A Novel Tandem Sequence to Pyrrole Syntheses by 5-<i>endo</i>-<i>dig</i> Cyclization of 1,3-Enynes with Amines

Abstract

The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions