4 research outputs found

    Extended-spectrum β-lactamase-producing Enterobacteriaceae in healthy companion animals living in nursing homes and in the community

    No full text
    Animals could be reservoirs of extended-spectrum β-lactamases (ESBL) strains, but epidemiologic data on ESBL-producing bacteria in healthy pets are missing. We determined the prevalence of ESBL-producing Enterobacteriaceae in pets living in nursing homes and in households to investigate the potential role of companion animals as carriers of ESBL.; Three hundred seventy-six rectal swabs were taken from cats and dogs visiting or living in 68 randomly selected nursing homes or brought to 26 veterinary practices in Switzerland for routine mandatory vaccination. Isolates were identified by matrix-assisted laser desorption ionization time of flight mass spectrometry. Confirmatory tests were performed on the isolated Enterobacteriaceae. Phenotypic ESBL isolates were investigated for genetic determinants of resistance.; The overall prevalence of ESBL isolates, adjusted for clustering, was 2.5% (95% confidence interval: 1.3-4.6). Pets that received an antibiotic treatment in the 3 months prior to the study had a higher risk to be carriers of these microorganisms (Adjusted odds ratio, 7.8; 95% confidence interval: 2.2-26.9).; ESBL-producing Enterobacteriaceae were present in healthy cats and dogs, particularly from those with a history of antibiotic treatment. These animals could become ESBL reservoirs. Investigations are needed to assess the possible transmission of these microorganisms between pets and humans

    Prevalence and risk factors for carriage of multi-drug resistant Staphylococci in healthy cats and dogs

    Get PDF
    We investigated the distribution of commensal staphylococcal species and determined the prevalence of multi-drug resistance in healthy cats and dogs. Risk factors associated with the carriage of multi-drug resistant strains were explored. Isolates from 256 dogs and 277 cats were identified at the species level using matrix-assisted laser desorption ionisation-time of flight mass spectrometry. The diversity of coagulase-negative Staphylococci (CNS) was high, with 22 species in dogs and 24 in cats. Multi-drug resistance was frequent (17%) and not always associated with the presence of the mecA gene. A stay in a veterinary clinic in the last year was associated with an increased risk of colonisation by multi-drug resistant Staphylococci (OR = 2.4, 95% CI: 1.1˜5.2, p value LRT = 0.04). When identifying efficient control strategies against antibiotic resistance, the presence of mechanisms other than methicillin resistance and the possible role of CNS in the spread of resistance determinants should be considered

    Beneficial Effects of a Semi-Intensive Stroke Unit are Beyond the Monitor.

    Get PDF
    BACKGROUND AND PURPOSE Precise mechanisms underlying the effectiveness of the stroke unit (SU) are not fully established. Studies that compare monitored stroke units (semi-intensive type, SI-SU) versus an intensive care unit (ICU)-based mobile stroke team (MST-ICU) are lacking. Although inequalities in access to stroke unit care are globally improving, acute stroke patients may be admitted to Intensive Care Units for monitoring and followed by a mobile stroke team in hospital's lacking an SU with continuous cardiovascular monitoring. We aimed at comparing the stroke outcome between SI-SU and MST-ICU and hypothesized that the benefits of SI-SU are driven by additional elements other than cardiovascular monitoring, which is equally offered in both care systems. METHODS In a single-center setting, we compared the unfavorable outcomes (dependency and mortality) at 3 months in consecutive patients with ischemic stroke or spontaneous intracerebral hemorrhage admitted to a stroke unit with semi-intensive monitoring (SI-SU) to a cohort of stroke patients hospitalized in an ICU and followed by a mobile stroke team (MST-ICU) during an equal observation period of 27 months. Secondary objectives included comparing mortality and the proportion of patients with excellent outcomes (modified Rankin Score (mRS) 0-1). Equal cardiovascular monitoring was offered in patients admitted in both SI-SU and MST-ICU. RESULTS 458 patients were treated in the SI-SU and compared to the MST-ICU (n = 370) cohort. The proportion of death and dependency after 3 months was significantly improved for patients in the SI-SU compared to MST-ICU (p < 0.001; aOR = 0.45; 95% CI: 0.31-0.65). The shift analysis of the mRS distribution showed significant shift to the lower mRS in the SI-SU group, p < 0.001. The proportion of mortality in patients after 3 months also differed between the MST-ICU and the SI-SU (p < 0.05), but after adjusting for confounders this association was not significant (aOR = 0.59; 95% CI: 0.31-1.13). The proportion of patients with excellent outcome was higher in the SI-SU (59.4 vs. 44.9%, p < 0.001) but the relationship was no more significant after adjustment (aOR = 1.17; 95% CI: 0.87-1.5). CONCLUSIONS Our study shows that moving from a stroke team in a monitored setting (ICU) to an organized stroke unit leads to a significant reduction in the 3 months unfavorable outcome in patients with an acute ischemic or hemorrhagic stroke. Cardiovascular monitoring is indispensable, but benefits of a semi-intensive Stroke Unit are driven by additional elements beyond intensive cardiovascular monitoring. This observation supports the ongoing development of Stroke Centers for efficient stroke care. © 2015 S. Karger AG, Basel
    corecore