5,951 research outputs found

    Restricted dog leucocyte antigen (DLA) class II haplotypes and genotypes in Beagles

    Get PDF
    AbstractBeagles are commonly used in vaccine trials as part of the regulatory approval process. Genetic restriction within this breed and the impact this might have on vaccine responses are rarely considered. This study was designed to characterise diversity of dog leucocyte antigen (DLA) class II genes in a breeding colony of laboratory Beagles, whose offspring are used in vaccine studies. DLA haplotypes were determined by PCR and sequence-based typing from genomic DNA extracted from blood. Breeding colony Beagles had significantly different DLA haplotype frequencies in comparison with pet Beagles and both groups showed limited DLA diversity. Restricted DLA class II genetic variability within Beagles might result in selective antigen presentation and vaccine responses that are not necessarily representative of those seen in other dog breeds

    Reversible enhancement of the magnetism of ultrathin Co films by H adsorption

    Full text link
    By means of ab initio calculations, we have investigated the effect of H adsorption in the structural, electronic and magnetic properties of ultrathin Co films on Ru(0001). Our calculations predict that H occupies hollow sites preserving the two-dimensional 3-fold symmetry. The formation of a complete H overlayer leads to a very stable surface with strong H-Co bonds. H tends to suppress surface features, in particular, the enhancement of the magnetic moments of the bare film. The H-induced effects are mostly confined to the Co atoms bonded to H, independent of the H coverage or of the thickness and the structure of the Co film. However, for partial H coverages a significant increase occurs in the magnetic moment for the surface Co atoms not bonded to H, leading to a net enhancement of surface magnetism.Comment: 6 pages, 4 figures, 3 table

    A minor-merger origin for inner disks and rings in early-type galaxies

    Get PDF
    Nuclear disks and rings are frequent galaxy substructures, for a wide range of morphological types (from S0 to Sc). We have investigated the possible minor-merger origin of inner disks and rings in spiral galaxies through collisionless N-body simulations. The models confirm that minor mergers can drive the formation of thin, kinematically-cold structures in the center of galaxies out of satellite material, without requiring the previous formation of a bar. Satellite core particles tend to be deposited in circular orbits in the central potential, due to the strong circularization experienced by the satellite orbit through dynamical friction. The material of the satellite core reaches the remnant center if satellites are dense or massive, building up a thin inner disk; whereas it is fully disrupted before reaching the center in the case of low-mass satellites, creating an inner ring instead.Comment: 2 pages, 2 figures, Proceedings of the conference "Hunting for the Dark: The Hidden Side of Galaxy Formation", held in Malta, 19-23 Oct. 2009, ed. V. Debattista and C. C. Popescu, AIP Conf. Ser., in pres

    Surface roughness and thermal conductivity of semiconductor nanowires: going below the Casimir limit

    Full text link
    By explicitly considering surface roughness at the atomic level, we quantitatively show that the thermal conductivity of Si nanowires can be lower than Casimir's classical limit. However, this violation only occurs for deep surface degradation. For shallow surface roughness, the Casimir formula is shown to yield a good approximation to the phonon mean free paths and conductivity, even for nanowire diameters as thin as 2.22 nm. Our exact treatment of roughness scattering is in stark contrast with a previously proposed perturbative approach, which is found to overpredict scattering rates by an order of magnitude. The obtained results suggest that a complete theoretical understanding of some previously published experimental results is still lacking.Comment: 11 pages, 4 figure

    Scaling of Local Slopes, Conservation Laws and Anomalous Roughening in Surface Growth

    Full text link
    We argue that symmetries and conservation laws greatly restrict the form of the terms entering the long wavelength description of growth models exhibiting anomalous roughening. This is exploited to show by dynamic renormalization group arguments that intrinsic anomalous roughening cannot occur in local growth models. However some conserved dynamics may display super-roughening if a given type of terms are present.Comment: To appear in Phys. Rev. Lett., 4 pages in RevTeX style, no fig
    corecore