113 research outputs found
Image Co-localization by Mimicking a Good Detector's Confidence Score Distribution
Given a set of images containing objects from the same category, the task of
image co-localization is to identify and localize each instance. This paper
shows that this problem can be solved by a simple but intriguing idea, that is,
a common object detector can be learnt by making its detection confidence
scores distributed like those of a strongly supervised detector. More
specifically, we observe that given a set of object proposals extracted from an
image that contains the object of interest, an accurate strongly supervised
object detector should give high scores to only a small minority of proposals,
and low scores to most of them. Thus, we devise an entropy-based objective
function to enforce the above property when learning the common object
detector. Once the detector is learnt, we resort to a segmentation approach to
refine the localization. We show that despite its simplicity, our approach
outperforms state-of-the-art methods.Comment: Accepted to Proc. European Conf. Computer Vision 201
Learning Behavioural Context
The original publication is available at www.springerlink.co
N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation
© 2018 National Academy of Sciences. All Rights Reserved. The huntingtin N17 domain is a modulator of mutant huntingtin toxicity and is hypophosphorylated in Huntington’s disease (HD). We conducted high-content analysis to find compounds that could restore N17 phosphorylation. One lead compound from this screen was N6-furfuryladenine (N6FFA). N6FFA was protective in HD model neurons, and N6FFA treatment of an HD mouse model corrects HD phenotypes and eliminates cortical mutant huntingtin inclusions. We show that N6FFA restores N17 phosphorylation levels by being salvaged to a triphosphate form by adenine phosphoribosyltransferase (APRT) and used as a phosphate donor by casein kinase 2 (CK2). N6FFA is a naturally occurring product of oxidative DNA damage. Phosphorylated huntingtin functionally redistributes and colocalizes with CK2, APRT, and N6FFA DNA ad-ducts at sites of induced DNA damage. We present a model in which this natural product compound is salvaged to provide a triphosphate substrate to signal huntingtin phosphorylation via CK2 during low-ATP stress under conditions of DNA damage, with protective effects in HD model systems
Patch-level spatial layout for classification and weakly supervised localization
International audienceWe propose a discriminative patch-level spatial layout model suitable for training with weak supervision. We start from a block-sparse model of patch appearance based on the normalized Fisher vector representation. The appearance model is responsible for i) selecting a discriminative subset of visual words, and ii) identifying distinctive patches assigned to the selected subset. These patches are further filtered by a sparse spatial model operating on a novel representation of pairwise patch layout. We have evaluated the proposed pipeline in image classification and weakly supervised localization experiments on a public traffic sign dataset. The results show significant advantage of the proposed spatial model over state of the art appearance models
Concepções de avaliação de desempenho em um currĂculo orientado por competĂŞncia
O objetivo deste estudo foi identificar concepções de avaliação dos docentes no ExercĂcio de Avaliação da Prática Profissional (EAPP). Foram analisados 155 instrumentos de avaliação preenchidos pelos docentes e filmados os EAPP de quatro estudantes de primeira e terceira sĂ©ries. Para análise dos dados, utilizou-se o MĂ©todo de Interpretação dos Sentidos. As concepções de avaliação expressas pelos docentes aproximaram-se da abordagem de competĂŞncia dialĂłgica, valorizando tanto produto quanto processo, o que contribui para diminuir os efeitos negativos da avaliação. Mudanças nas concepções de avaliação requerem um processo de construção institucional, com participação ativa da comunidade acadĂŞmica, considerando as concepções existentes e buscando produzir consensos
Author Correction: Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)
Correction to: npj Parkinson’s Disease, published online 27 June 2023 In this article the Global Parkinson’s Genetics Program (GP2) members names and affiliations were missing in the main author list of the Original article which are listed in the below
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