11 research outputs found
The Glass Ceiling: Examining the Advancement of Women in the Domain of Athletic Administration
- Author
- Publication venue
- DigitalCommons@EMU
- Publication date
- 08/10/2012
- Field of study
The “glass ceiling” is a metaphor for examining gender disparities between men and women within the workplace. Such disparities are particularly visible in athletic administration. This literature review evaluates specific leadership characteristics and their relationship to gender stereotyping in Sport Management. Because athletic administration is a male dominated domain, there appears to be discrimination against women, creating a gender gap that prevents the advancement of women into top-level managerial positions
The glass ceiling: Examining leadership perceptions within the domain of athletic administration
- Author
- Publication venue
- DigitalCommons@EMU
- Publication date
- 01/01/2013
- Field of study
The glass ceiling is a metaphor for examining gender disparities between men and women within the workplace. The disparity is particularly dominate in the domain of athletic administration. This study evaluates specific leadership characteristics and their relationship to gender stereotyping. It also examines perceptions that individuals have on leadership based off because athletic administration is specifically a male dominated domain there appears to be discrimination against women inducing a gender gap, and stunting their advancement into top level managerial positions
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
- Appleby Bonny
- Appleby Rowan
- Archer Denise
- Archer Denise
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- Archer Simon
- Arnott Seonaid
- Arsanious Nasr
- Ashcroft Jan
- Ashworth Sue
- Ashworth Sue
- Askew Sarah
- Aslam Natasha
- Atkinson Jane
- Atkinson Lorraine
- Attlee Julie
- Auladin Raidah
- Austin (nee Glover) Gemma
- Austin Mandy
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- Avis Joanne
- Aya Viviana
- Azirar Hanna
- Bachand Francois
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- Bloomfield David
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- Brady Joanne
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- Branagan Jenny
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- Braun Michael W
- Brawley Chris
- Breakspear Sally
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- Chakraborti Prabir
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- Challipalli Amarnath
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- Chambers Carla
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- Charnley Natalie
- Chatelain AnneMarie
- Chatfield Jenny
- Chauhan Zainab
- Chedham Alison
- Chennattukungu Indukala
- Cherepak Kathy
- Chetiyawardana Samantha
- Chetiyawardana Samantha
- Chettle Judith
- Cheung Arthur
- Cheung Patrick CF
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- Chilcott Helen
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- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
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- Churn Mark
- Churn Mark
- Clancy Joanna
- Clapp Felicity
- Clark Alison
- Clark Diane
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- Clarke Maria
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- Conway Rachel
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- Danaswamy Patricia
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- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
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- Deenihan Emma
- Degendorfer Sarah
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- Dodds David
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- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
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- Dubey Arbind
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- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
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- Geraghty Kerry
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- Gibbins Jackie
- Gibbins Kate
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- Gilby Lisa
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- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
- Glen Hilary
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- Glick Daniel
- Goel Roshni
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- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldstein Cindy
- Goldsworthy Simon
- Gollapothu Srilakshmi
- Gomez JoseLuis
- Gomez-Marcos Raquel
- Gonzalez Celia
- Gooch Carol
- Goodhind Frances
- Goodsell Josie
- Goodsell Josie
- Goodwin Emma
- Gopaul Darindra
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- Gough Jessica
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- Goulding James
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- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
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- Guerrero-Urbano Teresa
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- Irwin P
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- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
- Jeffrey David
- Jelski Joseph
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- Jewers Karen
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- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
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- Kavanagh Roisin
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- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
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- Keith Sarah
- Kelkar Anand
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- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
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- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
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- Ammeter Barb
- Amoaten Thomas
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- Anderson Beverley
- Anderson Chris
- Anderson Jim
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- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
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- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
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- Heckford Louise
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- Hefferon Billy
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- Keng-Koh Pek
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- Keni Manjusha
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- King Amy
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- Lang Monika
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- Laniado M
- Lao Bernadeth
- Larkins Rachel
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- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
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- Malone Shawn
- Malone Shawn C
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- Morgan Scott
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- Morris Stephen L
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- Nabid Abdenour
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- Ngumo Alice
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- Nicholson Alastair
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- Oliverio Carmela
- Ong Aldrich D
- Ong Aldrich Dixon
- Oni Titilayo
- Onoge Ekugbe
- Oommen Nikhil
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- Page Nancy
- Pai Howard H
- Paisey Sangeeta
- Palmer Debbie
- Palmer Sarah
- Pamphlett Ian
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- Parker Chris
- Parker Chris C
- Parker Shelley
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- Parliament Matthew B
- Parmar Mahesh K B
- Parmar Max
- Parr Stephen
- Partington Lillian
- Partridge Kerena
- Parulekar Wendy
- Parulekar Wendy R
- Paschalis Alec
- Pascoe Caitlin
- Pascoe Sarah
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- Patel Anup
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- Perkins Lauren
- Perry Emily
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- Perry Heather
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- Perry Matthew
- Persad Raj
- Persad Rajendra A
- Pervez Nadeem
- Peterkin Zhane
- Peters John
- Petersen Peter M
- Peterson Jane
- Petroff Avi
- Petrovska Aleksandra
- Petsa Maria
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- Phillips Ann
- Philp Timothy
- Phipps Charlotte
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- Pigott Katherine
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- Pineda Sandra
- Pinnell Erin
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- Plataniotis George
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- Pugh Cheryl
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- Purandare Laura
- Purcell Keith
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- Rauchenberger Mary
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- Rawlings Julie
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- Redshaw Catherine
- Redshaw Catherine
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- Rees Andrew
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- Rendall Alice
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- Rezkallah Sarah
- Rezkallah Sarah
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- Ribeiro Helena
- Ribers Kristine
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- Rickert Lauren
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- Riley Karen
- Riley Karen
- Rimell Patricia
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- Riseborough Danielle
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- Rizzuto Stacey
- Roach Carol
- Roach Joanne
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- Robinson Angus
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- Robinson Nicola
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- Robson Paula
- Robson Peter
- Roca Mila
- Rodda Sree
- Rodda Sree
- Rodda Sree
- Rodda Sree
- Rodrigues George B
- Rodwell Sue
- Rogers Brian
- Rogers Eamonn
- Rogers Heather
- Rogers Jason
- Rogers Paul
- Rogers Thomas
- Rolfe Debbie
- Rooney Paula-Joanne
- Rooprai Bali
- Rose Jim
- Rose Tina
- Rosenfelder Nicola
- Rosoman Alison
- Ross Ashley
- Ross Kristy
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- Rotherham Carol
- Rousseau Pierre
- Rowe Edward
- Roxburgh Patricia
- Ruane Sarah
- Rudnicki Rayleen
- Ruiz Maria Jose Gaitan
- Russell Emily
- Russell Martin
- Russell Martin
- Russell Simon
- Russell Tamlyn
- Ruszala Elizabeth
- Rutledge Robert DH
- Rutter Charley-Anne
- Ryan Rachel
- Ryan-Smith Janet
- Ryan-Smith Janet
- Rønnengart Eva
- Saad Fred
- Saad Fred
- Sabate Kathryn
- Sabbagh Ahmad
- Sabbagh Robert
- Sabharwal Ami
- Sabharwal Ami
- Sabharwal Ami
- Sadare (Olaleye) Ibiyemi
- Sadare (Olaleye) Ibiyemi
- Sadozye Azmat
- Sahin Sarah
- Saldanha Helen
- Saleem Shamila
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- Samanci Ali
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- Sanchez Maria
- Sanders Kay
- Sandhu Sandeep
- Sangar Vijay
- Sankighatta Naveen
- Santos Priscilla
- Sargent Sister Tracey
- Sathya Jinka R
- Saunders Daniel
- Savage Sarah
- Sax Lori
- Saxe Charlotte
- Saxton Wendy
- Sayers Ian
- Sayers Ian
- Sayers Rachel
- Scarratt Lyndsay
- Schumacher Ann
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- Seath Ingrid
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- Sellars Elizabeth
- Sells Henry
- Seray-Wurie Fatimah
- Serpanchy Rosanne
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- Sewell Jane
- Sexton Tracy
- Shackley David
- Shaffer Richard
- Shaffer Richard
- Shahid Negin
- Shaji Preetha
- Shakespeare Devadasan
- Shantz Brenda S
- Sharif Shahid
- Sharma Atul
- Sharma Rajesh
- Sharman Emma
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- Shaw Alison
- Shearer Kirsty
- Sheehan Denise
- Sheehan Denise
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- Shires Heather
- Shiridzinomwa Constance
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- Sidek Norma
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- Sinfield Melanie
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- Sivananthan Gokulan
- Sivananthan Gokulan
- Sivoglo Virgil
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- Skelton Amy
- Skene Anna
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- Skwarski Michael
- Slack Jonathan
- Slessor Janet
- Slevin Kathryn
- Sloan Andrew
- Smale Daisy May
- Smallwood Sarah
- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
- Smedley (nee McCabe) Janine
- Smith Beccy
- Smith Carlie
- Smith Carolyn
- Smith Dan
- Smith Gill
- Smith Jackie
- Smith Lucy
- Smith Lucy
- Smith Lucy
- Smith Margaret
- Smith Matthew
- Smith Nick
- Smith Rachel
- Smith Rowena
- Smith Sandra
- Smith Sarah-Ellen
- Smith Sister Catherine
- Smith Susan
- Smith Suzanne
- So Alan I
- Sohanpal Sundip
- Sohanpal Sundip
- Somasiri Ashane
- Sorice Vittoria
- Souhami Luis
- Southgate Elizabeth
- Spalton Catherine
- Sparrow Geoffrey
- Spearman Mary
- Speed Lesley
- Spence Rachael
- Spencer Craig
- Spencer Hazel
- Spencer Patti
- Spencer Sue
- Spickett Helen
- Spillane Maria
- Spittle Ben
- Spoor Willemijn
- Springall Christine
- Spruce Debbie
- Squires Mandy
- Sreenivasan Thiagarajan
- Sreenivasan Thiagarajan
- Srihari Narayanan
- Srinivasan Rajaguru
- Srinivasan Rajaguru
- Srinivasan Vaiku
- Stacey Wendy
- Stafferton Ruth
- Staffurth John
- Staines Nikki
- Stammers Tracey
- Stancliffe May
- Stanley Laura
- Stapleton Stephanie
- Starling Ellen
- Steele Anita
- Steffensen Kirsten
- Stephens Rebekah
- Stephenson Anna
- Stephenson Anna
- Stevens Christiaan
- Stevens Nicole
- Stevenson Garry
- Stevenson Lesley
- Stevenson Robert
- Steventon Emily
- Stewart David
- Stewart Simon
- Stewart Simon
- Stewart Simon
- Stilling Sine
- Stockdale Andrew
- Stockdale Andrew
- Stockley Emma
- Stockport Jane
- Stoddart Jonathan
- Stone Helena
- Stone Matthew
- Stone Sarah
- Storer Julie
- Storrs Sarah
- Stott Mark
- Stott Matthew
- Stower Michael
- Stranex Stephen
- Stretch Alison
- Strider Paula
- Stringer (pr. Davis) Sally
- Strong-Sheldrake Sophia
- Stuart Robert
- Subramaniam Ramachandran
- Sullivan Frank
- Sumner Lesley
- Sundar Santhanam
- Sundar Santhanam
- Sundaram Subramanian Kanaga
- Sunny Manju
- Sutherland Donna
- Swann Michelle
- Sydes Matthew
- Sydes Matthew R
- Sylvestre Alma
- Symon Lesley
- Syndikus Isabel
- Szolin-Jones Jacob
- Szumacher Ewa
- Szymiczek Kinga
- Tahir Saad
- Tait Ellen
- Tan Matthew
- Tappenden Nancy
- Tapping Sister Hayley
- Tapping Sister Hayley
- Tasker Lorraine
- Tate Janine
- Taussky Daniel
- Tay Jessica
- Taylor Becky
- Taylor Beverley
- Taylor Carol
- Taylor Helen
- Taylor Henry
- Taylor Jacob
- Taylor Jacob
- Taylor Jennifer
- Taylor Jill
- Taylor Jo-Anne
- Taylor Kate
- Taylor Katy
- Taylor Katy
- Taylor Lisa
- Taylor Sister Melanie
- Teahan Seamus
- Teasdale Breanne
- Tedd Gemma
- Tee Elizabeth
- Teh Chiaw Woon
- Teh Jonathan
- Telfer Sheena
- Templeton Maureen
- tenHaaf Darlene
- Tennant Virginia
- Teo Mark
- TetreaultLaflamme Audrey
- Thackray Louis
- Thallury Sheeba
- Tharahan Nanthini
- Thevarajah Vaishaali
- Thibeault Andreanne
- Thim Stine
- Thind Manreet
- Thoi Anne-Maree
- Thoi Anne-Maree
- Thoi Anne-Maree
- Thomas Carys
- Thomas Carys
- Thomas Dianne
- Thomas Heather
- Thomas Helen
- Thomas Isobel
- Thomas Jacqueline
- Thomas Rachel
- Thomas Robert
- Thomas Sister Viv
- Thomasson Georgia
- Thominson Bronwen
- Thompson Catherine
- Thompson Catherine
- Thompson Chloe-Anne
- Thompson Emma
- Thompson Jane
- Thoms John
- Thomson Alastair H
- Thomson Sister Jane
- Thornton Lorraine
- Thorogood Lucy
- Tickle Vivienne
- Tickle Vivienne
- Tiessen Kyoko
- Tighe (nee Bussey) Rachel
- Tighe Helen
- Tighe Mary
- Tikoo Archana
- Timmings Katie
- Tindall Annie
- Tippins Anna
- Tipples Karen
- Todd Anne
- Todd Joanna
- Tolan Shaun
- Toledo Jesusa
- Tomlinson Annabel
- Tomlinson Eve
- Toms Julie
- Topalovich Aleksandra
- Topps Alice
- Torin Lehmann Anna
- Torres Cynthia
- Totten Grace
- Toussi H
- Townley Barbara
- Townley Luke
- Townsend-Thorn Debra
- Towse Jo
- Toy Elizabeth
- Trakalo Kathy
- Tran Anna
- Tran Anna
- Tranter Fiona
- Tranter Helen
- Tranter Helen
- Treasure Ann
- Tree Alison
- Tree Alison
- Treeby Jo
- Treherne Katy
- Tremlett Jean
- Trewsmith Neil
- Tribe Lisa
- Trigg-Hogarth Kate
- Trigonis Ioannis
- Trudel Diane
- Tsakirdis Thedoros
- Tsalic Medy
- Tsang David
- Tsang Lilian
- Tsawayo Tan
- Tse Karen
- Tseng Eric Chia Lin
- Tsuji Debbie
- Tuazon Juel
- Tuck Jonathan
- Tufail Aisha
- Turley Claudia
- Turley Claudia
- Turner Christy
- Turner Nikki
- Turner Sarah
- Turriff Lisa
- Tweedle James
- Tyldesley Scott
- Tyler Jayne
- Tyner Sharah
- Uherek Maja
- Upson Susan
- Urquhart Zoe
- Uscinska Barbara
- Usmani Nawaid
- Vallieres Isabelle
- Vamplew Luke
- Van As Nicholas
- Van der Voet Hans
- Van Someren Chloe
- Van-Koutrik Lynne
- Vandal Mohammad Tanvir
- Vandborg Maria
- Vandecandalaere Elaine
- Varley Gail
- Varro Robert
- Varughese Mohini
- Varughese Mohini
- Vasanthan Subramanian
- Vaughn Jamie
- Vavassis Peter
- Velec Erin
- Vengalil Salil
- Venkatesan Varagur M
- Venkitaraman Ramachandran
- Venkitaraman Ramachandran
- Vermette Tracy
- Vesprini Danny
- Vickery Kathryn
- Vigneault Eric
- Vijayakumar Vijitha
- Vilarino-Varela Maria
- Vincent Francois
- Vincent LindaSuzanne
- Vinod Cellins
- Virgo Azarel
- Vowell Emma
- Vu Thi
- Wade Lynne
- Wade Rob
- Wadsworth Oliver
- Wakefield Shauna
- Wakelen Paula
- Waldron Eleanor
- Walker Beth
- Walker Caroline
- Walker Georgina
- Walker Georgina
- Walker Heather
- Walker Jayashree
- Walker Julia
- Walker Karen
- Walker Lori
- Walker Suzanne
- Wall Elaine
- Wallace Jan
- Wallace Kris
- Wallbutton Rebecca
- Walmsley Catherine
- Walsh Donna
- Walton Jenny
- Walton Sharon
- Ward Angela
- Ward Colin
- Warde Padraig
- Waring Lynsey
- Waring Lynsey
- Wassall Rebecca
- Watkinson Catrin
- Watson Melanie R
- Watson Michaella
- Watson-Jones Phillip
- Watts Angela
- Watts Erica
- Weaver Andrew
- Weaver Emma
- Webb Andrew
- Webb Claire
- Webb Kerrie
- Webb Paula
- Websdale Cheryl
- Webster Christine
- Wei Joyce
- Weir JoAnn
- Wellman Sandie
- Wells Paula
- Wells Paula
- Wells Paula
- Wells Tom
- Welsh Liam
- Welsh Linda
- Westley Rosalyne
- Weston Alison
- Weston Philip
- Westrop Anna
- Westrop Anna
- Westrop Anna
- Wheatley Duncan
- Wheeler Lucie
- Wheelwright Roger
- Whelan Kate
- Whillis David
- Whinn Samantha
- Whitcher Alison
- White Ann
- White Holly
- White Joanna
- Whitehouse James
- Whitehouse James
- Whiteway Chrystal
- Whittle Stacy
- Whotton Nikita
- Wiggins Sarah
- Wightman John
- Wignall Suzy
- Wild Karen
- Wilke Derek
- Wilkie Karen
- Wilkins Marie
- Wilkinson Nicola
- Williams (Née Allen) Sister Tania
- Williams Amanda
- Williams Bethan
- Williams Candra
- Williams Jo
- Williams Joanne
- Williams Rachel
- Williams Rachel
- Williams-Yesson Barbara
- Williamson Elizabeth
- Williamson Nicola
- Willing Stephanie
- Wilson David
- Wilson Jim
- Wilson Jo
- Wilson Mark
- Wilson Paula
- Wilson Paula
- Wilson Russ
- Winn Carol
- Winter Sister Helen
- Wise Marcus
- Wise Marcus
- Wise Marcus
- Wiss Elliott
- Wollaston Julie
- Woloshyn Rose
- Wong Jason W T
- Wood Allison
- Wood Catherine
- Wood Cathryn
- Wood Marian
- Wood Pauline
- Wood Pauline
- Wood Sister Kim
- Wood Sister Kim
- Wood Sister Kim
- Woodhouse Iain
- Woods Catherine
- Woods Jane
- Woods Martin
- Woodward Cathryn
- Woodward Elizabeth
- Woolf David
- Woolf David
- Workman Bridget
- Worlding Jane
- Worlding Jane
- Worsley Lucy
- Worthington Hannah
- Wright Ann
- Wright Natalie
- Wright Seonaid
- Wrigley Martha
- Wronski Sue
- Wu Helen
- Wu Min
- Wyatt Clare
- Wylie James
- Wylie James
- Wylie James
- Wynn Hazel
- Wynn Hazel
- Yanchuk Janet
- Yarrow Sue
- Yassa Michael
- yates Victoria
- Yee Don
- Yeo Tanya
- Yoon Frederick
- Youd Sister Jill
- Young Anita
- Young Bobbie
- Young Douglas
- Young Sally
- Youngs Nora
- Yu Jason
- Yunace Lorrie
- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Stakeholder’s Perceptions of Needs, Abilities, & Quality of Life of Individuals with Severe & Persistent Mental Illness
- Publication venue
- NSUWorks
- Publication date
- 09/12/2018
- Field of study
Introduction: Approximately 1 in 5 adults (44.7 million individuals) were living with any kind of mental illness in the United States in 2016 (SAMHSA, 2016), but only 19.2 million of those individuals received mental health treatment during that period. Of those, 10.4 million adults (4.2 % of the general adult population), were estimated to have a serious and persistent mental illness (SPMI), but only 6.7 million of those individuals (64%) received mental health treatment in that same year (SAMHSA, 2016). In Florida, the prevalence of mental illness is estimated to be 660,000 (H.R. 8029, 2018). Yet, in terms of services for individuals with mental illness, and compared to other states, Florida’s ranking slid from 49th to 50th place in the past two years with a per capita expenditure of $39.55. SPMI affects individuals’ ability to function and to participate in valued roles and occupations, but recovery is attainable with appropriate interventions and services. This study aimed to understand factors that facilitate and those that hinder the recovery process through the perceptions of individuals with SMPI and of staff members providing services to them.
Methodology: This was a retrospective study of qualitative data collected through individual and focus group interviews by two research teams between 2016 and 2017. A clubhouse model drop-in center and residential facilities of a mental health center in central Florida provided the sampling frame. Sample size: There were 44 participants in the final sample (31 clients, 13 staff).
Results: Results reflected findings from the literature, indicating the personal nature of recovery, the importance of occupation (doing), identity (being), and kinship (belonging) in recovery, and how these have been impacted by cuts in funding and resources
Investigating the Algodones Dune Field of Southern California II : Using Geospatial Techniques
- Author
- Publication venue
- Publication date
- 01/05/2019
- Field of study
Color poster with text, images, and photographsThe Eastern Algodones Dunes, located in the Sonoran Desert, Imperial county, Southern California, stretch 72 kilometers and are 9.7 kilometers in width. The dunes were hypothesized to be a result of sediment blown from ancient Lake Cahuilla and are characterized by distinct regions: Glamis Beach, Gordon's Well, Buttercup, Midway, and Patton's Valley. The purpose of the research was to create a digital elevation model (DEM) of the sand starved dune complex by collecting aerial imagery using a DJI Phantom-4PG UAV. To improve overlap and tie points, the aerial imagery has a 75% front lap and a 65% side lap. The flight was flown at 50 meters above ground level and took 20 swaths overhead. To enhance the accuracy of the DEM, ten ground control points (GCPs) were collected using a REACH RS+ RTK GNSS receiver. In addition, a topographic survey was conducted using a TopCon laser leveler to more accurately geometrically correct the collected ground penetrating radar transects.University of Wisconsin--Eau Claire Office of Research and Sponsored Program
Shattering the concrete ceiling: exploring the moderating effects of mass media messages as it relates to the perceived self-efficacy of African-American women
- Author
- Publication venue
- Publication date
- Field of study
Past research has shown that there are few positive ethnically diverse role models in American society (Hackett & Betz, 1981). African-American women have identified the lack of racially identical role models as a significant barrier to attaining leadership positions within Corporate America. A cross-sectional survey was administered to explore how mass media images depicting counter-stereotypical images of African-American role models affect the self-efficacy beliefs of African-American women (195 respondents, 51%). The researcher also examined the participant’s ability to cope with stress and their reported level of career aspirations as predictors of their level of identification with the potential role model. The results indicated that African-American women have lower levels of both self-efficacy and career aspirations than women of other races (187 respondents, 49%). The results also indicated that the participant’s ability to cope with stress and level of career aspirations predicated their level of identification. Furthermore, the study found that a potential role models race significantly influenced the participants level of identification. This research will foster social change by identifying an effective approach to combating historical stereotypes that lower the self-efficacy of African-American women. Increasing the self-efficacy of African-American women could advance opportunities for minority women’s leadership and reduce the leadership gap in Corporate America. (Published By University of Alabama Libraries
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
- Bernard Grunstra
- Beth Safirstein
- Bethanie Wilkinson
- Beverly E. Sha
- Beverly Ewing
- Bindu Balani
- Blanca Gomez
- Bo Shopsin
- Boerries Brandenburg
- Brandie Taylor
- Brandon J. Essink
- Brandy Ball
- Breanz Watkins
- Brenda Dorcely
- Brendan Levy
- Brett Gray
- Brett Leav
- Brian D.W. Chow
- Brit Sovic
- Brittany Feijoo
- Brittany Stewart
- Bruce C. Gebhardt
- Bruce G. Rankin
- Bruce McClenathan
- Bruno Valenti
- Bryan Gordon
- C. Mary Healy
- Caitlin J. Guiney
- Caitlin Moran
- Candace Smith
- Candice Montros
- Carina A. Rodriguez
- Carl Fichtenbaum
- Carl P. Griffin
- Carlos A. Fierro
- Carlos del Rio
- Carlos Lopez
- Carlos Malvestutto
- Carmel B. Dyer
- Carmen A. Paez
- Carmen Amador
- Carmen D. Zorrilla
- Carmen Medina
- Carol Ann Linebarger
- Carol Kauffman
- Carol L. Mitchell
- Carolene Stephenson
- Caroline Greene
- Carolyn Scatamacchia
- Carolyn Tran
- Carrie Johnston
- Carrie Sopher
- Catherine A. Bunce
- Catherine Mary Healy
- Catherine Q. Gular
- Cathy Laflan
- Cecilia McKeown-Bragas
- Celia Gonzalez
- Celia Maxwell
- Charles Harper
- Charles M. Fogarty
- Charlotte-Paige Rolle
- Charnell Cromer
- Chelsea Miles
- Chelsie Nutsch
- Chelsie Nutsch
- Chen S. Tan
- Chenchen Yu
- Cheryl Nuss
- Cheryl Young
- Chimeremma Nnadi
- Chinar Desai
- Christian Tomaszewski
- Christina A. Rostad
- Christina Bacher
- Christina Kennelly
- Christine Akamine
- Christine B. Turley
- Christine Hull
- Christine Wilson
- Christopher Carpenter
- Christopher Dedon
- Christopher Galloway
- Christopher Matich
- Christy Schmeck
- Christy Sweet
- Clarence B. Creech II
- Clarisse Baudelaire
- Claudia De La Matta Rodriguez
- Claudia Espinosa
- Claudio Nuñez Lagos
- Clint C. Guillory
- Clint Wilson
- Codi M. Anthony
- Colleen F. Kelley
- Colleen Jacobsen
- Connie Moya
- Cora Sonnier
- Corey G. Anderson
- Corey M. Chen
- Cornell Calinescu
- Corrina Pavetto
- Cortney Burch
- Cory J. Huffine
- Craig Dietz
- Cristina Cicogna
- Crystal Rowell
- Cynthia Becher Strout
- Cynthia Brown
- Cynthia Bueno
- Cynthia L. Gay
- Cynthia L. Monaco
- Cynthia Montano-Pereira
- Cyrus Hoseyni
- Dakotah C. Lane
- Dalia Tovar
- Daniel Duncanson
- Daniel Hoft
- Daniel Kaul
- Daniel S. Graciaa
- Daniel T. Lawler
- Daniela Pineda Méndez
- Danielle Raley
- Danny Sugimoto
- Danyel Johnson
- Darlene Bartilucci
- David B. Musante
- David Beckmann
- David Browder
- David Dellaero
- David Fitz-Patrick
- David Halpert
- David I. Bernstein
- David J. Diemert
- David J. Ensz
- David Kline
- David L. Fried
- David Metzger
- David Pampe
- David Pitrak
- David R. Andes
- David Rosenberg
- David Tatelbaum
- David Wohl
- Dawn Furey
- Dawn Robison
- Dean Follmann
- Dean M. Boswell
- Deanna Cooper
- Debora Dunbar
- Deborah A. Theodore
- Deborah Murray
- Debra B. Schroeck
- Delia Bullock
- Denis Tarakjian
- Denise Casey
- Denise Roadman
- Denise Sample
- Denisse Alejandra González Estrada
- Derek Lewis
- Derek M. Smith
- Destiny S. Heinzig-Cartwright
- Diana Badillo
- Diana F. Florescu
- Diana Vegas
- Dianca Sierra
- Diane H. Johnson
- Dilek Ince
- Dima Dandachi
- Dirk Heerwegh
- Dolores Rijos
- Donald M. Brandon
- Donald Quinn
- Donna Percy
- Doris Franco-Vitteri
- Douglas S. Denham
- E. Javier Pretell Alva
- Edgar Garcia
- Edith Swann
- Eduardo Gabriel Vázquez Saldaña
- Edward C. Jones-López
- Edward E. Walsh
- Edward Ellerbeck
- Edward M. Tavel Jr.
- Elham Ghadishah
- Elie Gharib
- Elisa Swieboda
- Elissa Malkin
- Elizabeth Barranco-Santana
- Elizabeth Bennett
- Elizabeth Bruce
- Elizabeth Danford
- Elizabeth Duke
- Elizabeth E. Robison
- Elizabeth Everette
- Elizabeth Formentini
- Elizabeth Hammershaimb
- Elizabeth Parker
- Elizabeth Secord
- Ellie Carmody
- Elliot DeHaan
- Elwaleed Elnagar
- Emily Degan
- Emily Oppenheim
- Emma Bainbridge
- Emmanuel B. Walter
- Eneyda Giuvanela Llerena Zegarra
- Enrique Ocaña
- Eric A. Meyerowitz
- Eric Bravo
- Eric McGrath
- Eric Miller
- Erica Herc
- Erica Johnson
- Erica Osmundsen
- Erica Sanchez
- Erika A. Cutz
- Erika Mendoza
- Erin A. Goecker
- Erin Cooksey
- Erin Coston
- Ernesto Delgado
- Esther L. Harmon
- Esther S. Huffine
- Evan C. Ewers
- Evan J. Anderson
- Evelyn Hall
- Evelyn Lomasney
- Evelyn Quevedo
- Fan Yang
- Farah Irani
- Farhan Siddiqui
- Fernanda Morales
- Fernando L. Merino
- Filip Dubovsky
- Flora Castellino
- Florence Momplaisir
- Florida Aristy
- Frances Downing
- Frank James
- Frank S. Eder
- Frank Struyf
- Fred E. Newton
- Frederick Raiser III
- Fredric Santiago
- Gail Broder
- Gary Albert
- Gary Headden
- Gary Horwith
- Gary Luckasen
- Gary Simon
- Gayle D. Hennekes
- Genevieve Beninati
- Genevieve Iwuala
- George H. Bauer Jr.
- George H. Freeman
- Georgette Ebuh
- Georgettea Geuss
- Gerald Kelty
- Germán Áñez
- Getahun Abate
- Gina Rivero
- Glenda E. Gray
- Glenn Wortman
- Gowdhami Mohan
- Grant Ellsworth
- Grant Geiger
- Greg Hachigian
- Greg Wilson
- Gregg H. Lucksinger
- Gregory C. Utz
- Gregory Holt
- Gregory J. Feldman
- Gregory M. Glenn
- Gregory M. Gottschlich
- Griet Van Roey
- Guillermo Miguel Ruiz-Palacios
- Gysella Muniz
- Hala Webster
- Hana M. El Sahly
- Hanh Chu
- Hanh Chu
- Hannah Catan
- Hannah Harrington
- Hannah Nevarez
- Haoua Dunbar
- Hayes Williams
- Heather Rattenbury-Shaw
- Henry Peralta
- Hilario Alvarado
- Hillary Dunlevy
- Holli Hamilton
- Holly E. Janes
- Hong V. Tieu
- Horacio Marafioti
- Howard I. Schwartz
- Howard Schwartz
- Hussain Malbari
- Huub G. Gelderblom
- Hyman Scott
- Ian De Proost
- Ian Frank
- Ian Hirsch
- Iksung Cho
- Ilse Van Dromme
- Insiya Valika
- Irene Graham
- Irene McKnight
- Iris García
- Isaac Thomsen
- Isabel Pereira
- Issac Pena-Renteria
- Jack Stapleton
- Jacob Coleman
- Jacqueline Miller
- Jacqueline Muenzner
- Jaleh Ostovar
- Jaleh Ostovar
- Jalima Quintero
- James Andersen
- James Fry
- James G. Kublin
- James H. Conway
- James Longe
- James Lovell
- James N. Goldenberg
- James Peacock
- James Ramsey
- James T. Peterson
- James W. Hurst
- James Walker
- James Zhou
- Jamie Ackerman
- Jamshid Saleh
- Jan Patterson
- Janet Garvey
- Janet Hill
- Janet Mendez
- Janet Otto
- Janeth Pacheco-Flores
- Janice Suyehira
- Janine Maenza
- Jarek Juraszek
- Jason F. Okulicz
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- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
- Vicki E. Miller
- Vickie Leathers
- Victoria Andriulis
- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Recommended from our members
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
- Baden Lindsey R.
- Badillo Diana
- Bainbridge Emma
- Baka Michele
- Baker Sherrie
- Balani Bindu
- Ball Brandy
- Bances Karla Beatriz Tafur
- Baron Mira
- Barranco-Santana Elizabeth
- Bartilucci Darlene
- Bashour Jennifer
- Batteiger Teresa A.
- Baudelaire Clarisse
- Bazan Jose A.
- Becerra Maria G.
- Becker Teresa
- Beckmann David
- Bedimo Roger J.
- Belhorn Linda R.
- Benavides Alfredo Gilberto Guerreros
- Beninati Genevieve
- Benitez Jorge A.
- Bennett Annette R.
- Bennett Elizabeth
- Beresnev Tatiana
- Berman Megan
- Bermudez Maria I.
- Bernard Marcia
- Bernstein David I.
- Berry Andrea
- Berry Jennifer
- Berthaud Vladimir
- Bialobok Kristin
- Billings Joanne L.
- Bittner Zachary
- Blevins Jeanne
- Blumenthal Jill
- Boas Rebecca
- Bocchini Joseph
- Bold Tyler D.
- Bondell Alison
- Bondy Paul
- Borger Judith
- Borgetti Scott
- Boscia Joseph
- Boswell Dean M.
- Bourgeois Tana
- Bowers Maggie
- Bradley Paul S.
- Brady Judith
- Brakema Riemke
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- Bravo Eric
- Briskin Toby
- Broder Gail
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- Callis Jim
- Camacho-Gonzalez Andres
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- Carmody Ellie
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- Carvajal Marianela
- Casey Denise
- Caso Jorge
- Castellino Flora
- Castellon Marvin
- Castro Mario
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- Cavert Winston
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- Chadwick Mesha M.
- Chamberlain Amy
- Chan Austin
- Chang Jennifer
- Chebib Mouna G.
- Chen Corey M.
- Cheng Margaret
- Cho Iksung
- Choquette Karin
- Chouteau R. Michelle
- Chow Brian D.W.
- Choza Laura Julia Camacho
- Chrisley Lisa
- Christensen Shane G.
- Chu Hanh
- Chu Laurence
- Chughtai Waseem
- Chung Michael
- Ciambruschini Annie
- Cicogna Cristina
- Clarence B. Creech I I
- Clark Alexander
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- Clement Andrea
- Clement Lauren
- Clemons Steve
- Cohen Lisa
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- Edupuganti Srilatha
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- Zorrilla Carmen D.
- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health