13 research outputs found
Intérêt d'une radiothérapie pré-opératoire potentialisée par du 5 FU oral dans les cancers pancréatiques résecables
No full textLILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Patients opérés de la maladie de Crohn colique (quels éléments peuvent déterminer le choix d'une colectomie segmentaire ou d'une colectomie totale ?)
No full textLILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Survie après des résections des adénocarcinomes pancréatiques et péri ampullaires (mythe ou réalité ?)
No full textLILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Cholangiocarcinomes extra hépatiques (étude des modalités de prise en charge et révision des objectifs de traitement)
No full textLILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
L'anastomose iléorectale dans le traitement de la rectocolite ulcéro-hémorragique...40 ans après : faut-il la réhabiliter ou la condamner définitivement ?
No full textLILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Résultats fonctionnels et bilan nutritionnel et osseux six ans après la réalisation d'une anastomose iléo-anale chez des patients opérés de rectocolite hémorragique
No full textLILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
No full textInternational audienceBackground & Aims: Infectious agents are suspected of being involved in the pathogenesis of Crohn's disease. This study was designed to look for the presence of virulent Escherichia coli strains associated with the ileal mucosa of patients with Crohn's disease. Methods: E. coli strains were recovered from resected chronic ileal lesions (n = 20), neoterminal ileum after surgery from patients with (n = 19) and without (n = 11) endoscopic recurrence, and controls (n = 13). Bacterial adhesion was determined in vitro using intestinal cell lines; other associated virulence factors were assessed by DNA hybridization and polymerase chain reaction experiments. Results: None of the strains harbored any of the virulence factor–encoding genes of E. coli involved in acute enteric diseases. However, mannose-resistant adhesion to differentiated Caco-2 cells was found for 84.6% and 78.9% of the E. coli strains isolated from chronic and early recurrent lesions, respectively, compared with 33% of controls (P < 0.02). In addition, 21.8% of the strains induced a cytolytic effect by synthesis of an α-hemolysin. Conclusions: E. coli strains isolated from the ileal mucosa of patients with Crohn's disease adhere to differentiated intestinal cells and may disrupt the intestinal barrier by synthesizing an α-hemolysin
