CXCR4-targeted and MMP-responsive iron oxide nanoparticles for enhanced magnetic resonance imaging

MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity. In this study, two sets of iron oxide nanoparticles (IONPs) were synthesized that were designed to selectively undergo copper-free click conjugation upon sensing of matrix metalloproteinase (MMP) enzymes, thereby leading to a self-assembled superparamagnetic nanocluster network with T2 signal enhancement properties. For this purpose, IONPs with bioorthogonal azide and alkyne surfaces masked by polyethylene glycol (PEG) layers tethered to CXCR4-targeted peptide ligands were synthesized and characterized. The IONPs were tested in vitro and T2 signal enhancements of around 160 % were measured when the IONPs were incubated with cells expressing MMP2/9 and CXCR4. Simultaneous systemic administration of the bioorthogonal IONPs in tumor-bearing mice demonstrated the signal-enhancing ability of these ‘smart’ self-assembling nanomaterials

Galactic X-ray binary jets

With their relatively fast variability time-scales, Galactic X-ray binaries provide an excellent laboratory to explore the physics of accretion and related phenomena, most notably outflows, over different regimes. After comparing the phenomenology of jets in black hole X-ray binary systems to that of neutron stars, here I discuss the role of the jet at very low Eddington ratios, and present preliminary results obtained by fitting the broadband spectral energy distribution of a quiescent black hole binary with a `maximally jet-dominated' model.Comment: Refereed version, accepted for publication in Astrophysics & Space Scienc

Limits on the quiescent radio emission from the black hole binaries GRO J1655-40 and XTE J1550-564

We present the results of radio observations of the black hole binaries GRO J1655-40 and XTE J1550-564 in quiescence, with the upgraded Australia Telescope Compact Array. Neither system was detected. Radio flux density upper limits (3 sigma) of 26 micro Jy (at 5.5 GHz), 47 micro Jy (at 9 GHz) for GRO J1655-40, and 1.4 mJy (at 1.75 GHz), 27 micro Jy (at 5.5 GHz), 47 micro Jy (at 9 GHz) for XTE J1550-564 were measured. In conjunction with quasi-simultaneous Chandra X-ray observations (in the case of GRO J1655-40) and Faulkes Telescope optical observations (XTE J1550-564) we find that these systems provide the first evidence of relatively `radio quiet' black hole binaries at low luminosities; indicating that the scatter observed in the hard state X-ray:radio correlation at higher luminosities may also extend towards quiescent levels.Comment: Accepted for publication in MNRA

Compact massive objects in Virgo galaxies: the black hole population

We investigate the distribution of massive black holes (MBHs) in the Virgo cluster. Observations suggest that AGN activity is widespread in massive galaxies (M>1e10 solar masses), while at lower galaxy masses star clusters are more abundant, which might imply a limited presence of central black holes in these galaxy-mass regimes. We explore if this possible threshold in MBH hosting, is linked to nature, nurture, or a mixture of both. The nature scenario arises naturally in hierarchical cosmologies, as MBH formation mechanisms typically are efficient in biased systems, which would later evolve into massive galaxies. Nurture, in the guise of MBH ejections following MBH mergers, provides an additional mechanism that is more effective for low mass, satellite galaxies. The combination of inefficient formation, and lower retention of MBHs, leads to the natural explanation of the distribution of compact massive ob jects in Virgo galaxies. If MBHs arrive to the correlation with the host mass and velocity dispersion during merger-triggered accretion episodes, sustained tidal stripping of the host galaxies creates a population of MBHs which lie above the expected scaling between the holes and their host mass, suggesting a possible environmental dependence.Comment: MNRAS letter

Phase transitions in social sciences: two-populations mean field theory

A new mean field statistical mechanics model of two interacting groups of spins is introduced and the phase transition studied in terms of their relative size. A jump of the average magnetization is found for large values of the mutual interaction when the relative percentage of the two populations crosses a critical threshold. It is shown how the critical percentage depends on internal interactions and on the initial magnetizations. The model is interpreted as a prototype of resident-immigrant cultural interaction and conclusions from the social sciences perspectives are drawn