RECIPE SUGGESTION TOOL

ABSTRACTThere is currently a great need for a tool to search cooking recipes based on ingredients. Current search engines do not provide this feature. Most of the recipe search results in current websites are not efficiently clustered based on relevance or categories resulting in a user getting lost in the huge search results presented.Clustering in information retrieval is used for higher efficiency and better presentation of information to the user. Clustering puts similar documents in the same cluster. If a document is relevant to a query, then the documents in the same cluster are also relevant.The goal of this project is to implement clustering on recipes. The user can search for recipes based on ingredient

Placental angiogenesis and immune-privilege in normal and pathological pregnancies

Ph.DDOCTOR OF PHILOSOPH

The Effects of Exosomal Derived TSG-6 on Microglia Activation

Following a traumatic brain injury, microglia become overactive for long periods and display pathologic behavior. We have shown that concentrated conditioned media from adipose tissue-derived mesenchymal stem cells (MSC-CCM) can suppress microglial activation. In this pilot study, we evaluated the efficacy of exosomes containing TNF-stimulated gene 6 (TSG6) derived from MSC-CCM on decreasing microglial activation in vitro via phagocytic activity and pro-inflammatory microglial gene expression

System-Level Access to On-Chip Instruments

Modern integrated circuits (ICs) contain thousands of instruments to enable testing, tuning, monitoring, and so on. These on-chip instruments must be accessed through the ICs’ life- time. However, when ICs are mounted on Printed Circuit Boards (PCBs), access from system-level is challenged due to complex system hierarchies with a multitude of interfaces. In this paper we enable access from system-level to chip-level instruments by proposing hardware, protocol, and communication schemes. We have validated our scheme by implementing a system with two ICs on a Field-Programmable Gate Array (FPGA) where each IC includes an IEEE Std. 1687 network, communication between ICs is with Serial Peripheral Interface (SPI) and communication with the outside is with Universal Asynchronous Receiver Transmitter (UART). In experiments we evaluate communication based on software (polling) and hardware (interrupt) as well as overhead in terms of transported data and needed area

Machine-to-machine communication for automatic retrieval of scientific data

Indiana University-Purdue University Indianapolis (IUPUI)With the increasing need for accurate weather predictions, we need large samples of data from different data sources for an accurate estimate. There are a number of data sources that keep publishing data periodically. These data sources have their own server protocols that a user needs to follow while writing client for retrieving data. This project aims at creating a generic semi-automatic client mechanism for retrieving scientific data from such sources. Also, with the increasing number of data sources there is also a need for a data model to accommodate data that is published in different formats. We have come up with a data model that can be used across various applications in the domain of scientific data retrieval

Scenario of ovarian mass lesions at a teaching hospital in Andhra Pradesh, India

Background: Ovary is the common site of non-neoplastic and neoplastic lesions which accounts for significant morbidity and mortality. The objective of present study was to ascertain the frequency and distribution of the various non-neoplastic and neoplastic ovarian mass lesions and to study the clinical and histopathological presentation.Methods: Observational study of cases with ovarian mass lesions subjected to surgical management from September 2009-August 2014 at our centre Government General Hospital/RMC Kakinada.Results: Incidence of ovarian masses was (n=404) 4.66% in 8,656 admissions subjected to surgical management. There were (340/404) 84.16% neoplasms and (64/404) 15.84% nonneoplastic lesions. Follicular and simple serous cysts were common non neoplastic lesions. Twisted ovarian cyst was the commonest surgical emergency. Age of the patients ranged from 9years to 82years.Mean ages of non-neoplastic, benign and malignant lesions were 34.2years, 36.8years and 44.7yrs.Most of the cases were in reproductive agegroup (p<0.001). Benign neoplasms were (248/340) 72.94%, borderline (26/340) 7.64% and malignant neoplasms were (66/340) 19.41%. Surface epithelial tumours dominated other types (78.12%) followed by germ cell tumours (12.05%) and sex cord stromal tumours (6.47%). Mucinous cystadenoma (34.11%) was the commonest benign tumour, followed by serouscystadenoma 23.53%. Commonest malignant ovarian tumour was serous cystadenocarcinoma (9.11%).Conclusion: Ovarian neoplasms were more common than non-neoplasms subjected to surgical management. Surface epithelial tumours were the commonest neoplasms with more benign neoplasms. Commonest benign neoplasm was mucinous cystadenoma and malignant was serous cystadenocarcinoma. Significant number of malignant ovarian tumors presented at an earlier age and in late stages

WSSL: Weighted Self-supervised Learning Framework For Image-inpainting

Image inpainting is the process of regenerating lost parts of the image. Supervised algorithm-based methods have shown excellent results but have two significant drawbacks. They do not perform well when tested with unseen data. They fail to capture the global context of the image, resulting in a visually unappealing result. We propose a novel self-supervised learning framework for image-inpainting: Weighted Self-Supervised Learning (WSSL) to tackle these problems. We designed WSSL to learn features from multiple weighted pretext tasks. These features are then utilized for the downstream task, image-inpainting. To improve the performance of our framework and produce more visually appealing images, we also present a novel loss function for image inpainting. The loss function takes advantage of both reconstruction loss and perceptual loss functions to regenerate the image. Our experimentation shows WSSL outperforms previous methods, and our loss function helps produce better results.Comment: 9 Pages, document submitted for publication at CGVCVIP 202

ANTICOAGULANT AND ANTIPLATELET ACTIVITIES OF JACKFRUIT (ARTOCARPUS HETEROPHYLLUS) SEED EXTRACT

  Objective: The current study focuses on the anticoagulant and antiplatelet activities of aqueous seed extract of Jackfruit (AqSEJ).Methods: Anticoagulant effect of AqSEJ was tested using plasma recalcification time, mouse tail bleeding time, Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT). Antiplatelet activity was examined by platelet aggregation studies using agonists such as ADP, Collagen and Epinephrine.Results: The AqSEJ enhanced the clotting time of citrated human plasma from control 200±10 s to 740±14 s. The anticoagulant activity of AqSEJ was further strengthened by in-vivo mouse tail bleeding assay. The i. v. injection of AqSEJ significantly prolonged the bleeding time in a dose dependent manner. The recorded bleeding time was&gt;10 min (P&lt;0.01) at the concentration of 30 μg against the PBS treated control of 1.48±0.10 min with the IC50 values 37.5 μg/ml and 47.5 μg/ml respectively. Interestingly, AqSEJ specifically prolonged the clot formation process of only APTT but not PT, revealing the anticoagulation triggered by the extract could be due to its interference in an intrinsic pathway of the blood coagulation cascade. Furthermore, AqSEJ inhibited the agonists such as ADP, epinephrine and collagen induced platelet aggregation of about 66.7%, 39.2% and 37.0% respectively at the concentration of 200 μg.Conclusion: AqSEJ showed anticoagulant and antiplatelet activities. Hence, it may serve as a better alternative for thrombotic disorders.Â

Imaging Mass Spectrometry Detection of Gangliosides Species Within the Mouse Brain Following Transient Focal Cerebral Ischemia

Gangliosides, a member of the glycosphingolipid family, are heterogeneously expressed in biological membranes and are particularly enriched within the central nervous system. Gangliosides consist of mono- or poly-sialylated oligosaccharide chains of variable lengths attached to a ceramide unit and are found to be intimately involved in brain disease development. The purpose of this study is to examine the spatial profile of ganglioside species using matrix-assisted laser desorption/ionization (MALDI) imaging (IMS) following middle cerebral artery occlusion (MCAO) reperfusion injury in the mouse. IMS is a powerful method to not only discriminate gangliosides by their oligosaccharide components, but also by their carbon length within their sphingosine base. Mice were subjected to a 30 min unilateral MCAO followed by long-term survival (up to 28 days of reperfusion). Brain sections were sprayed with the matrix 5-Chloro-2-mercaptobenzothiazole, scanned and analyzed for a series of ganglioside molecules using an Applied Biosystems 4800 MALDI TOF/TOF. Traditional histological and immunofluorescence techniques were performed to assess brain tissue damage and verification of the expression of gangliosides of interest. Results revealed a unique anatomical profile of GM1, GD1 and GT1b (d18∶1, d20∶1 as well as other members of the glycosphingolipid family). There was marked variability in the ratio of expression between ipsilateral and contralateral cortices for the various detected ganglioside species following MCAO-reperfusion injury. Most interestingly, MCAO resulted in the transient induction of both GM2 and GM3 signals within the ipsilateral hemisphere; at the border of the infarcted tissue. Taken together, the data suggest that brain region specific expression of gangliosides, particularly with respect to hydrocarbon length, may play a role in neuronal responses to injury

Yeast Isw1p forms two separable complexes in vivo - Supplementary Materials Only

There are several classes of ATP-dependent chromatin remodeling complexes, which modulate the structure of chromatin to regulate a variety of cellular processes. The budding yeast, Saccharomyces cerevisiae, encodes two ATPases of the ISWI class, Isw1p and Isw2p. Previously Isw1p was shown to copurify with three other proteins. Here we identify these associated proteins and show that Isw1p forms two separable complexes in vivo (designated Isw1a and Isw1b). Biochemical assays revealed that while both have equivalent nucleosome-stimulated ATPase activities, Isw1a and Isw1b differ in their abilities to bind to DNA and nucleosomal substrates, which possibly accounts for differences in specific activities in nucleosomal spacing and sliding. In vivo, the two Isw1 complexes have overlapping functions in transcriptional regulation of some genes yet distinct functions at others. In addition, these complexes show different contributions to cell growth at elevated temperatures