10 research outputs found
Expedient synthesis of tetrasubstituted pyrroles via a copper-catalyzed cascade inter-/intramolecular cyclization of 1,3-enynes carry a nitro group with amines
Various tetrasubstituted pyrroles/pyrazoles have been prepared from nitro-substituted 1,3-enynes with aromatic amines/hydrazines via a copper-catalyzed cascade aza-Michael addition, cyclization and aromatization at room temperature. This protocol is also effective for the synthesis of tetrasubstituted pyrazoles in high yields
A novel tandem sequence to pyrrole syntheses by 5-endo-digcyclization of 1,3-enynes with amines
The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions
Domino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with Mercaptoacetaldehyde
Domino
synthesis of tetrasubstituted thiophenes is described from
1,3-enynes and mercaptoacetaldehyde using DABCO at room temperature
via a Michael addition, 5-exo-dig carboannulation, and oxidation sequence
under air. The broad substrate scope and mild reaction conditions
are significant practical features
Domino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with Mercaptoacetaldehyde
Domino
synthesis of tetrasubstituted thiophenes is described from
1,3-enynes and mercaptoacetaldehyde using DABCO at room temperature
via a Michael addition, 5-exo-dig carboannulation, and oxidation sequence
under air. The broad substrate scope and mild reaction conditions
are significant practical features
A Novel Tandem Sequence to Pyrrole Syntheses by 5-<i>endo</i>-<i>dig</i> Cyclization of 1,3-Enynes with Amines
The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions
A Novel Tandem Sequence to Pyrrole Syntheses by 5-<i>endo</i>-<i>dig</i> Cyclization of 1,3-Enynes with Amines
The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions