Assessing tracheal health using optical metabolic imaging and optical coherence tomography

The health and pathophysiology of the tracheal mucosa is an important yet poorly understood aspect of respiratory medicine. Cilia, hair-like organelles important for mucociliary clearance, line the tracheal mucosa. Ciliary dysfunction leads to severe diseases such as primary ciliary dyskinesia and cystic fibrosis. Optical imaging can monitor ciliary function in vivo, ex vivo, and in vitro to understand the genesis of ciliary disease and potential treatment targets. Specifically, optical coherence tomography (OCT) has been used to quantify multiple parameters of ciliary motility in 2D and 3D. However, OCT inherently lacks information about the biochemical or metabolic state of cells. Optical metabolic imaging (OMI) quantitatively assesses cellular metabolism by imaging the autofluorescence intensities of endogenous metabolic co-enzymes nicotinamide dinucleotide (NADH) and flavin adenine dinucleotide (FAD). OMI probes the optical redox ratio (NADH intensity divided by FAD intensity), which is sensitive to the relative amounts of electron donors and acceptors within a cell. Ciliary function is highly dependent on ATP and therefore tightly linked to NADH and FAD levels through multiple metabolic pathways Please click Additional Files below to see the full abstract

Visualization 1: Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography

DPIV-based flow field reconstruction of flow phantom Originally published in Biomedical Optics Express on 01 September 2015 (boe-6-9-3515

All Day Breakfast, Reading International atMunchees

DPIV-based flow field reconstruction of CSF flow in ventricle Originally published in Biomedical Optics Express on 01 September 2015 (boe-6-9-3515

Quality of life in patients with denture

Autor: Lucie Rajmová, DiS Institution: Ústav sociálního lékařství LF UK v Hradci Králové, oddělení ošetřovatelství Title of the work: Kvalita života stomatologického pacienta se zubní náhradou Head of work: Prof. PhDr. Jiří Mareš, CSc. Number of pages: 77 Number of enclosures: 3 Year of vindication: 2011 Key words: quality of life, dentistry, denture This thesis deals with the quality of life for patients with denture. The theoretical part explains the concept of "quality of life" and mentions the specific methods used to evaluate the quality of life related to oral health. We can also focus on the distribution of dental restorations, proper care of dentures, nutritional problems in patients with denture, dental prostheses issues of intolerance, the importance of communication. The empirical part examines the quality of life in 100 outpatients with denture using OHIP questionnaire 20E. We conclude that the whole area is the worst experience of physical handicap. Other areas in which patients experience difficulties, including: functional limitations, physical pain and psychological discomfort. Less problematic are the other three areas: psychological disability and social disability, handicap