pediatric asthma and nephrolithiasis

asthma stone dat

Co-Occurrence of Asthma and Nephrolithiasis in Children.

It has been proposed that epithelial dysfunction and inflammation may predispose patients to kidney stone formation. Asthma is another chronic condition related to epithelial dysfunction and inflammation. We hypothesized that pediatric patients with asthma would have an increased prevalence of nephrolithiasis. Furthermore, we investigated if asthma patients with nephrolithiasis have clinical characteristics and urine profiles that point to mechanisms of stone formation. We evaluated 865 pediatric patients who had a diagnosis of nephrolithiasis. Clinical/demographic data and 24 hour urine samples were compared between asthma + stone (n = 142) and stone only patients. Data from asthmatics without stone were also available for evaluation of medication differences among asthma + stone and asthma only patients. The prevalence of nephrolithiasis in the pediatric population at our institution was 0.08% vs. 0.31% in our pediatric asthmatic population. The prevalence of asthma in our pediatric population was 6.8% vs. 26.7% in our pediatric stone patients. Asthma + stone patients were more likely to be on a combination inhaled corticosteroid + long acting beta agonist inhaler as compared to age/gender/BMI matched asthma patients without stone (29.7% vs. 13.7%, p = 0.0012). 259 kidney stone patients had 24 hour urine samples for comparison. There was no difference in 24 hour urine profiles between asthma + stone and stone only patients. Children with asthma have a 4-fold greater prevalence of kidney stones than the general pediatric population. Similarly, children with kidney stones have a 4-fold greater prevalence of asthma. This correlation may suggest a mechanistic link between asthma and nephrolithiasis. Further investigation is needed to elucidate the pathophysiologic origin of this relationship

Co-Occurrence of Asthma and Nephrolithiasis in Children.

It has been proposed that epithelial dysfunction and inflammation may predispose patients to kidney stone formation. Asthma is another chronic condition related to epithelial dysfunction and inflammation. We hypothesized that pediatric patients with asthma would have an increased prevalence of nephrolithiasis. Furthermore, we investigated if asthma patients with nephrolithiasis have clinical characteristics and urine profiles that point to mechanisms of stone formation. We evaluated 865 pediatric patients who had a diagnosis of nephrolithiasis. Clinical/demographic data and 24 hour urine samples were compared between asthma + stone (n = 142) and stone only patients. Data from asthmatics without stone were also available for evaluation of medication differences among asthma + stone and asthma only patients. The prevalence of nephrolithiasis in the pediatric population at our institution was 0.08% vs. 0.31% in our pediatric asthmatic population. The prevalence of asthma in our pediatric population was 6.8% vs. 26.7% in our pediatric stone patients. Asthma + stone patients were more likely to be on a combination inhaled corticosteroid + long acting beta agonist inhaler as compared to age/gender/BMI matched asthma patients without stone (29.7% vs. 13.7%, p = 0.0012). 259 kidney stone patients had 24 hour urine samples for comparison. There was no difference in 24 hour urine profiles between asthma + stone and stone only patients. Children with asthma have a 4-fold greater prevalence of kidney stones than the general pediatric population. Similarly, children with kidney stones have a 4-fold greater prevalence of asthma. This correlation may suggest a mechanistic link between asthma and nephrolithiasis. Further investigation is needed to elucidate the pathophysiologic origin of this relationship

Micro-Raman spectroscopy of mixed cancer cell populations

Micro-Raman spectroscopy was used to investigate randomly mixed cell populations of human promyelocytic leukemia (HL60) and human breast cancer (MCF7); human uterine sarcoma (Mes-sa) and MCF7; as well as their respective pure cell lines. In this study the efficiency of micro-Raman spectroscopy to identify a cell type in randomly distributed mixed cell population was assessed. Raman data show that the differences in spectral profile between MCF7 and HL60 cell lines were more marked than those between MCF7 and Mes-sa cells. This shows that cells from different origins can display variances in their spectral signatures. Spectra were also analyzed by principal components analysis and results obtained from pure cell populations gave a reasonably good delineation between the cell types. Analysis of both mixed cell populations along with their pure cells counterparts, resulted in each case in three different clusters corresponding to the two pure cell populations and the mixed populations. However, a few spectra from the mixed population remained misclassified and were found to be closer to the clusters corresponding to pure cells. These results indicate that micro-Raman spectroscopy can be used to identify a cell type in a mixed cell population via its spectral signature

The prevalence of nephrolithiasis at our institution in all children and children with asthma.

<p>The prevalence of nephrolithiasis at our institution in all children and children with asthma.</p

Clinical-Demographic data for current pediatric patients stratified by asthma and kidney stone diagnosis.

<p>Clinical-Demographic data for current pediatric patients stratified by asthma and kidney stone diagnosis.</p