microbial-enhanced oil recovery (MEOR). The results indicated that in the two high salinity oil reservoirs, one reservoir having relatively lower salinity level and a narrow salinity range had higher bacterial and phylogenetic diversity. The addition of the nutrient activator increased the diversity of the bacterial community structure and the diversity differences between the two blocks. The results of the core simulation test showed that the bacterial community in the reservoir with a salinity level of 17,500 mg/L did not show significant higher MEOR efficiency compared with the reservoir with 40,900 mg/L i.e. MEOR efficiency of 8.12% vs 6.56% (test p = 0.291 \u3e 0.05). Therefore, salinity levels affected the bacterial diversities in the two low permeability oil blocks remarkably. But the influence of salinity for the MEOR recovery was slightly

Case report: Gene mutation analysis and skin imaging of isolated café-au-lait macules

Background: Café-au-lait macules (CALMs) are common birthmarks associated with several genetic syndromes, such as neurofibromatosis type 1 (NF1). Isolated CALMs are defined as multiple café-au-lait macules in patients without any other sign of NF1. Typical CALMs can have predictive significance for NF1, and non-invasive techniques can provide more accurate results for judging whether café-au-lait spots are typical.Objectives: The study aimed to investigate gene mutations in six Chinese Han pedigrees of isolated CALMs and summarize the characteristics of CALMs under dermoscopy and reflectance confocal microscopy (RCM).Methods: In this study, we used Sanger sequencing to test for genetic mutations in six families and whole exome sequencing (WES) in two families. We used dermoscopy and RCM to describe the imaging characteristics of CALMs.Results: In this study, we tested six families for genetic mutations, and two mutations were identified as novel mutations. The first family identified [NC_000017.11(NM_001042492.2):c.7355G>A]. The second family identified [NC_000017.11(NM_001042492.2):c.2739_2740del]. According to genotype-phenotype correlation analyses, proband with frameshift mutation tended to have a larger number of CALMs and a higher rate of having atypical CALMs. Dermoscopy showed uniform and consistent tan-pigmented network patches with poorly defined margins with a lighter color around the hair follicles. Under RCM, the appearance of NF1 comprised the increased pigment granules in the basal layer and significantly increased refraction.Conclusion: A new heterozygous mutation and a new frameshift mutation of NF1 were reported. This article can assist in summarizing the properties of dermoscopy and RCM with CALMs

Impact of parental smoking on adipokine profiles and cardiometabolic risk factors in Chinese children

Acknowledgments We thank Prof. Jie Miandall, the BCAMS study members,and all participants for their continuing support with this research effort. Financial support This work was supported by National Key Research program of China (2016YFC1304801),key program of Beijing Municipal Science & Technology Commission (D111100000611001, D111100000611002), Beijing Natural Science Foundation (7172169), Beijing Science & Technology Star Program (2004A027), Novo Nordisk Union Diabetes Research Talent Fund (2011A002), National Key Program of Clinical Science (WBYZ2011-873), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2017PT32020, 2018PT32001) and Jingxi Scientific Program of Beijing Chaoyang Hospital (JXPY201606).Peer reviewedPublisher PD