On the Use of Low-Z Targets in Space-Based Hadron Calorimetry

Abstract In space-based experiments, detector mass is a critical concern. To allow an acceptable geometric acceptance, calorimeters used in such situations must be thin, and will thus not fully contain hadron showers. We discuss the benefits of using a low-Z target in front of thin calorimeters to force nuclear interactions and improve resolution. We report simulation results comparing several target options and a 'monolithic' configuration. The results demonstrate how calorimeter configuration, available mass, required energy resolution and 'good event' definitions can affect the optimal division of mass between the target and the calorimeter. Finally we suggest a method to optimize design choices based on the parameters of the experiment

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Few studies have explored the impact of rare variants (minor allele frequency \u3c 1%) on highly heritable plasma metabolites identified in metabolomic screens. The Finnish population provides an ideal opportunity for such explorations, given the multiple bottlenecks and expansions that have shaped its history, and the enrichment for many otherwise rare alleles that has resulted. Here, we report genetic associations for 1391 plasma metabolites in 6136 men from the late-settlement region of Finland. We identify 303 novel association signals, more than one third at variants rare or enriched in Finns. Many of these signals identify genes not previously implicated in metabolite genome-wide association studies and suggest mechanisms for diseases and disease-related traits

Relative abundances of cosmic ray nuclei B-C-N-O in the energy region from 10 GeV/n to 300 GeV/n. Results from ATIC-2 (the science flight of ATIC)

The ATIC balloon-borne experiment measures the energy spectra of elements from H to Fe in primary cosmic rays from about 100 GeV to 100 TeV. ATIC is comprised of a fully active bismuth germanate calorimeter, a carbon target with embedded scintillator hodoscopes, and a silicon matrix that is used as the main charge detector. The silicon matrix produces good charge resolution for protons and helium but only partial resolution for heavier nuclei. In the present paper, the charge resolution of ATIC was improved and backgrounds were reduced in the region from Be to Si by using the upper layer of the scintillator hodoscope as an additional charge detector. The flux ratios of nuclei B/C, C/O, N/O in the energy region from about 10 GeV/nucleon to 300 GeV/nucleon obtained from this high-resolution, high-quality charge spectra are presented, and compared with existing theoretical predictions.Comment: 4 pages,2 figures, a paper for 30-th International Cosmic Rays Conferenc

Simulation of the ATIC-2 Silicon Matrix for Protons and Helium GCR Primaries at 0.3, 10, and 25 TeV/Nucleon

The energy deposition distribution for protons and helium galactic cosmic ray primaries at 0.3, 10, and 25 TeV/nucleon in the ATIC-2 silicon matrix detector are simulated with GEANT4. The GEANT3 geometrical model of ATIC developed by the University of Maryland was combined with a GEANT4 application developed for the Deep Space Test Bed (DSTB) detector package. The new code included relatively minor modifications to completely describe the ATIC materials and a more detailed model of the Silicon Matrix detector. For this analysis all particles were started as a unidirectional beam at a single point near the center of the Silicon Matrix front surface. The point was selected such that each primary passed through at least two of the overlapping silicon pixels

Beam test calibration of the balloon-borne imaging calorimeter for the CREAM experiment

CREAM (Cosmic Ray Energetics And Mass) is a multi-flight balloon mission designed to collect direct data on the elemental composition and individual energy spectra of cosmic rays. Two instrument suites have been built to be flown alternately on a yearly base. The tungsten/Sci-Fi imaging calorimeter for the second flight, scheduled for December 2005, was calibrated with electron and proton beams at CERN. A calibration procedure based on the study of the longitudinal shower profile is described and preliminary results of the beam test are presented.Comment: 4 pages, 4 figures. To be published in the Proceedings of 29th International Cosmic Ray Conference (ICRC 2005), Pune, India, August 3-10, 200

A Detailed FLUKA-2005 Monte Carlo Simulation for the ATIC Detector

We have performed a detailed Monte Carlo (MC) calculation for the Advanced thin Ionization Calorimeter (ATIC) detector using the MC code FLUKA-2005 which is capable of simulating particles up to 10 PeV. The ATIC detector has completed two successful balloon flights from McMurdo, Antarctica lasting a total of more than 35 days. ATIC is designed as a multiple, long duration balloon Bight, investigation of the cosmic ray spectra from below 50 GeV to near 100 TeV total energy; using a fully active Bismuth Germanate @GO) calorimeter. It is equipped with a large mosaic of silicon detector pixels capable of charge identification and as a particle tracking system, three projective layers of x-y scintillator hodoscopes were employed, above, in the middle and below a 0.75 nuclear interaction length graphite target. Our calculations are part of an analysis package of both A- and energy-dependences of different nuclei interacting with the ATIC detector. The MC simulates the responses of different components of the detector such as the Simatrix, the scintillator hodoscopes and the BGO calorimeter to various nuclei. We also show comparisons of the FLUKA-2005 MC calculations with a GEANT calculation and data for protons, He and CNO

Cosmic-Ray Proton and Helium Spectra from the First CREAM Flight

Cosmic-ray proton and helium spectra have been measured with the balloon-borne Cosmic Ray Energetics And Mass experiment flown for 42 days in Antarctica in the 2004-2005 austral summer season. High-energy cosmic-ray data were collected at an average altitude of ~38.5 km with an average atmospheric overburden of ~3.9 g cm$^{-2}$. Individual elements are clearly separated with a charge resolution of ~0.15 e (in charge units) and ~0.2 e for protons and helium nuclei, respectively. The measured spectra at the top of the atmosphere are represented by power laws with a spectral index of -2.66 $\pm$ 0.02 for protons from 2.5 TeV to 250 TeV and -2.58 $\pm$ 0.02 for helium nuclei from 630 GeV/nucleon to 63 TeV/nucleon. They are harder than previous measurements at a few tens of GeV/nucleon. The helium flux is higher than that expected from the extrapolation of the power law fitted to the lower-energy data. The relative abundance of protons to helium nuclei is 9.1 $\pm$ 0.5 for the range from 2.5 TeV/nucleon to 63 TeV/nucleon. This ratio is considerably smaller than the previous measurements at a few tens of GeV/nucleon.Comment: 20 pages, 4 figure