EVALUATION OF DIFFERENT SOURCES OF PHOSPHORUS ON PERFORMANCE AND BLOOD CHARACTERISTICS OF BROILER CHICKENS

This research was conducted to investigate the utilization of rock phosphate as an alternative phosphorus source in broiler diet. Rock phosphate is known to contain high amount of calcium and phosphorus, but its utilization has been limited due to its fluorine contents. A total of 250 Sayed broiler chicks were purchased at day old and brooded. After brooding, 210 very active and health chicks were allotted at random to 3 dietary treatments, each with 5 replicate pens such that 14 birds were assigned to each replicate and a total of 70 birds made up a treatment. The result showed that there were no significant (P >0.05) variations among all the parameters determined. Different sources of phosphorus did not show any significant difference (P>0.05) on performance of broiler at both starter (28 days of age) and finisher (56 days of age) among the dietary treatment groups for all parameters evaluated. Also, there were no significant (P >0.05) variations among all the blood parameters determined. Mean values of calcium obtained from blood serum of broiler finisher chickens in this study ranged between 2.38 mmol/l and 2.44 mmol/l (4.76 – 4.88 mEq/l or 9.52 – 9.76 mg/dl

Capacity Building for Primary Stroke Prevention Teams in Children Living With Sickle Cell Anemia in Africa

Background: Nigeria has the highest proportion of children with sickle cell anemia (SCA) globally; an estimated 150,000 infants with SCA are born annually. Primary stroke prevention in children with SCA must include Nigeria. We describe capacity-building strategies in conjunction with two National Institutes of Health–funded primary stroke prevention trials (a feasibility trial and phase III randomized controlled trial) with initial hydroxyurea treatment for children with SCA and abnormal transcranial Doppler (TCD) velocities in Nigeria. We anticipated challenges to conducting clinical trials in a low-resource setting with a local team that had not previously been involved in clinical research and sought a sustainable strategy for primary stroke prevention. Methods: This is a descriptive, prospective study of challenges, solutions, and research teams in two trials that enrolled a total of 679 children with SCA. Results: As part of the capacity-building component of the trials, over eight years, 23 research personnel (physicians, nurses, research coordinators, a statistician, and a pharmacist) completed a one-month research governance and ethics training program at Vanderbilt University Medical Center, USA. A lead research coordinator for each site completed the Society of Clinical Research Professionals certification. TCD machines were donated; radiologists and nonradiologists were trained and certified to perform TCD. A scalable E-prescription was implemented to track hydroxyurea treatment. We worked with regional government officials to support ongoing TCD-based screening and funding for hydroxyurea for children with SCA at a high risk of stroke. Conclusions: Our trials and capacity building demonstrate a sustainable strategy to initiate and maintain pediatric SCA primary stroke prevention programs in Africa

Circuit Modeling of Dual Band MIMO Diversity Antenna for LTE and X-Band Applications

This paper presents a study on developing a dual-band antenna equivalent circuit model for X-Band and LTE applications. MIMO antennas play a crucial role in modern wireless communication systems, and understanding their impedance behavior is essential. This work proposes a dual-band lumped equivalent circuit model, utilizing gradient optimization based on antenna-simulated S-parameters in Advanced Design System (ADS). The four radiating elements of the MIMO antenna are accurately modeled, considering their geometry and the defected ground structure (DGS) effect, which enhances the antenna's isolation and low correlation coefficient (ECC). The calculated lumped equivalent circuit model is validated through rigorous simulation and measurement data, demonstrating consistency with the expected results. The experimental measurements show measured isolation exceeding 20 dB while achieving a maximum realized gain of 5.9 dBi and an efficiency of 87%. The developed model holds promise for improving the design and performance of MIMO antennas for various applications

Molecular Characterization of Streptococcus Pneumoniae Causing Disease Among Children in Nigeria During the Introduction of PCV10 (GSK)

Streptococcus pneumoniae (pneumococcus) is a leading vaccine-preventable cause of childhood invasive disease. Nigeria has the second highest pneumococcal disease burden globally, with an estimated ~49 000 child deaths caused by pneumococcal infections each year. Ten-valent pneumococcal conjugate vaccine (GSK; PCV10) was introduced in December 2014 in a phased approach. However, few studies have characterized the disease-causing pneumococci from Nigeria. This study assessed the prevalence of serotypes, antibiotic susceptibility and genomic lineages using whole genome sequencing and identified lineages that could potentially escape PCV10 (GSK). We also investigated the potential differences in pneumococcal lineage features between children with and without sickle cell disease. A collection of 192 disease-causing pneumococcal isolates was obtained from Kano (n=189) and Abuja (n=3) states, Nigeria, between 1 January 2014 and 31 May 2018. The majority (99 %, 190/192) of specimens were recovered from children aged 5 years or under. Among them, 37 children had confirmed or traits of sickle cell disease. Our findings identified 25 serotypes expressed by 43 Global Pneumococcal Sequence Clusters (GPSCs) and 85 sequence types (STs). The most common serotypes were 14 (18 %, n=35), 6B (16 %, n=31), 1 (9 %, n=17), 5 (9 %, n=17) and 6A (9 %, n=17); all except serotype 6A are included in PCV10 (GSK). PCV10 (SII; PNEUMOSIL) and PCV13 formulations include serotypes 6A and 19A which would increase the overall coverage from 67 % by PCV10 (GSK) to 78 and 82 %, respectively. The pneumococcal lineages were a mix of globally spreading and unique local lineages. Following the use of PCV10 (GSK), GPSC5 expressing serotype 6A, GPSC10 (19A), GPSC26 (12F and 46) and GPSC627 (9L) are non-vaccine type lineages that could persist and potentially expand under vaccine-selective pressure. Approximately half (52 %, 99/192) of the pneumococcal isolates were resistant to the first-line antibiotic penicillin and 44 % (85/192) were multidrug-resistant. Erythromycin resistance was very low (2 %, 3/192). There was no significant difference in clinical manifestation, serotype prevalence or antibiotic resistance between children with and without traits of or confirmed sickle cell disease. In summary, our findings show that a high percentage of the pneumococcal disease were caused by the serotypes that are covered by currently available vaccines. Given the low prevalence of resistance, macrolide antibiotics, such as erythromycin, should be considered as an option to treat pneumococcal disease in Nigeria. However, appropriate use of macrolide antibiotics should be vigilantly monitored to prevent the potential increase in macrolide resistance

The non-zero divisor graph of ring of integers modulo six and the hamiltonian quaternion over integers modulo two

The study of graph theory was introduced and widely researched since many practical problems can be represented by graphs. A non-zero divisor graph is a graph in which its set of vertices is the non-zero elements of the ring and the vertices x and y are adjacent if and only if xy ≠ 0. In this study, we introduced the non-zero divisor graphs of some finite commutative rings in specific the ring of in tegers modulo 6, 6 and ring of Hamiltonian quaternion, (2). First, the non-zero divisors of the commutative rings are found. Then, the non-zero divisor graphs are constructed. Finally, some properties of the graph, including the chromatic number, clique number, girth and the diameter are obtained

The trend of collapse of buildings in concrete materials in Lagos State, Nigeria (2013-2019)

t. In recent times, efforts are channeled towards limiting the impact of waste plastic pollution on the environment. This study examines the beneficial utilization of polyethylene terephthalate (PET) wastes, which is a non-biodegradable waste materials as a partial substitute for sand in the production of non-load bearing hollow sandcrete blocks. The physical and mechanical properties such as density and compressive strength of the hollow sandcrete blocks using PET waste as a replacement for fine aggregate at 5%, 10%, 30% and 50% were determined. Tests results show that the density of the produced sandcrete blocks decreases as the waste PET content increases. Results showed that the density varied from 1391.33 kg/m3 for 50%PET content to 1954.54 kg/m3 for 5%PET content, while the density of the reference sandcrete was 2002.15 kg/m3 for 7 days. The values of densities ranged between 1453.88 kg/m3 for PET 50% and 1851.09 kg/m3 for PET 5% and the density of reference sandcrete was 1991.77 kg/m3 at 28 days. The sandcrete blocks also demonstrate a similar reduction trend in compressive strength as the PET content increases. The compressive strength ranged between 1.140 N/mm2 for 50%PET and 2.564 N/mm2 for 5%PET content and 1.510 N/mm2 for 50%PET to 2.991 N/mm2 for 5%PET respectively, as the curing age increases from 7 to 28 days. The hollow sandcrete block containing an optimum 5% replacement percentage of sand with PET waste showed comparable strength to the conventional sandcrete blocks. This will help to mitigate the menace of marine plastic pollution and promote responsible consumption

Development and feasibility testing of an animated cartoon-based self-care application for low-back pain – a pilot study

Objectives: The use of animated cartoons for pain management is an emerging area, however, in no study has it been explored as a digital platform for the rehabilitation of low-back pain (LBP). This study was aimed to develop and evaluate the feasibility of an animated cartoon-based self-care (ACBSC) app for LBP, and to examine the correlation between the app rating parameters and patients’ pain. Methods: This 2-phase study comprised development and feasibility testing components. Development of the ACBSC app was based on Mckenzie’s Mechanical Diagnosis and Therapy (MDT) extension protocol plus back hygiene following standard it-eration and prototyping process. Twenty-eight consecutive patients with chronic non-specific LBP with ‘direction Preference’ for extension based on the MDT screening algorithm participated in the feasibility phase. The participants utilised the car-toon-based app thrice weekly for 2 weeks. Outcomes were assessed in terms of usability, satisfaction and user experience ap-plying the system usability and mobile application rating scales. The Quadruple Visual Analogue Scale (QVAS) was used to assess the participants’ pain intensity. Results: On a unified scale up to 20, functionality (15.4 ± 2.41) and aesthetics 14 ± 2.00 had highest and least objective quality rating on the app parameters. Total objective and subjective quality rating of the app was 16.9 ± 1.97 and 15.6 ± 2.42, respectively. The total impact and usability scores were 24.1 ± 3.39 (out of 30) and 27.8 ± 3.09 (out of 50). Participants re-ported that the cartoon app for back care mostly affected mindfulness/meditation/relaxation (42.9%), increasing happiness/ well-being (46.4%), leading to behavioural changes (60.7%), while targeting physical health (100%). There was no significant correlation between participants’ pain characteristics and app rating parameters (p>0.05). Conclusion: The animated cartoon-based self-care LBP app has moderate to high usability, functionality, aesthetics and quality rating, and may serve as an effective mobile-app for self-management of long-term LBP

The trend of collapse of buildings in concrete materials in Lagos State, Nigeria (2013-2019)

Buildings are essential structures that provide mankind with accommodation in the form of offices, factories, residences, etc. Building Infrastructure aid to increase the Gross domestic product of nations by meeting the present needs as well as helping in the reduction of future deficiencies. Unfortunately, in developing countries like Nigeria, regular occurrence of collapse of buildings in concrete materials have dealt a terrible blow to the nation, leading to losses in the form of death and damage to properties. This study aims to show the trend within the period of 2013 to 2019. This study used statistical methods to assess the fatality rate, types of buildings affected, frequency of occurrences and the causative factors. The result indicates that the year2017 witnessed 14 collapse incidences making it the highest within the study period in Lagos state. Furthermore, 204 persons lost their lives in 2014, making it the highest within the period. The results obtained showed that the risk of collapse and fatality rises as the building height goes up and when unauthorized floors are added to an existing building

Comparison of Bacterial Culture With Biofire® Filmarray® Multiplex PCR Screening of Archived Cerebrospinal Fluid Specimens From Children With Suspected Bacterial Meningitis in Nigeria

BACKGROUND: Diagnosis of bacterial meningitis remains a challenge in most developing countries due to low yield from bacterial culture, widespread use of non-prescription antibiotics, and weak microbiology laboratories. The objective of this study was to compare the yield from standard bacterial culture with the multiplex nested PCR platform, the BioFire® FilmArray® Meningitis/Encephalitis Panel (BioFire ME Panel), for cases with suspected acute bacterial meningitis. METHODS: Following Gram stain and bacterial culture on cerebrospinal fluid (CSF) collected from children aged less than 5 years with a clinical suspicion of acute bacterial meningitis (ABM) as defined by the WHO guidelines, residual CSF specimens were frozen and later tested by BioFire ME Panel. RESULTS: A total of 400 samples were analyzed. Thirty-two [32/400 (8%)] of the specimens were culture positive, consisting of; three Salmonella spp. (2 Typhi and 1 non-typhi), three alpha hemolytic Streptococcus, one Staphylococcus aureus, six Neisseria meningitidis, seven Hemophilus influenzae, 11 Streptococcus pneumoniae and 368 were culture negative. Of the 368 culture-negative specimens, the BioFire ME Panel detected at least one bacterial pathogen in 90 (24.5%) samples, consisting of S. pneumoniae, N. meningitidis and H. influenzae, predominantly. All culture positive specimens for H. influenzae, N. meningitidis and S. pneumoniae also tested positive with the BioFire ME Panel. In addition, 12 specimens had mixed bacterial pathogens identified. For the first time in this setting, we have data on the viral agents associated with meningitis. Single viral agents were detected in 11 (2.8%) samples while co-detections with bacterial agents or other viruses occurred in 23 (5.8%) of the samples. CONCLUSIONS: The BioFire® ME Panel was more sensitive and rapid than culture for detecting bacterial pathogens in CSF. The BioFire® ME Panel also provided for the first time, the diagnosis of viral etiologic agents that are associated with meningoencephalitis in this setting. Institution of PCR diagnostics is recommended as a routine test for suspected cases of ABM to enhance early diagnosis and optimal treatment